The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity
Maurer, Mark F., Lewis, Katherine E., Kuijper, Joseph L., Ardourel, Dan, Gudgeon, Chelsea J., Chandrasekaran, Siddarth, Mudri, Sherri L., Kleist, Kayla N., Navas, Chris, Wolfson, Martin F., Rixon, Mark W., Swanson, Ryan, Dillon, Stacey R., Levin, Steven D., Kimbung, Yengo Raymond, Akutsu, Masato, Logan, Derek T., Walse, Björn, Swiderek, Kristine M., Peng, Stanford L.
Published in Nature communications (04.04.2022)
Published in Nature communications (04.04.2022)
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ATH-1105, a small-molecule positive modulator of the neurotrophic HGF system, is neuroprotective, preserves neuromotor function, and extends survival in preclinical models of ALS
Berthiaume, Andrée-Anne, Reda, Sherif M, Kleist, Kayla N, Setti, Sharay E, Wu, Wei, Johnston, Jewel L, Taylor, Robert W, Stein, Liana R, Moebius, Hans J, Church, Kevin J
Published in Frontiers in neuroscience (08.02.2024)
Published in Frontiers in neuroscience (08.02.2024)
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Development of Novel Small Molecules Targeting Neurotrophic HGF Signaling for the Treatment of Alzheimer’s, Parkinson’s, and ALS
Taylor, Robert W., Berthiaume, Andree-Anne, Kleist, Kayla N., Reda, Sherif M., Setti, Sharay E., Johnston, Jewel L., Wu, Wei, Church, Kevin J.
Published in Neurotherapeutics (01.07.2024)
Published in Neurotherapeutics (01.07.2024)
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ATH‐1105, a small molecule positive modulator of the HGF/MET system, is neuroprotective and attenuates TDP‐43 protein pathology in ALS and frontotemporal dementia‐relevant preclinical models
Johnston, Jewel L, Berthiaume, Andrée‐Anne, Reda, Sherif, Kleist, Kayla N., Setti, Sharay E., Wu, Wei, Church, Kevin J.
Published in Alzheimer's & dementia (01.12.2023)
Published in Alzheimer's & dementia (01.12.2023)
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Biomarker analyses from the phase 2, randomized, placebo‐controlled ACT‐AD and open‐label extension clinical trials of fosgonimeton in patients with mild‐to‐moderate Alzheimer’s disease
Moebius, Hans J., Ooi, Kai‐Bin C., Hale, Michael D., Setti, Sharay E., Kleist, Kayla N., Pan, Josh, Church, Kevin J., Sabbagh, Marwan
Published in Alzheimer's & dementia (01.12.2023)
Published in Alzheimer's & dementia (01.12.2023)
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Povetacicept, an Enhanced Dual APRIL/BAFF Antagonist That Modulates B Lymphocytes and Pathogenic Autoantibodies for the Treatment of Lupus and Other B Cell–Related Autoimmune Diseases
Evans, Lawrence S., Lewis, Katherine E., DeMonte, Daniel, Bhandari, Janhavi G., Garrett, Logan B., Kuijper, Joseph L., Ardourel, Daniel, Wolfson, Martin F., Debrot, Susan, Mudri, Sherri, Kleist, Kayla, Griffin, Luana L., Hebb, LuAnne, Sanderson, Russell J., Wang, NingXin, Seaberg, Michelle, Chunyk, Allison G., Yang, Jing, Hong, Youji, Maria, Zahra, Messenheimer, David J., Holland, Pamela M., Peng, Stanford L., Rixon, Mark W., Dillon, Stacey R.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.07.2023)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.07.2023)
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Abstract LB-085: ALPN-202 combines checkpoint inhibition with conditional T cell costimulation to overcome T cell suppression by M2c macrophages and improve the durability of engineered T cell anti-tumor responses
Maurer, Mark F., Chandrasekaran, Siddarth, Lewis, Katherine, Mudri, Sherri, Kleist, Kayla, Ahmed-Qadri, Fariha, Gudgeon, Chelsea, Levin, Steven D., Dillon, Stacey R., Swiderek, Kristine M., Peng, Stanford L.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Non‐Redundant Roles of T Cell Costimulation Pathways in Inflammatory Arthritis Revealed by Dual Blockade of ICOS and CD28 with Acazicolcept (ALPN‐101)
Dillon, Stacey R., Evans, Lawrence S., Lewis, Katherine E., Debrot, Susan, Blair, Tiffany C., Mudri, Sherri, Kleist, Kayla, Levin, Steven D., Bhandari, Janhavi G., Garrett, Logan, Wolfson, Martin F., Holland, Pamela M., Rixon, Mark W., Peng, Stanford L.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.08.2023)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.08.2023)
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Abstract 1740: Engineered variant domain fusion proteins provide checkpoint inhibition and tumor antigen dependent CD28 costimulation resulting in potent anti-tumor immunity
Levin, Steven D., Maurer, Mark F., Gudgeon, Chelsea, Chandrasekaran, Siddarth, Ardourel, Daniel, Demonte, Daniel, Kuijper, Joseph, Wolfson, Martin, Garrett, Logan, Kleist, Kayla N., Mudri, Sherri, Nguyen, Hieu, Seaberg, Michelle, Wang, Rachel, Yang, Jing, Lewis, Katherine E., Dillon, Stacey R., Rixon, Mark, Peng, Stanford L.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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