Enhanced proofreading governs CRISPR-Cas9 targeting accuracy
Chen, Janice S, Dagdas, Yavuz S, Kleinstiver, Benjamin P, Welch, Moira M, Sousa, Alexander A, Harrington, Lucas B, Sternberg, Samuel H, Joung, J Keith, Yildiz, Ahmet, Doudna, Jennifer A
Published in Nature (London) (19.10.2017)
Published in Nature (London) (19.10.2017)
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Journal Article
Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss
György, Bence, Nist-Lund, Carl, Pan, Bifeng, Asai, Yukako, Karavitaki, K Domenica, Kleinstiver, Benjamin P, Garcia, Sara P, Zaborowski, Mikołaj P, Solanes, Paola, Spataro, Sofia, Schneider, Bernard L, Joung, J Keith, Géléoc, Gwenaëlle S G, Holt, Jeffrey R, Corey, David P
Published in Nature medicine (01.07.2019)
Published in Nature medicine (01.07.2019)
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Journal Article
Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells
Kleinstiver, Benjamin P, Tsai, Shengdar Q, Prew, Michelle S, Nguyen, Nhu T, Welch, Moira M, Lopez, Jose M, McCaw, Zachary R, Aryee, Martin J, Joung, J Keith
Published in Nature biotechnology (01.08.2016)
Published in Nature biotechnology (01.08.2016)
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Journal Article
Astrocytic interleukin-3 programs microglia and limits Alzheimer's disease
McAlpine, Cameron S, Park, Joseph, Griciuc, Ana, Kim, Eunhee, Choi, Se Hoon, Iwamoto, Yoshiko, Kiss, Máté G, Christie, Kathleen A, Vinegoni, Claudio, Poller, Wolfram C, Mindur, John E, Chan, Christopher T, He, Shun, Janssen, Henrike, Wong, Lai Ping, Downey, Jeffrey, Singh, Sumnima, Anzai, Atsushi, Kahles, Florian, Jorfi, Mehdi, Feruglio, Paolo Fumene, Sadreyev, Ruslan I, Weissleder, Ralph, Kleinstiver, Benjamin P, Nahrendorf, Matthias, Tanzi, Rudolph E, Swirski, Filip K
Published in Nature (London) (29.07.2021)
Published in Nature (London) (29.07.2021)
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Journal Article
High levels of AAV vector integration into CRISPR-induced DNA breaks
Hanlon, Killian S, Kleinstiver, Benjamin P, Garcia, Sara P, Zaborowski, Mikołaj P, Volak, Adrienn, Spirig, Stefan E, Muller, Alissa, Sousa, Alexander A, Tsai, Shengdar Q, Bengtsson, Niclas E, Lööv, Camilla, Ingelsson, Martin, Chamberlain, Jeffrey S, Corey, David P, Aryee, Martin J, Joung, J Keith, Breakefield, Xandra O, Maguire, Casey A, György, Bence
Published in Nature communications (30.09.2019)
Published in Nature communications (30.09.2019)
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Journal Article
Multimodal CRISPR perturbations of GWAS loci associated with coronary artery disease in vascular endothelial cells
Wünnemann, Florian, Fotsing Tadjo, Thierry, Beaudoin, Mélissa, Lalonde, Simon, Lo, Ken Sin, Kleinstiver, Benjamin P, Lettre, Guillaume
Published in PLoS genetics (16.03.2023)
Published in PLoS genetics (16.03.2023)
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Journal Article
Discovery of widespread type I and type V CRISPR-Cas inhibitors
Marino, Nicole D, Zhang, Jenny Y, Borges, Adair L, Sousa, Alexander A, Leon, Lina M, Rauch, Benjamin J, Walton, Russell T, Berry, Joel D, Joung, J Keith, Kleinstiver, Benjamin P, Bondy-Denomy, Joseph
Published in Science (American Association for the Advancement of Science) (12.10.2018)
Published in Science (American Association for the Advancement of Science) (12.10.2018)
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Journal Article
Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing
Kleinstiver, Benjamin P, Sousa, Alexander A, Walton, Russell T, Tak, Y Esther, Hsu, Jonathan Y, Clement, Kendell, Welch, Moira M, Horng, Joy E, Malagon-Lopez, Jose, Scarfò, Irene, Maus, Marcela V, Pinello, Luca, Aryee, Martin J, Joung, J Keith
Published in Nature biotechnology (01.03.2019)
Published in Nature biotechnology (01.03.2019)
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Journal Article
Activities and specificities of CRISPR/Cas9 and Cas12a nucleases for targeted mutagenesis in maize
Lee, Keunsub, Zhang, Yingxiao, Kleinstiver, Benjamin P., Guo, Jimmy A., Aryee, Martin J., Miller, Jonah, Malzahn, Aimee, Zarecor, Scott, Lawrence‐Dill, Carolyn J., Joung, J. Keith, Qi, Yiping, Wang, Kan
Published in Plant biotechnology journal (01.02.2019)
Published in Plant biotechnology journal (01.02.2019)
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Journal Article
Optimization of AsCas12a for combinatorial genetic screens in human cells
DeWeirdt, Peter C, Sanson, Kendall R, Sangree, Annabel K, Hegde, Mudra, Hanna, Ruth E, Feeley, Marissa N, Griffith, Audrey L, Teng, Teng, Borys, Samantha M, Strand, Christine, Joung, J Keith, Kleinstiver, Benjamin P, Pan, Xuewen, Huang, Alan, Doench, John G
Published in Nature biotechnology (01.01.2021)
Published in Nature biotechnology (01.01.2021)
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Journal Article
Treatment of monogenic and digenic dominant genetic hearing loss by CRISPR-Cas9 ribonucleoprotein delivery in vivo
Tao, Yong, Lamas, Veronica, Du, Wan, Zhu, Wenliang, Li, Yiran, Whittaker, Madelynn N, Zuris, John A, Thompson, David B, Rameshbabu, Arun Prabhu, Shu, Yilai, Gao, Xue, Hu, Johnny H, Pei, Charles, Kong, Wei-Jia, Liu, Xuezhong, Wu, Hao, Kleinstiver, Benjamin P, Liu, David R, Chen, Zheng-Yi
Published in Nature communications (15.08.2023)
Published in Nature communications (15.08.2023)
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Journal Article
Inducible and multiplex gene regulation using CRISPR-Cpf1-based transcription factors
Tak, Y Esther, Kleinstiver, Benjamin P, Nuñez, James K, Hsu, Jonathan Y, Horng, Joy E, Gong, Jingyi, Weissman, Jonathan S, Joung, J Keith
Published in Nature methods (01.12.2017)
Published in Nature methods (01.12.2017)
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Journal Article
Engineered CRISPR-Cas9 nucleases with altered PAM specificities
Kleinstiver, Benjamin P, Prew, Michelle S, Tsai, Shengdar Q, Topkar, Ved V, Nguyen, Nhu T, Zheng, Zongli, Gonzales, Andrew P W, Li, Zhuyun, Peterson, Randall T, Yeh, Jing-Ruey Joanna, Aryee, Martin J, Joung, J Keith
Published in Nature (London) (23.07.2015)
Published in Nature (London) (23.07.2015)
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