SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Hoffmann, Markus, Kleine-Weber, Hannah, Schroeder, Simon, Krüger, Nadine, Herrler, Tanja, Erichsen, Sandra, Schiergens, Tobias S., Herrler, Georg, Wu, Nai-Huei, Nitsche, Andreas, Müller, Marcel A., Drosten, Christian, Pöhlmann, Stefan
Published in Cell (16.04.2020)
Published in Cell (16.04.2020)
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Functional analysis of potential cleavage sites in the MERS-coronavirus spike protein
Kleine-Weber, Hannah, Elzayat, Mahmoud Tarek, Hoffmann, Markus, Pöhlmann, Stefan
Published in Scientific reports (09.11.2018)
Published in Scientific reports (09.11.2018)
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SARS-CoV-2 mutations acquired in mink reduce antibody-mediated neutralization
Hoffmann, Markus, Zhang, Lu, Krüger, Nadine, Graichen, Luise, Kleine-Weber, Hannah, Hofmann-Winkler, Heike, Kempf, Amy, Nessler, Stefan, Riggert, Joachim, Winkler, Martin Sebastian, Schulz, Sebastian, Jäck, Hans-Martin, Pöhlmann, Stefan
Published in Cell reports (Cambridge) (20.04.2021)
Published in Cell reports (Cambridge) (20.04.2021)
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LY6E impairs coronavirus fusion and confers immune control of viral disease
Pfaender, Stephanie, Mar, Katrina B., Michailidis, Eleftherios, Kratzel, Annika, Boys, Ian N., V’kovski, Philip, Fan, Wenchun, Kelly, Jenna N., Hirt, Dagny, Ebert, Nadine, Stalder, Hanspeter, Kleine-Weber, Hannah, Hoffmann, Markus, Hoffmann, Hans-Heinrich, Saeed, Mohsan, Dijkman, Ronald, Steinmann, Eike, Wight-Carter, Mary, McDougal, Matthew B., Hanners, Natasha W., Pöhlmann, Stefan, Gallagher, Tom, Todt, Daniel, Zimmer, Gert, Rice, Charles M., Schoggins, John W., Thiel, Volker
Published in Nature microbiology (01.11.2020)
Published in Nature microbiology (01.11.2020)
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Polymorphisms in dipeptidyl peptidase 4 reduce host cell entry of Middle East respiratory syndrome coronavirus
Kleine-Weber, Hannah, Schroeder, Simon, Krüger, Nadine, Prokscha, Alexander, Naim, Hassan Y., Müller, Marcel A., Drosten, Christian, Pöhlmann, Stefan, Hoffmann, Markus
Published in Emerging microbes & infections (01.01.2020)
Published in Emerging microbes & infections (01.01.2020)
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Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5
Schroeder, Simon, Mache, Christin, Kleine-Weber, Hannah, Corman, Victor M., Muth, Doreen, Richter, Anja, Fatykhova, Diana, Memish, Ziad A., Stanifer, Megan L., Boulant, Steeve, Gultom, Mitra, Dijkman, Ronald, Eggeling, Stephan, Hocke, Andreas, Hippenstiel, Stefan, Thiel, Volker, Pöhlmann, Stefan, Wolff, Thorsten, Müller, Marcel A., Drosten, Christian
Published in Nature communications (07.09.2021)
Published in Nature communications (07.09.2021)
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Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2
Hoffmann, Markus, Mösbauer, Kirstin, Hofmann-Winkler, Heike, Kaul, Artur, Kleine-Weber, Hannah, Krüger, Nadine, Gassen, Nils C., Müller, Marcel A., Drosten, Christian, Pöhlmann, Stefan
Published in Nature (London) (24.09.2020)
Published in Nature (London) (24.09.2020)
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SARS-CoV-2 and SARS-CoV Spike-Mediated Cell-Cell Fusion Differ in Their Requirements for Receptor Expression and Proteolytic Activation
Hörnich, Bojan F, Großkopf, Anna K, Schlagowski, Sarah, Tenbusch, Matthias, Kleine-Weber, Hannah, Neipel, Frank, Stahl-Hennig, Christiane, Hahn, Alexander S
Published in Journal of virology (12.04.2021)
Published in Journal of virology (12.04.2021)
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Mutations in the Spike Protein of Middle East Respiratory Syndrome Coronavirus Transmitted in Korea Increase Resistance to Antibody-Mediated Neutralization
Kleine-Weber, Hannah, Elzayat, Mahmoud Tarek, Wang, Lingshu, Graham, Barney S, Müller, Marcel A, Drosten, Christian, Pöhlmann, Stefan, Hoffmann, Markus
Published in Journal of virology (15.01.2019)
Published in Journal of virology (15.01.2019)
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Acquisition of a multibasic cleavage site does not increase MERS-CoV entry into Calu-3 human lung cells
Hoffmann, Markus, Kleine-Weber, Hannah, Graichen, Luise, Nehlmeier, Inga, Kempf, Amy, Moldenhauer, Anna-Sophie, Braun, Elisabeth, Assiri, Abdullah M, Kirchhoff, Frank, Sauter, Daniel, Alkharsah, Khaled R, Pöhlmann, Stefan
Published in Journal of virology (19.11.2024)
Published in Journal of virology (19.11.2024)
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SARS-CoV-2 and SARS-CoV spike-mediated cell-cell fusion differ in the requirements for receptor expression and proteolytic activation
Hörnich, Bojan F, Großkopf, Anna K, Schlagowski, Sarah, Tenbusch, Matthias, Kleine-Weber, Hannah, Neipel, Frank, Stahl-Hennig, Christiane, Hahn, Alexander S
Published in bioRxiv (15.02.2021)
Published in bioRxiv (15.02.2021)
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Low serum neutralizing anti-SARS-CoV-2 S antibody levels in mildly affected COVID-19 convalescent patients revealed by two different detection methods
Bošnjak, Berislav, Stein, Saskia Catherina, Willenzon, Stefanie, Cordes, Anne Katrin, Puppe, Wolfram, Bernhardt, Günter, Ravens, Inga, Ritter, Christiane, Schultze-Florey, Christian R., Gödecke, Nina, Martens, Jörg, Kleine-Weber, Hannah, Hoffmann, Markus, Cossmann, Anne, Yilmaz, Mustafa, Pink, Isabelle, Hoeper, Marius M., Behrens, Georg M. N., Pöhlmann, Stefan, Blasczyk, Rainer, Schulz, Thomas F., Förster, Reinhold
Published in Cellular & molecular immunology (01.04.2021)
Published in Cellular & molecular immunology (01.04.2021)
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A human monoclonal antibody neutralizing SARS-CoV-2 Omicron variants containing the L452R mutation
Stein, Saskia C, Hansen, Guido, Ssebyatika, George, Ströh, Luisa J, Ochulor, Okechukwu, Herold, Elisabeth, Schwarzloh, Britta, Mutschall, Doris, Zischke, Jasmin, Cordes, Anne K, Schneider, Talia, Hinrichs, Imke, Blasczyk, Rainer, Kleine-Weber, Hannah, Hoffmann, Markus, Klein, Florian, Kaiser, Franziska K, Gonzalez-Hernandez, Mariana, Armando, Federico, Ciurkiewicz, Malgorzata, Beythien, Georg, Pöhlmann, Stefan, Baumgärtner, Wolfgang, Osterhaus, Albert, Schulz, Thomas F, Krey, Thomas
Published in Journal of virology (04.11.2024)
Published in Journal of virology (04.11.2024)
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The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells
Hoffmann, Markus, Kleine-Weber, Hannah, Krueger, Nadine, Mueller, Marcel A, Drosten, Christian, Poehlmann, Stefan
Published in bioRxiv (31.01.2020)
Published in bioRxiv (31.01.2020)
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SARS-CoV-2 mutations acquired in mink reduce antibody-mediated neutralization
Hoffmann, Markus, Zhang, Lu, Krüger, Nadine, Graichen, Luise, Kleine-Weber, Hannah, Hofmann-Winkler, Heike, Kempf, Amy, Nessler, Stefan, Riggert, Joachim, Winkler, Martin Sebastian, Schulz, Sebastian, Hans-Martin Jäck, Pöhlmann, Stefan
Published in bioRxiv (12.02.2021)
Published in bioRxiv (12.02.2021)
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Polymorphisms in dipeptidyl peptidase 4 reduce host cell entry of Middle East respiratory syndrome coronavirus
Kleine-Weber, Hannah, Schroeder, Simon, Krüger, Nadine, Prokscha, Alexander, Naim, Hassan Y, Müller, Marcel A, Drosten, Christian, Pöhlmann, Stefan, Hoffmann, Markus
Published in Emerging Microbes & Infections (21.01.2020)
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Published in Emerging Microbes & Infections (21.01.2020)
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