The mechanistic and functional profile of the therapeutic anti-IgE antibody ligelizumab differs from omalizumab
Gasser, Pascal, Tarchevskaya, Svetlana S., Guntern, Pascal, Brigger, Daniel, Ruppli, Rahel, Zbären, Noemi, Kleinboelting, Silke, Heusser, Christoph, Jardetzky, Theodore S., Eggel, Alexander
Published in Nature communications (08.01.2020)
Published in Nature communications (08.01.2020)
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Journal Article
Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex
Pennington, Luke F., Gasser, Pascal, Kleinboelting, Silke, Zhang, Chensong, Skiniotis, Georgios, Eggel, Alexander, Jardetzky, Theodore S.
Published in Nature communications (03.12.2021)
Published in Nature communications (03.12.2021)
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Journal Article
Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate
Kleinboelting, Silke, Diaz, Ana, Moniot, Sebastien, van den Heuvel, Joop, Weyand, Michael, Levin, Lonny R., Buck, Jochen, Steegborn, Clemens
Published in Proceedings of the National Academy of Sciences - PNAS (11.03.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (11.03.2014)
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Journal Article
Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase
Ramos-Espiritu, Lavoisier, Kleinboelting, Silke, Navarrete, Felipe A, Alvau, Antonio, Visconti, Pablo E, Valsecchi, Federica, Starkov, Anatoly, Manfredi, Giovanni, Buck, Hannes, Adura, Carolina, Zippin, Jonathan H, van den Heuvel, Joop, Glickman, J Fraser, Steegborn, Clemens, Levin, Lonny R, Buck, Jochen
Published in Nature chemical biology (01.10.2016)
Published in Nature chemical biology (01.10.2016)
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Journal Article
Optimization of Covalent MKK7 Inhibitors via Crude Nanomole-Scale Libraries
Gehrtz, Paul, Marom, Shir, Bührmann, Mike, Hardick, Julia, Kleinbölting, Silke, Shraga, Amit, Dubiella, Christian, Gabizon, Ronen, Wiese, Jan N., Müller, Matthias P., Cohen, Galit, Babaev, Ilana, Shurrush, Khriesto, Avram, Liat, Resnick, Efrat, Barr, Haim, Rauh, Daniel, London, Nir
Published in Journal of medicinal chemistry (11.08.2022)
Published in Journal of medicinal chemistry (11.08.2022)
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A Universal Stress Protein (USP) in Mycobacteria Binds cAMP
Banerjee, Arka, Adolph, Ramona S., Gopalakrishnapai, Jayashree, Kleinboelting, Silke, Emmerich, Christiane, Steegborn, Clemens, Visweswariah, Sandhya S.
Published in The Journal of biological chemistry (15.05.2015)
Published in The Journal of biological chemistry (15.05.2015)
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Addressing the Osimertinib Resistance Mutation EGFR-L858R/C797S with Reversible Aminopyrimidines
Grabe, Tobias, Jeyakumar, Kirujan, Niggenaber, Janina, Schulz, Tom, Koska, Sandra, Kleinbölting, Silke, Beck, Michael Edmund, Müller, Matthias P., Rauh, Daniel
Published in ACS medicinal chemistry letters (11.05.2023)
Published in ACS medicinal chemistry letters (11.05.2023)
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Journal Article
Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site
Kleinboelting, Silke, Ramos-Espiritu, Lavoisier, Buck, Hannes, Colis, Laureen, van den Heuvel, Joop, Glickman, J. Fraser, Levin, Lonny R., Buck, Jochen, Steegborn, Clemens
Published in The Journal of biological chemistry (29.04.2016)
Published in The Journal of biological chemistry (29.04.2016)
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Journal Article
Expression, purification, crystallization and preliminary X-ray diffraction analysis of a mammalian type 10 adenylyl cyclase
Kleinboelting, Silke, van den Heuvel, Joop, Kambach, Christian, Weyand, Michael, Leipelt, Martina, Steegborn, Clemens
Published in Acta crystallographica. Section F, Structural biology communications (01.04.2014)
Published in Acta crystallographica. Section F, Structural biology communications (01.04.2014)
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Structure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complex
Bashiri, Ghader, Johnston, Jodie M., Evans, Genevieve L., Bulloch, Esther M. M., Goldstone, David C., Jirgis, Ehab N. M., Kleinboelting, Silke, Castell, Alina, Ramsay, Rochelle J., Manos-Turvey, Alexandra, Payne, Richard J., Lott, J. Shaun, Baker, Edward N.
Published in Acta crystallographica. Section D, Biological crystallography. (01.11.2015)
Published in Acta crystallographica. Section D, Biological crystallography. (01.11.2015)
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