Unraveling the Complex Interplay Between T Cell Metabolism and Function
Klein Geltink, Ramon I, Kyle, Ryan L, Pearce, Erika L
Published in Annual review of immunology (26.04.2018)
Published in Annual review of immunology (26.04.2018)
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Journal Article
Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming
Buck, Michael D., O’Sullivan, David, Klein Geltink, Ramon I., Curtis, Jonathan D., Chang, Chih-Hao, Sanin, David E., Qiu, Jing, Kretz, Oliver, Braas, Daniel, van der Windt, Gerritje J.W., Chen, Qiongyu, Huang, Stanley Ching-Cheng, O’Neill, Christina M., Edelson, Brian T., Pearce, Edward J., Sesaki, Hiromi, Huber, Tobias B., Rambold, Angelika S., Pearce, Erika L.
Published in Cell (30.06.2016)
Published in Cell (30.06.2016)
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Triacylglycerol synthesis enhances macrophage inflammatory function
Castoldi, Angela, Monteiro, Lauar B., van Teijlingen Bakker, Nikki, Sanin, David E., Rana, Nisha, Corrado, Mauro, Cameron, Alanna M., Hässler, Fabian, Matsushita, Mai, Caputa, George, Klein Geltink, Ramon I., Büscher, Jörg, Edwards-Hicks, Joy, Pearce, Erika L., Pearce, Edward J.
Published in Nature communications (14.08.2020)
Published in Nature communications (14.08.2020)
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Journal Article
Acetate Promotes T Cell Effector Function during Glucose Restriction
Qiu, Jing, Villa, Matteo, Sanin, David E., Buck, Michael D., O’Sullivan, David, Ching, Reagan, Matsushita, Mai, Grzes, Katarzyna M., Winkler, Frances, Chang, Chih-Hao, Curtis, Jonathan D., Kyle, Ryan L., Van Teijlingen Bakker, Nikki, Corrado, Mauro, Haessler, Fabian, Alfei, Francesca, Edwards-Hicks, Joy, Maggi, Leonard B., Zehn, Dietmar, Egawa, Takeshi, Bengsch, Bertram, Klein Geltink, Ramon I., Jenuwein, Thomas, Pearce, Edward J., Pearce, Erika L.
Published in Cell reports (Cambridge) (14.05.2019)
Published in Cell reports (Cambridge) (14.05.2019)
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Journal Article
Fever supports CD8⁺ effector T cell responses by promoting mitochondrial translation
O’Sullivan, David, Stanczak, Michal A., Villa, Matteo, Uhl, Franziska M., Corrado, Mauro, Geltink, Ramon I. Klein, Sanin, David E., Apostolova, Petya, Rana, Nisha, Edwards-Hicks, Joy, Grzes, Katarzyna M., Kabat, Agnieszka M., Kyle, Ryan L., Fabri, Mario, Curtis, Jonathan D., Buck, Michael D., Patterson, Annette E., Regina, Annamaria, Field, Cameron S., Baixauli, Francesc, Puleston, Daniel J., Pearce, Edward J., Zeiser, Robert, Pearce, Erika L.
Published in Proceedings of the National Academy of Sciences - PNAS (22.06.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (22.06.2021)
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Alanine supplementation exploits glutamine dependency induced by SMARCA4/2-loss
Zhu, Xianbing, Fu, Zheng, Chen, Shary Y., Ong, Dionzie, Aceto, Giulio, Ho, Rebecca, Steinberger, Jutta, Monast, Anie, Pilon, Virginie, Li, Eunice, Ta, Monica, Ching, Kyle, Adams, Bianca N., Negri, Gian L., Choiniere, Luc, Fu, Lili, Pavlakis, Kitty, Pirrotte, Patrick, Avizonis, Daina Z., Trent, Jeffrey, Weissman, Bernard E., Klein Geltink, Ramon I., Morin, Gregg B., Park, Morag, Huntsman, David G., Foulkes, William D., Wang, Yemin, Huang, Sidong
Published in Nature communications (20.05.2023)
Published in Nature communications (20.05.2023)
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Journal Article
ETV7 is an essential component of a rapamycin-insensitive mTOR complex in cancer
Harwood, Franklin C, Klein Geltink, Ramon I, O'Hara, Brendan P, Cardone, Monica, Janke, Laura, Finkelstein, David, Entin, Igor, Paul, Leena, Houghton, Peter J, Grosveld, Gerard C
Published in Science advances (01.09.2018)
Published in Science advances (01.09.2018)
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Journal Article
A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways
Piragyte, Indre, Clapes, Thomas, Polyzou, Aikaterini, Klein Geltink, Ramon I., Lefkopoulos, Stylianos, Yin, Na, Cauchy, Pierre, Curtis, Jonathan D., Klaeylé, Lhéanna, Langa, Xavier, Beckmann, Cora C. A., Wlodarski, Marcin W., Müller, Patrick, Van Essen, Dominic, Rambold, Angelika, Kapp, Friedrich G., Mione, Marina, Buescher, Joerg M., Pearce, Erika L., Polyzos, Alexander, Trompouki, Eirini
Published in Nature communications (06.08.2018)
Published in Nature communications (06.08.2018)
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Journal Article
Transsulfuration, minor player or crucial for cysteine homeostasis in cancer
Zhang, Hai-Feng, Klein Geltink, Ramon I., Parker, Seth J., Sorensen, Poul H.
Published in Trends in cell biology (01.09.2022)
Published in Trends in cell biology (01.09.2022)
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Journal Article
Mitochondrial Priming by CD28
Klein Geltink, Ramon I, O'Sullivan, David, Corrado, Mauro, Bremser, Anna, Buck, Michael D, Buescher, Joerg M, Firat, Elke, Zhu, Xuekai, Niedermann, Gabriele, Caputa, George, Kelly, Beth, Warthorst, Ursula, Rensing-Ehl, Anne, Kyle, Ryan L, Vandersarren, Lana, Curtis, Jonathan D, Patterson, Annette E, Lawless, Simon, Grzes, Katarzyna, Qiu, Jing, Sanin, David E, Kretz, Oliver, Huber, Tobias B, Janssens, Sophie, Lambrecht, Bart N, Rambold, Angelika S, Pearce, Edward J, Pearce, Erika L
Published in Cell (05.10.2017)
Published in Cell (05.10.2017)
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Journal Article
Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2
Sanin, David E., Matsushita, Mai, Klein Geltink, Ramon I., Grzes, Katarzyna M., van Teijlingen Bakker, Nikki, Corrado, Mauro, Kabat, Agnieszka M., Buck, Michael D., Qiu, Jing, Lawless, Simon J., Cameron, Alanna M., Villa, Matteo, Baixauli, Francesc, Patterson, Annette E., Hässler, Fabian, Curtis, Jonathan D., O’Neill, Christina M., O’Sullivan, David, Wu, Duojiao, Mittler, Gerhard, Huang, Stanley Ching-Cheng, Pearce, Erika L., Pearce, Edward J.
Published in Immunity (Cambridge, Mass.) (18.12.2018)
Published in Immunity (Cambridge, Mass.) (18.12.2018)
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Journal Article
Caught in the cROSsfire: GSH Controls T Cell Metabolic Reprogramming
Klein Geltink, Ramon I., O’Sullivan, David, Pearce, Erika L.
Published in Immunity (Cambridge, Mass.) (18.04.2017)
Published in Immunity (Cambridge, Mass.) (18.04.2017)
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Journal Article
A low-sugar diet enhances Drosophila body size in males and females via sex-specific mechanisms
Millington, Jason W, Biswas, Puja, Chao, Charlotte, Xia, Yi Han, Wat, Lianna W, Brownrigg, George P, Sun, Ziwei, Basner-Collins, Paige J, Klein Geltink, Ramon I, Rideout, Elizabeth J
Published in Development (Cambridge) (15.03.2022)
Published in Development (Cambridge) (15.03.2022)
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Journal Article
Phosphoinositide acyl chain saturation drives CD8+ effector T cell signaling and function
Edwards-Hicks, Joy, Apostolova, Petya, Buescher, Joerg M., Maib, Hannes, Stanczak, Michal A., Corrado, Mauro, Klein Geltink, Ramon I., Maccari, Maria Elena, Villa, Matteo, Carrizo, Gustavo E., Sanin, David E., Baixauli, Francesc, Kelly, Beth, Curtis, Jonathan D., Haessler, Fabian, Patterson, Annette, Field, Cameron S., Caputa, George, Kyle, Ryan L., Soballa, Melanie, Cha, Minsun, Paul, Harry, Martin, Jacob, Grzes, Katarzyna M., Flachsmann, Lea, Mitterer, Michael, Zhao, Liang, Winkler, Frances, Rafei-Shamsabadi, David Ali, Meiss, Frank, Bengsch, Bertram, Zeiser, Robert, Puleston, Daniel J., O’Sullivan, David, Pearce, Edward J., Pearce, Erika L.
Published in Nature immunology (01.03.2023)
Published in Nature immunology (01.03.2023)
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Journal Article
Consequences of adjusting cell density and feed frequency on serum-free expansion of thymic regulatory T cells
MacDonald, Katherine N., Hall, Michael G., Ivison, Sabine, Gandhi, Sanjiv, Klein Geltink, Ramon I., Piret, James M., Levings, Megan K.
Published in Cytotherapy (Oxford, England) (01.11.2022)
Published in Cytotherapy (Oxford, England) (01.11.2022)
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Journal Article
Metabolic conditioning of CD8 + effector T cells for adoptive cell therapy
Klein Geltink, Ramon I, Edwards-Hicks, Joy, Apostolova, Petya, O'Sullivan, David, Sanin, David E, Patterson, Annette E, Puleston, Daniel J, Ligthart, Nina A M, Buescher, Joerg M, Grzes, Katarzyna M, Kabat, Agnieszka M, Stanczak, Michal, Curtis, Jonathan D, Hässler, Fabian, Uhl, Franziska M, Fabri, Mario, Zeiser, Robert, Pearce, Edward J, Pearce, Erika L
Published in Nature metabolism (01.08.2020)
Published in Nature metabolism (01.08.2020)
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IL-27 signalling regulates glycolysis in Th1 cells to limit immunopathology during infection
Montes de Oca, Marcela, de Labastida Rivera, Fabian, Winterford, Clay, Frame, Teija C M, Ng, Susanna S, Amante, Fiona H, Edwards, Chelsea L, Bukali, Luzia, Wang, Yulin, Uzonna, Jude E, Kuns, Rachel D, Zhang, Ping, Kabat, Agnieszka, Klein Geltink, Ramon I, Pearce, Edward J, Hill, Geoffrey R, Engwerda, Christian R
Published in PLoS pathogens (13.10.2020)
Published in PLoS pathogens (13.10.2020)
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