C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease
Dufour, Antoine, Bellac, Caroline L., Eckhard, Ulrich, Solis, Nestor, Klein, Theo, Kappelhoff, Reinhild, Fortelny, Nikolaus, Jobin, Parker, Rozmus, Jacob, Mark, Jennifer, Pavlidis, Paul, Dive, Vincent, Barbour, Sean J., Overall, Christopher M.
Published in Nature communications (20.06.2018)
Published in Nature communications (20.06.2018)
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Journal Article
DIPPER, a spatiotemporal proteomics atlas of human intervertebral discs for exploring ageing and degeneration dynamics
Tam, Vivian, Chen, Peikai, Yee, Anita, Solis, Nestor, Klein, Theo, Kudelko, Mateusz, Sharma, Rakesh, Chan, Wilson Cw, Overall, Christopher M, Haglund, Lisbet, Sham, Pak C, Cheah, Kathryn Song Eng, Chan, Danny
Published in eLife (31.12.2020)
Published in eLife (31.12.2020)
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Journal Article
Lipid signature of advanced human carotid atherosclerosis assessed by mass spectrometry imaging
Moerman, Astrid M., Visscher, Mirjam, Slijkhuis, Nuria, Van Gaalen, Kim, Heijs, Bram, Klein, Theo, Burgers, Peter C., De Rijke, Yolanda B., Van Beusekom, Heleen M.M., Luider, Theo M., Verhagen, Hence J.M., Van der Steen, Antonius F.W., Gijsen, Frank J.H., Van der Heiden, Kim, Van Soest, Gijs
Published in Journal of lipid research (01.01.2021)
Published in Journal of lipid research (01.01.2021)
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Journal Article
An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient
Quancard, Jean, Klein, Theo, Fung, Shan-Yu, Renatus, Martin, Hughes, Nicola, Israël, Laura, Priatel, John J., Kang, Sohyeong, Blank, Michael A., Viner, Rosa I., Blank, Jutta, Schlapbach, Achim, Erbel, Paul, Kizhakkedathu, Jayachandran, Villard, Frédéric, Hersperger, René, Turvey, Stuart E., Eder, Joerg, Bornancin, Frédéric, Overall, Christopher M.
Published in Nature chemical biology (01.03.2019)
Published in Nature chemical biology (01.03.2019)
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Journal Article
A Mass Spectrometry-Based Panel of Nine Thyroid Hormone Metabolites in Human Serum
Jongejan, Rutchanna M S, Klein, Theo, Meima, Marcel E, Visser, W Edward, van Heerebeek, Ramona E A, Luider, Theo M, Peeters, Robin P, de Rijke, Yolanda B
Published in Clinical chemistry (Baltimore, Md.) (01.04.2020)
Published in Clinical chemistry (Baltimore, Md.) (01.04.2020)
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Journal Article
Granzyme B is elevated in autoimmune blistering diseases and cleaves key anchoring proteins of the dermal-epidermal junction
Russo, Valerio, Klein, Theo, Lim, Darielle J., Solis, Nestor, Machado, Yoan, Hiroyasu, Sho, Nabai, Layla, Shen, Yue, Zeglinski, Matthew R., Zhao, Hongyan, Oram, Cameron P., Lennox, Peter A., Van Laeken, Nancy, Carr, Nick J., Crawford, Richard I., Franzke, Claus-Werner, Overall, Christopher M., Granville, David J.
Published in Scientific reports (26.06.2018)
Published in Scientific reports (26.06.2018)
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Journal Article
Kynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Rα
Cai, Zongye, Tian, Siyu, Klein, Theo, Tu, Ly, Geenen, Laurie W., Koudstaal, Thomas, van den Bosch, Annemien E., de Rijke, Yolanda B., Reiss, Irwin K. M., Boersma, Eric, van der Ley, Claude, Van Faassen, Martijn, Kema, Ido, Duncker, Dirk J., Boomars, Karin A., Tran-Lundmark, Karin, Guignabert, Christophe, Merkus, Daphne
Published in Scientific reports (19.07.2022)
Published in Scientific reports (19.07.2022)
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Journal Article
MALT1-Dependent Cleavage of HOIL1 Modulates Canonical NF-κB Signaling and Inflammatory Responsiveness
Fung, Shan-Yu, Lu, Henry Y, Sharma, Mehul, Sharma, Ashish A, Saferali, Aabida, Jia, Alicia, Abraham, Libin, Klein, Theo, Gold, Michael R, Noterangelo, Luigi D, Overall, Christopher M, Turvey, Stuart E
Published in Frontiers in immunology (14.10.2021)
Published in Frontiers in immunology (14.10.2021)
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Journal Article
Master Sculptor at Work: Enteropathogenic Escherichia coli Infection Uniquely Modifies Mitochondrial Proteolysis during Its Control of Human Cell Death
Marshall, Natalie C., Thejoe, Maichael, Klein, Theo, Serapio-Palacios, Antonio, Santos, Andrew S., von Krosigk, Niklas, Kizhakkedathu, Jayachandran N., Stoynov, Nikolay, Foster, Leonard J., Overall, Christopher M., Finlay, B. Brett
Published in mSystems (02.06.2020)
Published in mSystems (02.06.2020)
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Journal Article
Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14
Eckhard, Ulrich, Huesgen, Pitter F., Schilling, Oliver, Bellac, Caroline L., Butler, Georgina S., Cox, Jennifer H., Dufour, Antoine, Goebeler, Verena, Kappelhoff, Reinhild, auf dem Keller, Ulrich, Klein, Theo, Lange, Philipp F., Marino, Giada, Morrison, Charlotte J., Prudova, Anna, Rodriguez, David, Starr, Amanda E., Wang, Yili, Overall, Christopher M.
Published in Data in brief (01.06.2016)
Published in Data in brief (01.06.2016)
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Journal Article
Solid-Phase Synthesis of Succinylhydroxamate Peptides: Functionalized Matrix Metalloproteinase Inhibitors
Leeuwenburgh, Michiel A, Geurink, Paul P, Klein, Theo, Kauffman, Henk F, van der Marel, Gijs A, Bischoff, Rainer, Overkleeft, Herman S
Published in Organic letters (13.04.2006)
Published in Organic letters (13.04.2006)
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Journal Article
N-Terminomics TAILS Identifies Host Cell Substrates of Poliovirus and Coxsackievirus B3 3C Proteinases That Modulate Virus Infection
Jagdeo, Julienne M, Dufour, Antoine, Klein, Theo, Solis, Nestor, Kleifeld, Oded, Kizhakkedathu, Jayachandran, Luo, Honglin, Overall, Christopher M, Jan, Eric
Published in Journal of virology (15.04.2018)
Published in Journal of virology (15.04.2018)
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Journal Article
Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses
Eckhard, Ulrich, Huesgen, Pitter F., Schilling, Oliver, Bellac, Caroline L., Butler, Georgina S., Cox, Jennifer H., Dufour, Antoine, Goebeler, Verena, Kappelhoff, Reinhild, Keller, Ulrich auf dem, Klein, Theo, Lange, Philipp F., Marino, Giada, Morrison, Charlotte J., Prudova, Anna, Rodriguez, David, Starr, Amanda E., Wang, Yili, Overall, Christopher M.
Published in Matrix biology (01.01.2016)
Published in Matrix biology (01.01.2016)
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Journal Article
The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling
Klein, Theo, Fung, Shan-Yu, Renner, Florian, Blank, Michael A., Dufour, Antoine, Kang, Sohyeong, Bolger-Munro, Madison, Scurll, Joshua M., Priatel, John J., Schweigler, Patrick, Melkko, Samu, Gold, Michael R., Viner, Rosa I., Régnier, Catherine H., Turvey, Stuart E., Overall, Christopher M.
Published in Nature communications (03.11.2015)
Published in Nature communications (03.11.2015)
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Journal Article
Cross-Laboratory Standardization of Preclinical Lipidomics Using Differential Mobility Spectrometry and Multiple Reaction Monitoring
Ghorasaini, Mohan, Mohammed, Yassene, Adamski, Jerzy, Bettcher, Lisa, Bowden, John A, Cabruja, Matias, Contrepois, Kévin, Ellenberger, Mathew, Gajera, Bharat, Haid, Mark, Hornburg, Daniel, Hunter, Christie, Jones, Christina M, Klein, Theo, Mayboroda, Oleg, Mirzaian, Mina, Moaddel, Ruin, Ferrucci, Luigi, Lovett, Jacqueline, Nazir, Kenneth, Pearson, Mackenzie, Ubhi, Baljit K, Raftery, Daniel, Riols, Fabien, Sayers, Rebekah, Sijbrands, Eric J. G, Snyder, Michael P, Su, Baolong, Velagapudi, Vidya, Williams, Kevin J, de Rijke, Yolanda B, Giera, Martin
Published in Analytical chemistry (Washington) (14.12.2021)
Published in Analytical chemistry (Washington) (14.12.2021)
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Journal Article
L-Tryptophan–Induced Vasodilation Is Enhanced in Preeclampsia: Studies on Its Uptake and Metabolism in the Human Placenta
Broekhuizen, Michelle, Klein, Theo, Hitzerd, Emilie, de Rijke, Yolanda B, Schoenmakers, Sam, Sedlmayr, Peter, Danser, A.H Jan, Merkus, Daphne, Reiss, Irwin K.M
Published in Hypertension (Dallas, Tex. 1979) (01.07.2020)
Published in Hypertension (Dallas, Tex. 1979) (01.07.2020)
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Journal Article
Global Profiling of Proteolysis from the Mitochondrial Amino Terminome during Early Intrinsic Apoptosis Prior to Caspase‑3 Activation
Marshall, Natalie C, Klein, Theo, Thejoe, Maichael, von Krosigk, Niklas, Kizhakkedathu, Jayachandran, Finlay, B. Brett, Overall, Christopher M
Published in Journal of proteome research (07.12.2018)
Published in Journal of proteome research (07.12.2018)
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Journal Article
TAILS proteomics reveals dynamic changes in airway proteolysis controlling protease activity and innate immunity during COPD exacerbations
Mallia-Milanes, Brendan, Dufour, Antoine, Philp, Christopher, Solis, Nestor, Klein, Theo, Fischer, Marlies, Bolton, Charlotte E, Shapiro, Steven, Overall, Christopher M, Johnson, Simon R
Published in American journal of physiology. Lung cellular and molecular physiology (01.12.2018)
Published in American journal of physiology. Lung cellular and molecular physiology (01.12.2018)
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