Chemical space docking enables large-scale structure-based virtual screening to discover ROCK1 kinase inhibitors
Beroza, Paul, Crawford, James J., Ganichkin, Oleg, Gendelev, Leo, Harris, Seth F., Klein, Raphael, Miu, Anh, Steinbacher, Stefan, Klingler, Franca-Maria, Lemmen, Christian
Published in Nature communications (28.10.2022)
Published in Nature communications (28.10.2022)
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Journal Article
In silico identification and experimental validation of hits active against KPC-2 β-lactamase
Klein, Raphael, Linciano, Pasquale, Celenza, Giuseppe, Bellio, Pierangelo, Papaioannou, Sofia, Blazquez, Jesus, Cendron, Laura, Brenk, Ruth, Tondi, Donatella
Published in PloS one (29.11.2018)
Published in PloS one (29.11.2018)
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Journal Article
association between milk and slime increases biofilm production by bovine Staphylococcus aureus
Fabres-Klein, Mary Hellen, Caizer Santos, Mário Junior, Contelli Klein, Raphael, Nunes de Souza, Guilherme, de Oliveira Barros Ribon, Andrea
Published in BMC veterinary research (16.01.2015)
Published in BMC veterinary research (16.01.2015)
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Journal Article
Modulation of the Serotonergic Receptosome in the Treatment of Anxiety and Depression: A Narrative Review of the Experimental Evidence
Villas-Boas, Gustavo R, Lavorato, Stefânia N, Paes, Marina M, de Carvalho, Pablinny M G, Rescia, Vanessa C, Cunha, Mila S, de Magalhães-Filho, Manoel F, Ponsoni, Luis F, de Carvalho, Adryano Augustto Valladao, de Lacerda, Roseli B, da S Leite, Lais, da S Tavares-Henriques, Matheus, Lopes, Luiz A F, Oliveira, Luiz G R, Silva-Filho, Saulo E, da Silveira, Ana P S, Cuman, Roberto K N, de S Silva-Comar, Francielli M, Comar, Jurandir F, do A Brasileiro, Luana, Dos Santos, Jussileide N, de Freitas, William R, Leão, Katyuscya V, da Silva, Jonatas G, Klein, Raphael C, Klein, Mary H F, da S Ramos, Bruno H, Fernandes, Cristiane K C, de L Ribas, Dayane G, Oesterreich, Silvia A
Published in Pharmaceuticals (Basel, Switzerland) (12.02.2021)
Published in Pharmaceuticals (Basel, Switzerland) (12.02.2021)
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Journal Article
Concomitant Benznidazole and Suramin Chemotherapy in Mice Infected with a Virulent Strain of Trypanosoma cruzi
Santos, Eliziária C, Novaes, Rômulo D, Cupertino, Marli C, Bastos, Daniel S S, Klein, Raphael C, Silva, Eduardo A M, Fietto, Juliana L R, Talvani, André, Bahia, Maria T, Oliveira, Leandro L
Published in Antimicrobial agents and chemotherapy (01.10.2015)
Published in Antimicrobial agents and chemotherapy (01.10.2015)
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Journal Article
A deep insight into the whole transcriptome of midguts, ovaries and salivary glands of the Amblyomma sculptum tick
Moreira, Higo Nasser Santanna, Barcelos, Rafael Mazioli, Vidigal, Pedro Marcus Pereira, Klein, Raphael Contelli, Montandon, Carlos Emmanuel, Maciel, Talles Eduardo Ferreira, Carrizo, Juliana Fernandes Areal, de Lima, Paulo Henrique Costa, Soares, Adriano Carlos, Martins, Maria Marlene, Mafra, Cláudio
Published in Parasitology international (01.04.2017)
Published in Parasitology international (01.04.2017)
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Journal Article
Targeting the Class A Carbapenemase GES-5 via Virtual Screening
Klein, Raphael, Cendron, Laura, Montanari, Martina, Bellio, Pierangelo, Celenza, Giuseppe, Maso, Lorenzo, Tondi, Donatella, Brenk, Ruth
Published in Biomolecules (Basel, Switzerland) (14.02.2020)
Published in Biomolecules (Basel, Switzerland) (14.02.2020)
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Journal Article
Fomites and the environment did not have an important role in COVID-19 transmission in a Brazilian mid-sized city
Rocha, Ana Luíza Silva, Pinheiro, Josilene Ramos, Nakamura, Thamilin Costa, da Silva, José Domingos Santos, Rocha, Beatriz Gonçalves Silva, Klein, Raphael Contelli, Birbrair, Alexander, Amorim, Jaime Henrique
Published in Scientific reports (05.08.2021)
Published in Scientific reports (05.08.2021)
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Journal Article
Staphylococcus aureus of bovine origin: Genetic diversity, prevalence and the expression of adhesin-encoding genes
Klein, Raphael Contelli, Fabres-Klein, Mary Hellen, Brito, Maria Aparecida V. Paiva, Fietto, Luciano Gomes, Ribon, Andréa de Oliveira Barros
Published in Veterinary microbiology (09.11.2012)
Published in Veterinary microbiology (09.11.2012)
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Journal Article
The Nothoaspis amazoniensis Complete Mitogenome: A Comparative and Phylogenetic Analysis
Lima, Paulo H C, Vidigal, Pedro M P, Barcelos, Rafael M, Klein, Raphael C, Montandon, Carlos E, Fabres-Klein, Mary H, Dergam, Jorge A, Venzal, José M, Mafra, Cláudio
Published in Veterinary sciences (27.03.2018)
Published in Veterinary sciences (27.03.2018)
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Journal Article
Sequencing and comparative analysis of the Amblyomma sculptum mitogenome
de Lima, Paulo Henrique Costa, Barcelos, Rafael Mazioli, Klein, Raphael Contelli, Vidigal, Pedro Marcus Pereira, Montandon, Carlos Emmanuel, Fabres-Klein, Mary Hellen, Dergam, Jorge Abdala, Mafra, Cláudio
Published in Veterinary parasitology (30.11.2017)
Published in Veterinary parasitology (30.11.2017)
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Journal Article
Strategies to select yeast starters cultures for production of flavor compounds in cachaça fermentations
de Souza, Anderson Proust Gonçalves, Vicente, Maristela de Araújo, Klein, Raphael Contelli, Fietto, Luciano Gomes, Coutrim, Maurício Xavier, de Cássia Franco Afonso, Robson José, Araújo, Leandro Dias, da Silva, Paulo Henrique Alves, Bouillet, Leoneide Érica Maduro, Castro, Ieso Miranda, Brandão, Rogelio Lopes
Published in Antonie van Leeuwenhoek (01.02.2012)
Published in Antonie van Leeuwenhoek (01.02.2012)
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Journal Article
Efeito da incorporação de nanosílica e sílica ativa em argamassas frente ao ataque interno e externo de sulfatos
Schmalz, Rosana, Alves, Raphael Klein, Leoni, Vitor Lourensato, Quarcioni, Valdecir Ângelo, Ferreira, Fernanda Giannotti da Silva
Published in Revista Principia (30.09.2022)
Published in Revista Principia (30.09.2022)
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Journal Article
Maximum Common Substructure Searching in Combinatorial Make-on-Demand Compound Spaces
Schmidt, Robert, Klein, Raphael, Rarey, Matthias
Published in Journal of chemical information and modeling (09.05.2022)
Published in Journal of chemical information and modeling (09.05.2022)
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Journal Article
Overcoming obstacles encountered on the way to commercialize university IP
Klein, Raphael, Haan, Uzi de, Goldberg, Albert I
Published in The Journal of technology transfer (01.12.2010)
Published in The Journal of technology transfer (01.12.2010)
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Journal Article
Relevance of the Trillion-Sized Chemical Space “eXplore” as a Source for Drug Discovery
Neumann, Alexander, Marrison, Lester, Klein, Raphael
Published in ACS medicinal chemistry letters (13.04.2023)
Published in ACS medicinal chemistry letters (13.04.2023)
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Journal Article