Phase I Study of Folate Conjugate EC145 (Vintafolide) in Patients With Refractory Solid Tumors
LORUSSO, Patricia M, EDELMAN, Martin J, LEAMON, Christopher P, MESSMANN, Richard A, SAUSVILLE, Edward A, BEVER, Susan L, FORMAN, Karen M, PILAT, Maryjo, QUINN, Mary F, JING LI, HEATH, Elisabeth I, MALBURG, Lisa M, KLEIN, Patrick J
Published in Journal of clinical oncology (10.11.2012)
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Preclinical Evaluation of Bispecific Adaptor Molecule Controlled Folate Receptor CAR-T Cell Therapy With Special Focus on Pediatric Malignancies
Lu, Yingjuan J, Chu, Haiyan, Wheeler, Leroy W, Nelson, Melissa, Westrick, Elaine, Matthaei, James F, Cardle, Ian I, Johnson, Adam, Gustafson, Joshua, Parker, Nikki, Vetzel, Marilynn, Xu, Le-Cun, Wang, Emilia Z, Jensen, Michael C, Klein, Patrick J, Low, Philip S, Leamon, Christopher P
Published in Frontiers in oncology (19.03.2019)
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Targeting Folate Receptors to Treat Invasive Urinary Bladder Cancer
DHAWAN, Deepika, RAMOS-VARA, Jose A, REDDY, Joseph A, KOCH, Michael, MURPHY, Linda, FOUREZ, Lindsey M, STEWART, Jane C, KNAPP, Deborah W, NAUGHTON, James F, LIANG CHENG, LOW, Philip S, ROTHENBUHLER, Ryan, LEAMON, Christopher P, PARKER, Nikki, KLEIN, Patrick J, VLAHOV, Lontcho R
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Targeting folate receptor beta on monocytes/macrophages renders rapid inflammation resolution independent of root causes
Lu, Yingjuan J., Wheeler, Leroy W., Chu, Haiyan, Kleindl, Paul J., Pugh, Michael, You, Fei, Rao, Satish, Garcia, Gabriela, Wu, Henry Y., da Cunha, Andre P., Johnson, Richard, Westrick, Elaine, Cross, Vicky, Lloyd, Alex, Dircksen, Christina, Klein, Patrick J., Vlahov, Iontcho R., Low, Philip S., Leamon, Christopher P.
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Resistance to Mitogen-Activated Protein Kinase Kinase (MEK) Inhibitors Correlates with Up-Regulation of the MEK/Extracellular Signal-Regulated Kinase Pathway in Hepatocellular Carcinoma Cells
Yip-Schneider, Michele T, Klein, Patrick J, Wentz, Sabrina C, Zeni, Amer, Menze, Alex, Schmidt, C Max
Published in The Journal of pharmacology and experimental therapeutics (01.06.2009)
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Alcohol Induces Liver Neoplasia in a Novel Alcohol-Preferring Rat Model
Yip-Schneider, Michele T., Doyle, Courtney J., McKillop, Iain H., Wentz, Sabrina C., Brandon-Warner, Elizabeth, Matos, Jesus M., Sandrasegaran, Kumaresan, Saxena, Romil, Hennig, Matthew E., Wu, Huangbing, Waters, Joshua A., Klein, Patrick J., Froehlich, Janice C., Max Schmidt, C.
Published in Alcoholism, clinical and experimental research (01.12.2011)
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The Effects of a Novel MEK Inhibitor PD184161 on MEK-ERK Signaling and Growth in Human Liver Cancer
Klein, Patrick J., Schmidt, C. Max, Wiesenauer, Chad A., Choi, Jennifer N., Gage, Earl A., Yip-Schneider, Michele T., Wiebke, Eric A., Wang, Yufang, Omer, Charles, Sebolt-Leopold, Judith S.
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Published in Neoplasia (New York, N.Y.) (01.01.2006)
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Interlaminar fracture toughness of woven fabric composite laminates with carbon nanotube/epoxy interleaf films
Sager, Ryan J., Klein, Patrick J., Davis, Daniel C., Lagoudas, Dimitris C., Warren, Graham L., Sue, Hung-Jue
Published in Journal of applied polymer science (15.08.2011)
Published in Journal of applied polymer science (15.08.2011)
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Enhancing the therapeutic range of a targeted small-molecule tubulysin conjugate for folate receptor-based cancer therapy
Leamon, Christopher P., Reddy, Joseph A., Vlahov, Iontcho R., Dorton, Ryan, Bloomfield, Alicia, Vetzel, Marilynn, Klein, Patrick J., Westrick, Elaine, Xu, Le-cun, Wang, Yu
Published in Cancer chemotherapy and pharmacology (01.06.2017)
Published in Cancer chemotherapy and pharmacology (01.06.2017)
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Clinical pharmacokinetics and exposure-toxicity relationship of a folate-Vinca alkaloid conjugate EC145 in cancer patients
Li, Jing, Sausville, Edward A, Klein, Patrick J, Morgenstern, David, Leamon, Christopher P, Messmann, Richard A, LoRusso, Patricia
Published in Journal of clinical pharmacology (01.12.2009)
Published in Journal of clinical pharmacology (01.12.2009)
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Development and validation of a UPLC–MS/MS method for the novel folate-targeted small molecule drug conjugate EC1456 and its metabolites in tumor homogenates from mice
Rao, Satish I., Pugh, Michael, Nelson, Melissa, Reddy, Joseph A., Klein, Patrick J., Leamon, Christopher P.
Published in Journal of pharmaceutical and biomedical analysis (15.04.2016)
Published in Journal of pharmaceutical and biomedical analysis (15.04.2016)
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Phase I/II clinical trial of the targeted chemotherapeutic drug, folate-tubulysin, in dogs with naturally-occurring invasive urothelial carcinoma
Szigetvari, Nicholas M, Dhawan, Deepika, Ramos-Vara, José A, Leamon, Christopher P, Klein, Patrick J, Ruple, A Audrey, Heng, Hock Gan, Pugh, Michael R, Rao, Satish, Vlahov, Iontcho R, Deshuillers, Pierre L, Low, Philip S, Fourez, Lindsey M, Cournoyer, Ashleigh M, Knapp, Deborah W
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Published in Oncotarget (11.12.2018)
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Mechanism of 1,3-dichloropropene-induced rat liver carcinogenesis
Klaunig, James E, Gehen, Sean C, Wang, Zemin, Klein, Patrick J, Billington, Richard
Published in Toxicological sciences (01.01.2015)
Published in Toxicological sciences (01.01.2015)
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Treatment of experimental adjuvant arthritis with a novel folate receptor-targeted folic acid-aminopterin conjugate
Lu, Yingjuan, Stinnette, Torian W, Westrick, Elaine, Klein, Patrick J, Gehrke, Mark A, Cross, Vicky A, Vlahov, Iontcho R, Low, Philip S, Leamon, Christopher P
Published in Arthritis research & therapy (04.04.2011)
Published in Arthritis research & therapy (04.04.2011)
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Reducing undesirable hepatic clearance of a tumor-targeted vinca alkaloid via novel saccharopeptidic modifications
Leamon, Christopher P, Reddy, Joseph A, Klein, Patrick J, Vlahov, Iontcho R, Dorton, Ryan, Bloomfield, Alicia, Nelson, Melissa, Westrick, Elaine, Parker, Nikki, Bruna, Kristen, Vetzel, Marilynn, Gehrke, Mark, Nicoson, Jeffrey S, Messmann, Richard A, LoRusso, Patricia M, Sausville, Edward A
Published in The Journal of pharmacology and experimental therapeutics (01.02.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2011)
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Antiinflammatory Activity of a Novel Folic Acid Targeted Conjugate of the mTOR Inhibitor Everolimus
Lu, Yingjuan, Parker, Nikki, Kleindl, Paul J, Cross, Vicky A, Wollak, Kristin, Westrick, Elaine, Stinnette, Torian W, Gehrke, Mark A, Wang, Kevin, Santhapuram, Hari Krishna R, You, Fei, Hahn, Spencer J, Vaughn, Jeremy F, Klein, Patrick J, Vlahov, Iontcho R, Low, Philip S, Leamon, Christopher P
Published in Molecular medicine (Cambridge, Mass.) (08.07.2015)
Published in Molecular medicine (Cambridge, Mass.) (08.07.2015)
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Parthenolide Cooperates with NS398 to Inhibit Growth of Human Hepatocellular Carcinoma Cells through Effects on Apoptosis and G0-G1 Cell Cycle Arrest
Ralstin, Matthew C, Gage, Earl A, Yip-Schneider, Michele T, Klein, Patrick J, Wiebke, Eric A, Schmidt, C Max
Published in Molecular cancer research (01.06.2006)
Published in Molecular cancer research (01.06.2006)
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Proteomic Analysis of Neuroblastoma Subtypes in Response to Mitogen-Activated Protein Kinase Inhibition: Profiling Multiple Targets of Cancer Kinase Signaling
Sandoval, John A., Eppstein, Andrew C., Hoelz, Derek J., Klein, Patrick J., Linebarger, Jared H., Turner, Katharyn E., Rescorla, Frederick J., Hickey, Robert J., Malkas, Linda H., Schmidt, Christian M.
Published in The Journal of surgical research (01.07.2006)
Published in The Journal of surgical research (01.07.2006)
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Conference Proceeding
In Vivo Structural Activity and Optimization Studies of Folate−Tubulysin Conjugates
Reddy, Joseph A, Dorton, Ryan, Dawson, Alicia, Vetzel, Marilynn, Parker, Nikki, Nicoson, Jeffrey S, Westrick, Elaine, Klein, Patrick J, Wang, Yu, Vlahov, Iontcho R, Leamon, Christopher P
Published in Molecular pharmaceutics (05.10.2009)
Published in Molecular pharmaceutics (05.10.2009)
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