Potential strategy for assessing QT/QTc interval for drugs that produce rapid changes in heart rate: Electrocardiographic assessment of the effects of intravenous remimazolam on cardiac repolarization
Kleiman, Robert B., Darpo, Borje, Thorn, Michael, Stoehr, Thomas, Schippers, Frank
Published in British journal of clinical pharmacology (01.08.2020)
Published in British journal of clinical pharmacology (01.08.2020)
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Journal Article
Ventricular Arrhythmias Associated With Over-the-Counter and Recreational Opioids
Krantz, Mori J., Rudo, Todd J., Haigney, Mark C.P., Stockbridge, Norman, Kleiman, Robert B., Klein, Michael, Kao, David P.
Published in Journal of the American College of Cardiology (13.06.2023)
Published in Journal of the American College of Cardiology (13.06.2023)
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Journal Article
Evaluation of the Effect of SPN-812 (Viloxazine Extended-Release) on QTc Interval in Healthy Adults
Nasser, Azmi, Faison, Shamia L, Liranso, Tesfaye, Adewole, Toyin, Busse, Gregory D, Fava, Maurizio, Kleiman, Robert B, Schwabe, Stefan
Published in The journal of clinical psychiatry (13.10.2020)
Published in The journal of clinical psychiatry (13.10.2020)
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Journal Article
Improving the in Vivo QTc assay: The value of implementing best practices to support an integrated nonclinical-clinical QTc risk assessment and TQT substitute
Vargas, Hugo M., Rossman, Eric I., Wisialowski, Todd A., Nichols, Jill, Pugsley, Michael K., Roche, Brian, Gintant, Gary A., Greiter-Wilke, Andrea, Kleiman, Robert B., Valentin, Jean-Pierre, Leishman, Derek J.
Published in Journal of pharmacological and toxicological methods (01.05.2023)
Published in Journal of pharmacological and toxicological methods (01.05.2023)
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Journal Article
Intracellular uptake of agents that block the hERG channel can confound the assessment of QT interval prolongation and arrhythmic risk
Burashnikov, Alexander, Barajas-Martinez, Hector, Cox, Robert, Demitrack, Mark A., Fossler, Michael J., Kramer, Michael, Kleiman, Robert B., Kowey, Peter, Antzelevitch, Charles
Published in Heart rhythm (01.12.2021)
Published in Heart rhythm (01.12.2021)
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Journal Article
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As
Rossman, Eric I., Wisialowski, Todd A., Vargas, Hugo M., Valentin, Jean-Pierre, Rolf, Michael G., Roche, Brian M., Riley, Steve, Pugsley, Michael K., Nichols, Jill, Li, Dingzhou, Leishman, Derek J., Kleiman, Robert B., Greiter-Wilke, Andrea, Gintant, Gary A., Engwall, Michael J., Delaunois, Annie, Authier, Simon
Published in Journal of pharmacological and toxicological methods (01.09.2023)
Published in Journal of pharmacological and toxicological methods (01.09.2023)
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Journal Article
Replacing the thorough QT study: reflections of a baby in the bath water
Kleiman, Robert B., Shah, Rashmi R., Morganroth, Joel
Published in British journal of clinical pharmacology (01.08.2014)
Published in British journal of clinical pharmacology (01.08.2014)
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Journal Article
Long-term Electrocardiographic Safety Monitoring in Clinical Drug Development: A Report from the Cardiac Safety Research Consortium
Piccini, Jonathan P, Clark, Richard L, Kowey, Peter R, Mittal, Suneet, Dunmon, Preston, Stockbridge, Norman, Reiffel, James A, Turakhia, Mintu P, Ziegler, Paul D, Kleiman, Robert B, Ismat, Fraz, Sager, Philip
Published in The American heart journal (01.05.2017)
Published in The American heart journal (01.05.2017)
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Journal Article
Thorough QT/QTc Evaluation of the Cardiac Safety of Enarodustat (JTZ‐951), an Oral Erythropoiesis‐Stimulating Agent, in Healthy Adults
Pai, Sudhakar M., Yamada, Hiroyuki, Kleiman, Robert B., Zhuo, Rui, Huang, Qingtao (Mike), Koretomo, Ryosuke
Published in Clinical pharmacology in drug development (01.08.2021)
Published in Clinical pharmacology in drug development (01.08.2021)
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Journal Article
Intracellular Uptake of Agents That Block the hERG Channel Can Confound Assessment of QT Prolongation and Arrhythmic Risk
Burashnikov, Alexander, Barajas-Martinez, Hector, Cox, Robert, Demitrack, Mark A., Fossler, Michael J., Kramer, Michael, Kleiman, Robert B., Kowey, Peter, Antzelevitch, Charles
Published in Heart rhythm (02.09.2021)
Published in Heart rhythm (02.09.2021)
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Journal Article
A Novel Approach to QTc Studies: Assessing Cardiac Safety of the mTOR Kinase Inhibitor CC-223 within the Dose-Escalation/Expansion Study
Kleiman, Robert B, Chopra, Rajesh, Hans, de Haan, Hege, Kristen, James, Angela J, Wang, Xiaomin, Wu, Xiaoling, O'Mara, Edward
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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Journal Article
Acute and chronic cycle length dependent increase in ventricular pacing threshold
Hook, B G, Perlman, R L, Callans, D J, Hanna, M S, Kleiman, R B, Flores, B T, Marchlinski, F E
Published in Pacing and clinical electrophysiology (01.10.1992)
Published in Pacing and clinical electrophysiology (01.10.1992)
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Journal Article
Implantable cardioverter-defibrillator therapy in the absence of significant symptoms : rhythm diagnosis and management aided by stored electrogram analysis
HOOK, B. G, CELLANS, D. J, KLEIMAN, R. B, FLORES, B. T, MARCHLINSKI, F. E
Published in Circulation (New York, N.Y.) (01.06.1993)
Published in Circulation (New York, N.Y.) (01.06.1993)
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Journal Article
Electrophysiologic and mechanical properties of single feline RV and LV myocytes
Kleiman, Robert B., Houser, Steven R.
Published in Journal of molecular and cellular cardiology (01.11.1988)
Published in Journal of molecular and cellular cardiology (01.11.1988)
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Journal Article