NOX toolbox: validating the role of NADPH oxidases in physiology and disease
Altenhöfer, Sebastian, Kleikers, Pamela W. M, Radermacher, Kim A, Scheurer, Peter, Rob Hermans, J. J, Schiffers, Paul, Ho, Heidi, Wingler, Kirstin, Schmidt, Harald H. H. W
Published in Cellular and molecular life sciences : CMLS (01.07.2012)
Published in Cellular and molecular life sciences : CMLS (01.07.2012)
Get full text
Journal Article
NADPH oxidases as a source of oxidative stress and molecular target in ischemia/reperfusion injury
Kleikers, Pamela W. M., Wingler, K., Hermans, J. J. R., Diebold, I., Altenhöfer, S., Radermacher, K. A., Janssen, B., Görlach, A., Schmidt, H. H. H. W.
Published in Journal of molecular medicine (Berlin, Germany) (01.12.2012)
Published in Journal of molecular medicine (Berlin, Germany) (01.12.2012)
Get full text
Journal Article
Endothelial reactive oxygen-forming NADPH oxidase 5 is a possible player in diabetic aortic aneurysm but not atherosclerosis
Ho, Florence, Watson, Anna M. D., Elbatreek, Mahmoud H., Kleikers, Pamela W. M., Khan, Waheed, Sourris, Karly C., Dai, Aozhi, Jha, Jay, Schmidt, Harald H. H. W., Jandeleit-Dahm, Karin A. M.
Published in Scientific reports (07.07.2022)
Published in Scientific reports (07.07.2022)
Get full text
Journal Article
From single drug targets to synergistic network pharmacology in ischemic stroke
Casas, Ana I., Hassan, Ahmed A., Larsen, Simon J., Gomez-Rangel, Vanessa, Elbatreek, Mahmoud, Kleikers, Pamela W. M., Guney, Emre, Egea, Javier, López, Manuela G., Baumbach, Jan, Schmidt, Harald H. H. W.
Published in Proceedings of the National Academy of Sciences - PNAS (02.04.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (02.04.2019)
Get full text
Journal Article
NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage
Casas, Ana I., Geuss, Eva, Kleikers, Pamela W. M., Mencl, Stine, Herrmann, Alexander M., Buendia, Izaskun, Egea, Javier, Meuth, Sven G., Lopez, Manuela G., Kleinschnitz, Christoph, Schmidt, Harald H. H. W.
Published in Proceedings of the National Academy of Sciences - PNAS (14.11.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (14.11.2017)
Get full text
Journal Article
NOX5-induced uncoupling of endothelial NO synthase is a causal mechanism and theragnostic target of an age-related hypertension endotype
Elbatreek, Mahmoud H, Sadegh, Sepideh, Anastasi, Elisa, Guney, Emre, Nogales, Cristian, Kacprowski, Tim, Hassan, Ahmed A, Teubner, Andreas, Huang, Po-Hsun, Hsu, Chien-Yi, Schiffers, Paul M H, Janssen, Ger M, Kleikers, Pamela W M, Wipat, Anil, Baumbach, Jan, De Mey, Jo G R, Schmidt, Harald H H W
Published in PLoS biology (01.11.2020)
Published in PLoS biology (01.11.2020)
Get full text
Journal Article
A combined pre-clinical meta-analysis and randomized confirmatory trial approach to improve data validity for therapeutic target validation
Kleikers, Pamela WM, Hooijmans, Carlijn, Göb, Eva, Langhauser, Friederike, Rewell, Sarah SJ, Radermacher, Kim, Ritskes-Hoitinga, Merel, Howells, David W., Kleinschnitz, Christoph, HHW Schmidt, Harald
Published in Scientific reports (27.08.2015)
Published in Scientific reports (27.08.2015)
Get full text
Journal Article
NOS knockout or inhibition but not disrupting PSD-95-NOS interaction protect against ischemic brain damage
Kleinschnitz, Christoph, Mencl, Stine, Kleikers, Pamela WM, Schuhmann, Michael K, G López, Manuela, Casas, Ana I, Sürün, Bilge, Reif, Andreas, Schmidt, Harald HHW
Published in Journal of cerebral blood flow and metabolism (01.09.2016)
Published in Journal of cerebral blood flow and metabolism (01.09.2016)
Get full text
Journal Article
Calcium-dependent blood-brain barrier breakdown by NOX5 limits postreperfusion benefit in stroke
Casas, Ana I, Kleikers, Pamela Wm, Geuss, Eva, Langhauser, Friederike, Adler, Thure, Busch, Dirk H, Gailus-Durner, Valerie, de Angelis, Martin Hrabê, Egea, Javier, Lopez, Manuela G, Kleinschnitz, Christoph, Schmidt, Harald Hhw
Published in The Journal of clinical investigation (01.04.2019)
Published in The Journal of clinical investigation (01.04.2019)
Get full text
Journal Article
A diseasome cluster-based drug repurposing of soluble guanylate cyclase activators from smooth muscle relaxation to direct neuroprotection
Langhauser, Friederike, Casas, Ana I., Dao, Vu-Thao-Vi, Guney, Emre, Menche, Jörg, Geuss, Eva, Kleikers, Pamela W. M., López, Manuela G., Barabási, Albert-L., Kleinschnitz, Christoph, Schmidt, Harald H. H. W.
Published in NPJ systems biology and applications (05.02.2018)
Published in NPJ systems biology and applications (05.02.2018)
Get full text
Journal Article
PP71 - NOX, NOS and sGC as new therapeutic targets in stroke
Casas, Ana I, Langhauser, Friederike, Mencl, S., Egea, Javier, Dao, Vu Thao-Vi, Kleikers, Pamela WM, García López, Manuela, Kleinschnitz, Christoph, HHW Schmidt, Harald
Published in Free radical biology & medicine (01.09.2015)
Published in Free radical biology & medicine (01.09.2015)
Get full text
Journal Article
NOX, NOS and sGC as new therapeutic targets in stroke
Casas, Ana I, Langhauser, Friederike, Mencl, S., Egea, Javier, Dao, Vu Thao-Vi, Kleikers, Pamela WM, García López, Manuela, Kleinschnitz, Christoph, HHW Schmidt, Harald
Published in Free radical biology & medicine (01.09.2015)
Published in Free radical biology & medicine (01.09.2015)
Get full text
Journal Article
A systems biology approach to cGMP suggests a prominent role for sGC in stroke: Validation by mechanism-based activation of apo-sGC in non-steal dosing coveys neuroprotection and increased survival
Casas, Ana I, Langhauser, Friederike, Dao, Vu Thao-Vi, Guney, Emre, Kleikers, Pamela WM, López, Manuela García, Menche, Jörg, Barabási, Albert-László, Kleinschnitz, Christoph, Schmidt, Harald HHW
Published in BMC pharmacology & toxicology (02.09.2015)
Published in BMC pharmacology & toxicology (02.09.2015)
Get full text
Journal Article
A premature with nail defects
van der Sluijs-Bens, Jacqueline P F, Kleikers, Pamela W M
Published in Nederlands tijdschrift voor geneeskunde (2010)
Get more information
Published in Nederlands tijdschrift voor geneeskunde (2010)
Journal Article