Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion
Tervonen, T A, Belitškin, D, Pant, S M, Englund, J I, Marques, E, Ala-Hongisto, H, Nevalaita, L, Sihto, H, Heikkilä, P, Leidenius, M, Hewitson, K, Ramachandra, M, Moilanen, A, Joensuu, H, Kovanen, P E, Poso, A, Klefström, J
Published in Oncogene (07.04.2016)
Published in Oncogene (07.04.2016)
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Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers
Marques, E, Englund, J I, Tervonen, T A, Virkunen, E, Laakso, M, Myllynen, M, Mäkelä, A, Ahvenainen, M, Lepikhova, T, Monni, O, Hautaniemi, S, Klefström, J
Published in Oncogene (17.03.2016)
Published in Oncogene (17.03.2016)
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Liprin‐α1 contributes to oncogenic MAPK signaling by counteracting ERK activity
Pehkonen, Henna, Filippou, Artemis, Väänänen, Juho, Lindfors, Iida, Vänttinen, Mira, Ianevski, Philipp, Mäkelä, Anne, Munne, Pauliina, Klefström, Juha, Toppila‐Salmi, Sanna, Grénman, Reidar, Hagström, Jaana, Mäkitie, Antti A., Karhemo, Piia‐Riitta, Monni, Outi
Published in Molecular oncology (01.03.2024)
Published in Molecular oncology (01.03.2024)
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ANO1 Expression Orchestrates p27Kip1/MCL1-Mediated Signaling in Head and Neck Squamous Cell Carcinoma
Filippou, Artemis, Pehkonen, Henna, Karhemo, Piia-Riitta, Väänänen, Juho, Nieminen, Anni I, Klefström, Juha, Grénman, Reidar, Mäkitie, Antti A, Joensuu, Heikki, Monni, Outi
Published in Cancers (09.03.2021)
Published in Cancers (09.03.2021)
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173 Ras-mediated activation of mitogen-activated protein kinase pathway unleashes basement membrane damaging activity of serine protease hepsin
Tervonen, T, Pant, S, Belitskin, D, Englund, J, Närhi, K, Verschuren, E, Kovanen, P, Klefström, J
Published in European journal of cancer (1990) (01.11.2014)
Published in European journal of cancer (1990) (01.11.2014)
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380 Functional Properties of PPFIA1, Located at the 11q13 Amplification Region, in Epithelial Cancer Cells
Pehkonen, H, Lepikhova, T, Louhimo, R, Peitsaro, N, Imai, M, Martinez, R, Klefström, J, Hautaniemi, S, Monni, O
Published in European journal of cancer (1990) (01.07.2012)
Published in European journal of cancer (1990) (01.07.2012)
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Hepsin promotes breast tumor growth signaling via TGF beta-EGFR axis
Tervonen, T., Belitskin, D., Munne, P., Pant, S., Anttila, J., Belitskina, K., Pouwels, J., Klefström, J.
Published in European journal of cancer (1990) (01.10.2022)
Published in European journal of cancer (1990) (01.10.2022)
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Patient-Derived Explant Cultures (PDECs) as a Model System for Immuno-Oncology Studies
Turpin, R., Munne, P.M., Suleymanova, I., Mustjoki, S., Pouwels, J., Klefström, J.
Published in Annals of oncology (01.12.2019)
Published in Annals of oncology (01.12.2019)
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c‐Myc induces cellular susceptibility to the cytotoxic action of TNF‐alpha
Klefstrom, J., Västrik, I., Saksela, E., Valle, J., Eilers, M., Alitalo, K.
Published in The EMBO journal (15.11.1994)
Published in The EMBO journal (15.11.1994)
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Two novel human B-cell lymphoma lines of lymphatic follicle origin: cytogenetic, molecular genetic and histopathological characterisation
Knuutila, S, Klefström, J, Szymanska, J, Lakkala, T, Peltomäki, P, Eray, M, Teerenhovi, L, Elonen, E, Franssila, K O, Kaartinen, M
Published in European journal of haematology (01.02.1994)
Published in European journal of haematology (01.02.1994)
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Laminin matrix adhesion regulates basal mammary epithelial cell identity
Englund, Johanna I, Bui, Hien, Dinç, Defne D, Paavolainen, Oona, McKenna, Tomás, Laitinen, Suvi, Munne, Pauliina, Klefström, Juha, Peuhu, Emilia, Katajisto, Pekka
Published in Journal of cell science (01.12.2022)
Published in Journal of cell science (01.12.2022)
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The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo
Verschuren, Emmy W., Klefstrom, Juha, Evan, Gerard I., Jones, Nic
Published in Cancer cell (01.09.2002)
Published in Cancer cell (01.09.2002)
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Myc protein: partners and antagonists
Västrik, I, Mäkelä, T P, Koskinen, P J, Klefstrom, J, Alitalo, K
Published in Critical reviews in oncogenesis (1994)
Published in Critical reviews in oncogenesis (1994)
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Comparison of VEGF, VEGF-B, VEGF-C and ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia
ENHOLM, B, PAAVONEN, K, ERIKSSON, U, ALITALO, K, RISTIMÄKI, A, KUMAR, V, GUNJI, Y, KLEFSTROM, J, KIVINEN, L, LAIHO, M, OLOFSSON, B, JOUKOV, V
Published in Oncogene (22.05.1997)
Published in Oncogene (22.05.1997)
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BCL2 Overexpression Associated With Chromosomal Amplification in Diffuse Large B-Cell Lymphoma
Monni, Outi, Joensuu, Heikki, Franssila, Kaarle, Klefstrom, Juha, Alitalo, Kari, Knuutila, Sakari
Published in Blood (01.08.1997)
Published in Blood (01.08.1997)
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Induction of TNF-sensitive cellular phenotype by c-Myc involves p53 and impaired NF-kappaB activation
Klefstrom, J, Arighi, E, Littlewood, T, Jäättelä, M, Saksela, E, Evan, G I, Alitalo, K
Published in The EMBO journal (15.12.1997)
Published in The EMBO journal (15.12.1997)
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c-Myc and E1A induced cellular sensitivity to activated NK cells involves cytotoxic granules as death effectors
KLEFSTROM, J, KOVANEN, P. E, SOMERSALO, K, HUEBER, A.-O, LITTLEWOOD, T, EVAN, G. I, GREENBERG, A. H, SAKSELA, E, TIMONEN, T, ALITALO, K
Published in Oncogene (01.04.1999)
Published in Oncogene (01.04.1999)
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BCL2 overexpression associated with chromosomal amplification in diffuse large B-cell lymphoma
MONNI, O, JOENSUU, H, FRANSSILA, K, KLEFSTROM, J, ALITALO, K, KNUUTILA, S
Published in Blood (01.08.1997)
Published in Blood (01.08.1997)
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