In Vivo Silencing of the Transcription Factor IRF5 Reprograms the Macrophage Phenotype and Improves Infarct Healing
Courties, Gabriel, PhD, Heidt, Timo, MD, Sebas, Matthew, BS, Iwamoto, Yoshiko, BS, Jeon, Derrick, MS, Truelove, Jessica, BS, Tricot, Benoit, MS, Wojtkiewicz, Greg, MS, Dutta, Partha, PhD, Sager, Hendrik B., MD, Borodovsky, Anna, PhD, Novobrantseva, Tatiana, PhD, Klebanov, Boris, PhD, Fitzgerald, Kevin, PhD, Anderson, Daniel G., PhD, Libby, Peter, MD, Swirski, Filip K., PhD, Weissleder, Ralph, MD, PhD, Nahrendorf, Matthias, MD, PhD
Published in Journal of the American College of Cardiology (22.04.2014)
Published in Journal of the American College of Cardiology (22.04.2014)
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Journal Article
Antibodies Targeting Human or Mouse VSIG4 Repolarize Tumor-Associated Macrophages Providing the Potential of Potent and Specific Clinical Anti-Tumor Response Induced across Multiple Cancer Types
Sazinsky, Stephen, Zafari, Mohammad, Klebanov, Boris, Ritter, Jessica, Nguyen, Phuong A, Phennicie, Ryan T, Wahle, Joe, Kauffman, Kevin J, Razlog, Maja, Manfra, Denise, Feldman, Igor, Novobrantseva, Tatiana
Published in International journal of molecular sciences (01.06.2024)
Published in International journal of molecular sciences (01.06.2024)
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Journal Article
Selinexor-induced thrombocytopenia results from inhibition of thrombopoietin signaling in early megakaryopoiesis
Machlus, Kellie R., Wu, Stephen K., Vijey, Prakrith, Soussou, Thomas S., Liu, Zhi-Jian, Shacham, Eran, Unger, T.J., Kashyap, Trinayan, Klebanov, Boris, Sola-Visner, Martha, Crochiere, Marsha, Italiano, Joseph E., Landesman, Yosef
Published in Blood (31.08.2017)
Published in Blood (31.08.2017)
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Journal Article
Influence of Cationic Lipid Composition on Gene Silencing Properties of Lipid Nanoparticle Formulations of siRNA in Antigen-Presenting Cells
Basha, Genc, Novobrantseva, Tatiana I, Rosin, Nicole, Tam, Yuen Yi C, Hafez, Ismail M, Wong, Matthew K, Sugo, Tsukasa, Ruda, Vera M, Qin, June, Klebanov, Boris, Ciufolini, Marco, Akinc, Akin, Tam, Ying K, Hope, Michael J, Cullis, Pieter R
Published in Molecular therapy (01.12.2011)
Published in Molecular therapy (01.12.2011)
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Journal Article
Clinical Dosing Regimen of Selinexor Maintains Normal Immune Homeostasis and T-cell Effector Function in Mice: Implications for Combination with Immunotherapy
Tyler, Paul M, Servos, Mariah M, de Vries, Romy C, Klebanov, Boris, Kashyap, Trinayan, Sacham, Sharon, Landesman, Yosef, Dougan, Michael, Dougan, Stephanie K
Published in Molecular cancer therapeutics (01.03.2017)
Published in Molecular cancer therapeutics (01.03.2017)
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Journal Article
The Exportin-1 Inhibitor Selinexor Exerts Superior Antitumor Activity when Combined with T-Cell Checkpoint Inhibitors
Farren, Matthew R, Hennessey, Rebecca C, Shakya, Reena, Elnaggar, Omar, Young, Gregory, Kendra, Kari, Landesman, Yosef, Elloul, Sivan, Crochiere, Marsha, Klebanov, Boris, Kashyap, Trinayan, Burd, Christin E, Lesinski, Gregory B
Published in Molecular cancer therapeutics (01.03.2017)
Published in Molecular cancer therapeutics (01.03.2017)
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Journal Article
Differential expression of CCR8 in tumors versus normal tissue allows specific depletion of tumor-infiltrating T regulatory cells by GS-1811, a novel Fc-optimized anti-CCR8 antibody
Weaver, Jessica D., Stack, Edward C., Buggé, Joshua A., Hu, Changyun, McGrath, Lara, Mueller, Amy, Wong, Masie, Klebanov, Boris, Rahman, Tanzila, Kaufman, Rosemary, Fregeau, Christine, Spaulding, Vikki, Priess, Michelle, Legendre, Kristen, Jaffe, Sarah, Upadhyay, Dhruvkumar, Singh, Anirudh, Xu, Chang-Ai, Krukenberg, Kristin, Zhang, Yan, Ezzyat, Yassine, Saddier Axe, Dorothée, Kuhne, Michelle R., Meehl, Michael A., Shaffer, Donald R., Weist, Brian M., Wiederschain, Dmitri, Depis, Fabien, Gostissa, Monica
Published in Oncoimmunology (31.12.2022)
Published in Oncoimmunology (31.12.2022)
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Journal Article
Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells
Novobrantseva, Tatiana I, Borodovsky, Anna, Wong, Jamie, Klebanov, Boris, Zafari, Mohammad, Yucius, Kristina, Querbes, William, Ge, Pei, Ruda, Vera M, Milstein, Stuart, Speciner, Lauren, Duncan, Rick, Barros, Scott, Basha, Genc, Cullis, Pieter, Akinc, Akin, Donahoe, Jessica S, Narayanannair Jayaprakash, K, Jayaraman, Muthusamy, Bogorad, Roman L, Love, Kevin, Whitehead, Katie, Levins, Chris, Manoharan, Muthiah, Swirski, Filip K, Weissleder, Ralph, Langer, Robert, Anderson, Daniel G, de Fougerolles, Antonin, Nahrendorf, Matthias, Koteliansky, Victor
Published in Molecular therapy. Nucleic acids (01.01.2012)
Published in Molecular therapy. Nucleic acids (01.01.2012)
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Journal Article
886 Targeting VSIG4, a novel macrophage checkpoint, repolarizes suppressive macrophages which induces an inflammatory response in primary cell in vitro assays and fresh human tumor cultures
Sazinsky, Steve, Nguyen, Phuong, Zafari, Mohammad, Phennicie, Ryan, Wahle, Joe, Komoroski, Veronica, Rooney, Kathryn, Mizzoni, Craig, Klebanov, Boris, Manfra, Denise, Ritter, Jessica, Feldman, Igor, Novobrantseva, Tatiana
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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Journal Article
Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity
Whitehead, Kathryn A., Dorkin, J. Robert, Vegas, Arturo J., Chang, Philip H., Veiseh, Omid, Matthews, Jonathan, Fenton, Owen S., Zhang, Yunlong, Olejnik, Karsten T., Yesilyurt, Volkan, Chen, Delai, Barros, Scott, Klebanov, Boris, Novobrantseva, Tatiana, Langer, Robert, Anderson, Daniel G.
Published in Nature communications (27.06.2014)
Published in Nature communications (27.06.2014)
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Journal Article
A phase 1 clinical trial of single-agent selinexor in acute myeloid leukemia
Garzon, Ramiro, Savona, Michael, Baz, Rachid, Andreeff, Michael, Gabrail, Nashat, Gutierrez, Martin, Savoie, Lynn, Mau-Sorensen, Paul Morten, Wagner-Johnston, Nina, Yee, Karen, Unger, Thaddeus J., Saint-Martin, Jean-Richard, Carlson, Robert, Rashal, Tami, Kashyap, Trinayan, Klebanov, Boris, Shacham, Sharon, Kauffman, Michael, Stone, Richard
Published in Blood (15.06.2017)
Published in Blood (15.06.2017)
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Journal Article
Selinexor, a Selective Inhibitor of Nuclear Export (SINE) compound, acts through NF-κB deactivation and combines with proteasome inhibitors to synergistically induce tumor cell death
Kashyap, Trinayan, Argueta, Christian, Aboukameel, Amro, Unger, Thaddeus John, Klebanov, Boris, Mohammad, Ramzi M, Muqbil, Irfana, Azmi, Asfar S, Drolen, Claire, Senapedis, William, Lee, Margaret, Kauffman, Michael, Shacham, Sharon, Landesman, Yosef
Published in Oncotarget (29.11.2016)
Published in Oncotarget (29.11.2016)
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Journal Article
Abstract P105: Targeting VSIG4, a novel macrophage checkpoint, repolarizes suppressive macrophages which induces an inflammatory response in primary cell in vitro assays and fresh human tumor cultures
Sazinsky, Steve, Nguyen, Ani, Zafari, Mohammad, Phennicie, Ryan, Wahle, Joe, Komoroski, Veronica, Rooney, Kathryn, Mizzoni, Craig, Klebanov, Boris, Ritter, Jessica, Manfra, Denise, Feldman, Igor, Novobrantseva, Tatiana
Published in Molecular cancer therapeutics (01.12.2021)
Published in Molecular cancer therapeutics (01.12.2021)
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Journal Article
Cutting Edge: Hypoxia-Inducible Factor 1α and Its Activation-Inducible Short Isoform I.1 Negatively Regulate Functions of CD4+ and CD8+ T Lymphocytes
Lukashev, Dmitriy, Klebanov, Boris, Kojima, Hidefumi, Grinberg, Alex, Ohta, Akiko, Berenfeld, Ludmilla, Wenger, Roland H., Ohta, Akio, Sitkovsky, Michail
Published in The Journal of immunology (1950) (15.10.2006)
Published in The Journal of immunology (1950) (15.10.2006)
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Journal Article
The principles of multi-agent models of development based on the needs of the agents
Klebanov, Boris, Antropov, Timofey, Riabkina, Ekaterina
Published in 2016 35th Chinese Control Conference (CCC) (01.07.2016)
Published in 2016 35th Chinese Control Conference (CCC) (01.07.2016)
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Conference Proceeding
Journal Article
Selinexor, a Selective Inhibitor of Nuclear Export (SINE) Compound, Shows Synergistic Anti-Tumor Activity in Combination with Dexamethasone Characterized By Specific Pattern of Gene Expression in Multiple Myeloma (MM)
Kashyap, Trinayan, Klebanov, Boris, Lee, Margaret S., Landesman, Yosef
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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Journal Article
Selinexor synergizes with dexamethasone to repress mTORC1 signaling and induce multiple myeloma cell death
Argueta, Christian, Kashyap, Trinayan, Klebanov, Boris, Unger, Thaddeus J, Guo, Cathy, Harrington, Susie, Baloglu, Erkan, Lee, Margaret, Senapedis, William, Shacham, Sharon, Landesman, Yosef
Published in Oncotarget (22.05.2018)
Published in Oncotarget (22.05.2018)
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Journal Article
Selinexor reduces the expression of DNA damage repair proteins and sensitizes cancer cells to DNA damaging agents
Kashyap, Trinayan, Argueta, Christian, Unger, Thaddeus, Klebanov, Boris, Debler, Sophia, Senapedis, William, Crochiere, Marsha L, Lee, Margaret S, Kauffman, Michael, Shacham, Sharon, Landesman, Yosef
Published in Oncotarget (20.07.2018)
Published in Oncotarget (20.07.2018)
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Journal Article