Absorption, distribution, metabolism and excretion of novel phosphodiesterase type 4 inhibitor ASP3258 in rats
Ohtsu, Yoshiaki, Sonoda, Takuya, Susaki, Yoko, Tohda, Toshifumi, Fukunaga, Yasuhisa, Iwatsubo, Takafumi, Noguchi, Kiyoshi
Published in Biopharmaceutics & drug disposition (01.01.2015)
Published in Biopharmaceutics & drug disposition (01.01.2015)
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Elucidation of the Effects of the CYP1A2 Deficiency Polymorphism in the Metabolism of 4-Cyclohexyl-1-ethyl-7-methylpyrido[2,3-d]pyrimidine-2-(1H)-one (YM-64227), a Phosphodiesterase Type 4 Inhibitor, and Its Metabolites in Dogs
TENMIZU, Daisuke, NOGUCHI, Kiyoshi, KAMIMURA, Hidetaka
Published in Drug metabolism and disposition (01.11.2006)
Published in Drug metabolism and disposition (01.11.2006)
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Identification of Human Metabolites of (â)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a Novel If Channel Inhibitor, and Investigation of the Transporter-Mediated Renal and Hepatic Excretion of These Metabolites
Umehara, Ken-ichi, Shirai, Nobuaki, Iwatsubo, Takafumi, Noguchi, Kiyoshi, Usui, Takashi, Kamimura, Hidetaka
Published in Drug metabolism and disposition (01.08.2009)
Published in Drug metabolism and disposition (01.08.2009)
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A study of pole material properties for pole erasure suppression in perpendicular recording heads
Hirata, Kei, Roppongi, Tetsuya, Noguchi, Kiyoshi
Published in Journal of magnetism and magnetic materials (01.02.2005)
Published in Journal of magnetism and magnetic materials (01.02.2005)
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Conference Proceeding
THE CANINE CYP1A2 DEFICIENCY POLYMORPHISM DRAMATICALLY AFFECTS THE PHARMACOKINETICS OF 4-CYCLOHEXYL-1-ETHYL-7-METHYLPYRIDO[2,3-D]-PYRIMIDINE-2-(1H)-ONE (YM-64227), A PHOSPHODIESTERASE TYPE 4 INHIBITOR
TENMIZU, Daisuke, NOGUCHI, Kiyoshi, KAMIMURA, Hidetaka, OHTANI, Hisakazu, SAWADA, Yasufumi
Published in Drug metabolism and disposition (01.05.2006)
Published in Drug metabolism and disposition (01.05.2006)
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Room-Temperature Electron Spin Transport in a Highly Doped Si Channel
Suzuki, Toshio, Sasaki, Tomoyuki, Oikawa, Tohru, Shiraishi, Masashi, Suzuki, Yoshishige, Noguchi, Kiyoshi
Published in Applied physics express (01.02.2011)
Published in Applied physics express (01.02.2011)
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Regulated bioanalysis of conformers – A case study with ASP2151 in dog plasma and urine
Ohtsu, Yoshiaki, Otsuka, Shohei, Nakamura, Takeshi, Noguchi, Kiyoshi
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.08.2015)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.08.2015)
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Evidence of Electrical Spin Injection Into Silicon Using MgO Tunnel Barrier
Sasaki, Tomoyuki, Oikawa, Tohru, Suzuki, Toshio, Shiraishi, Masashi, Suzuki, Yoshishige, Noguchi, Kiyoshi
Published in IEEE transactions on magnetics (01.06.2010)
Published in IEEE transactions on magnetics (01.06.2010)
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Conference Proceeding
Quantification of ASP2151 in Human Plasma and Urine: A Pitfall Associated with Supersaturation of Analyte in Urine
Ohtsu, Yoshiaki, van Trigt, Radboud, Takama, Kaori, Groenendaal, Dorien, Takada, Akitsugu, Nakamura, Takeshi, Noguchi, Kiyoshi
Published in Chromatographia (01.02.2017)
Published in Chromatographia (01.02.2017)
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Determination of ASP3258, a novel phosphodiesterase type 4 inhibitor, in rat plasma by high-performance liquid chromatography with fluorescence detection and its application to pharmacokinetic study
Ohtsu, Yoshiaki, Takanuki, Fumiyo, Fukunaga, Yasuhisa, Noguchi, Kiyoshi
Published in Biomedical chromatography (01.02.2015)
Published in Biomedical chromatography (01.02.2015)
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CPP-GMR Film With ZnO-Based Novel Spacer for Future High-Density Magnetic Recording
Shimazawa, Koji, Noguchi, Kiyoshi, Tsuchiya, Yoshihiro, Mizuno, Tomohito, Hara, Shinji, Chou, Tsutom, Miyauchi, Disuke, Machita, Takahiko, Ayukawa, Toshiyuki, Ichiki, Tsuyoshi
Published in IEEE transactions on magnetics (01.06.2010)
Published in IEEE transactions on magnetics (01.06.2010)
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Conference Proceeding
Relationship between Exposure of (―)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a Funny If Current Channel Inhibitor, and Heart Rate Reduction in Tachycardia-Induced Beagle Dogs
UMEHARA, Ken-Ichi, WADA, Kouichi, NOGUCHI, Kiyoshi, IWATSUBO, Takafumi, USUI, Takashi, KAMIMURA, Hidetaka
Published in Drug metabolism and disposition (01.07.2009)
Published in Drug metabolism and disposition (01.07.2009)
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Investigation of Long-Term Retention of Unchanged (―)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide, A Novel Funny If Current Channel Inhibitor, and Its Metabolites in the Eyeball and Thoracic Aorta of Rats
UMEHARA, Ken-Ichi, NAKADA, Naoyuki, NOGUCHI, Kiyoshi, IWATSUBO, Takafumi, USUI, Takashi, KAMIMURA, Hidetaka
Published in Drug metabolism and disposition (01.11.2009)
Published in Drug metabolism and disposition (01.11.2009)
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Journal Article
Investigation of Long-Term Retention of Unchanged (â)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide, A Novel âFunnyâ If Current Channel Inhibitor, and Its Metabolites in the Eyeball and Thoracic Aorta of Rats
Ken-ichi Umehara, Naoyuki Nakada, Kiyoshi Noguchi, Takafumi Iwatsubo, Takashi Usui, Hidetaka Kamimura
Published in Drug metabolism and disposition (01.11.2009)
Published in Drug metabolism and disposition (01.11.2009)
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Journal Article
Relationship between Exposure of (â)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a âFunnyâ If Current Channel Inhibitor, and Heart Rate Reduction in Tachycardia-Induced Beagle Dogs
Ken-ichi Umehara, Kouichi Wada, Kiyoshi Noguchi, Takafumi Iwatsubo, Takashi Usui, Hidetaka Kamimura
Published in Drug metabolism and disposition (01.07.2009)
Published in Drug metabolism and disposition (01.07.2009)
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Journal Article
Identification of Human Metabolites of (-)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisopuinoline-2-carbonyl)piperidino]ethyl-4-fluorobenzamide (YM758), a Novel If Channel Inhibitor, and Investigation of the Transporter-Mediated Renal and Hepatic Excretion of These Metabolites
UMEHARA, Ken-Ichi, SHIRAI, Nobuaki, LWATSUBO, Takafumi, NOGUCHI, Kiyoshi, USUI, Takashi, KAMIMURA, Hidetaka
Published in Drug metabolism and disposition (2009)
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Published in Drug metabolism and disposition (2009)
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Functional Characterization of Single Nucleotide Polymorphisms with Amino Acid Substitution in CYP1A2, CYP2A6, and CYP2B6 Found in the Japanese Population
Masahiko IWASAKI, Yoshinobu YOSHIMURA, Satoru ASAHI, Kimitoshi SAITO, Shuichi SAKAI, Shigemichi MORITA, Osamu TAKENAKA, Toshio INODA, Eiji KASHIYAMA, Akinori AOYAMA, Takeshi NAKABAYASHI, Satoshi OMORI, Takashi KUWABARA, Takashi IZUMI, Kouichi NAKAMURA, Kaoru TAKANAKA, Yukiharu NAKAYAMA, Mitsuaki TAKEUCHI, Hideki NAKAMURA, Shunichi KAMETANI, Yoshiaki TERAUCHI, Takanori HASHIZUME, Sekio NAGAYAMA, Toshiyuki KUME, Meguru ACHIRA, Hiroyuki KAWAI, Takashi KAWASHIRO, Akio NAKAMURA, Yasuhiro NAKAI, Akira KAGAYAMA, Toshifumi SHIRAGA, Takuro NIWA, Takuya YOSHIMURA, Jun MORITA, Fukuichi OHSAWA, Masato TANI, Nobuo OSAWA, Keiichi IDA, Kiyoshi NOGUCHI
Published in DRUG METABOLISM AND PHARMACOKINETICS (2004)
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Published in DRUG METABOLISM AND PHARMACOKINETICS (2004)
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