Hypoxia-Inducible Factor Prolyl 4-Hydroxylase-2 Inhibition Protects Against Development of Atherosclerosis
Rahtu-Korpela, Lea, Määttä, Jenni, Dimova, Elitsa Y, Hörkkö, Sohvi, Gylling, Helena, Walkinshaw, Gail, Hakkola, Jukka, Kivirikko, Kari I, Myllyharju, Johanna, Serpi, Raisa, Koivunen, Peppi
Published in Arteriosclerosis, thrombosis, and vascular biology (01.04.2016)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.04.2016)
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HIF prolyl 4-hydroxylase-2 inhibition improves glucose and lipid metabolism and protects against obesity and metabolic dysfunction
Rahtu-Korpela, Lea, Karsikas, Sara, Hörkkö, Sohvi, Blanco Sequeiros, Roberto, Lammentausta, Eveliina, Mäkelä, Kari A, Herzig, Karl-Heinz, Walkinshaw, Gail, Kivirikko, Kari I, Myllyharju, Johanna, Serpi, Raisa, Koivunen, Peppi
Published in Diabetes (New York, N.Y.) (01.10.2014)
Published in Diabetes (New York, N.Y.) (01.10.2014)
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Catalytic Properties of the Asparaginyl Hydroxylase (FIH) in the Oxygen Sensing Pathway Are Distinct from Those of Its Prolyl 4-Hydroxylases
Koivunen, Peppi, Hirsilä, Maija, Günzler, Volkmar, Kivirikko, Kari I., Myllyharju, Johanna
Published in The Journal of biological chemistry (12.03.2004)
Published in The Journal of biological chemistry (12.03.2004)
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Hearts of Hypoxia-inducible Factor Prolyl 4-Hydroxylase-2 Hypomorphic Mice Show Protection against Acute Ischemia-Reperfusion Injury
Hyvärinen, Jaana, Hassinen, Ilmo E., Sormunen, Raija, Mäki, Joni M., Kivirikko, Kari I., Koivunen, Peppi, Myllyharju, Johanna
Published in The Journal of biological chemistry (30.04.2010)
Published in The Journal of biological chemistry (30.04.2010)
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Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis
Laitala, Anu, Aro, Ellinoora, Walkinshaw, Gail, Mäki, Joni M., Rossi, Maarit, Heikkilä, Minna, Savolainen, Eeva-Riitta, Arend, Michael, Kivirikko, Kari I., Koivunen, Peppi, Myllyharju, Johanna
Published in Blood (18.10.2012)
Published in Blood (18.10.2012)
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Activation of Hypoxia Response in Endothelial Cells Contributes to Ischemic Cardioprotection
Kerkelä, Risto, Karsikas, Sara, Szabo, Zoltan, Serpi, Raisa, Magga, Johanna, Gao, Erhe, Alitalo, Kari, Anisimov, Andrey, Sormunen, Raija, Pietilä, Ilkka, Vainio, Laura, Koch, Walter J., Kivirikko, Kari I., Myllyharju, Johanna, Koivunen, Peppi
Published in Molecular and Cellular Biology (01.08.2013)
Published in Molecular and Cellular Biology (01.08.2013)
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Lack of P4H-TM in mice results in age-related retinal and renal alterations
Leinonen, Henri, Rossi, Maarit, Salo, Antti M, Tiainen, Päivi, Hyvärinen, Jaana, Pitkänen, Marja, Sormunen, Raija, Miinalainen, Ilkka, Zhang, Chi, Soininen, Raija, Kivirikko, Kari I, Koskelainen, Ari, Tanila, Heikki, Myllyharju, Johanna, Koivunen, Peppi
Published in Human molecular genetics (01.09.2016)
Published in Human molecular genetics (01.09.2016)
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Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway
Hirsilä, Maija, Koivunen, Peppi, Xu, Leon, Seeley, Todd, Kivirikko, Kari I, Myllyharju, Johanna
Published in The FASEB journal (01.08.2005)
Published in The FASEB journal (01.08.2005)
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LOXL1 and LOXL4 are epigenetically silenced and can inhibit ras/extracellular signal-regulated kinase signaling pathway in human bladder cancer
GUOJUN WU, ZHONGMIN GUO, SIDRANSKY, David, XIAOFEI CHANG, MYOUNG SOOK KIM, NAGPAL, Jatin K, JUNWEI LIU, MAKI, Joni M, KIVIRIKKO, Kari I, ETHIER, Stephen P, TRINK, Barry
Published in Cancer research (Chicago, Ill.) (01.05.2007)
Published in Cancer research (Chicago, Ill.) (01.05.2007)
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Loss of Assembly of the Main Basement Membrane Collagen, Type IV, but Not Fibril-forming Collagens and Embryonic Death in Collagen Prolyl 4-Hydroxylase I Null Mice
Holster, Tiina, Pakkanen, Outi, Soininen, Raija, Sormunen, Raija, Nokelainen, Minna, Kivirikko, Kari I., Myllyharju, Johanna
Published in The Journal of biological chemistry (26.01.2007)
Published in The Journal of biological chemistry (26.01.2007)
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Tissue-specific Changes in the Hydroxylysine Content and Cross-links of Collagens and Alterations in Fibril Morphology in Lysyl Hydroxylase 1 Knock-out Mice
Takaluoma, Kati, Hyry, Marjo, Lantto, Juha, Sormunen, Raija, Bank, Ruud A., Kivirikko, Kari I., Myllyharju, Johanna, Soininen, Raija
Published in The Journal of biological chemistry (02.03.2007)
Published in The Journal of biological chemistry (02.03.2007)
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Molecular Characterization of the Principal Substrate Binding Site of the Ubiquitous Folding Catalyst Protein Disulfide Isomerase
Pirneskoski, Annamari, Klappa, Peter, Lobell, Mario, Williamson, Richard A., Byrne, Lee, Alanen, Heli I., Salo, Kirsi E.H., Kivirikko, Kari I., Freedman, Robert B., Ruddock, Lloyd W.
Published in The Journal of biological chemistry (12.03.2004)
Published in The Journal of biological chemistry (12.03.2004)
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Premature Aggregation of Type IV Collagen and Early Lethality in Lysyl Hydroxylase 3 Null Mice
Rautavuoma, Kati, Takaluoma, Kati, Sormunen, Raija, Myllyharju, Johanna, Kivirikko, Kari I., Soininen, Raija, Ruoslahti, Erkki
Published in Proceedings of the National Academy of Sciences - PNAS (28.09.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (28.09.2004)
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Inhibition of Hypoxia-inducible Factor (HIF) Hydroxylases by Citric Acid Cycle Intermediates: POSSIBLE LINKS BETWEEN CELL METABOLISM AND STABILIZATION OF HIF
Koivunen, Peppi, Hirsilä, Maija, Remes, Anne M, Hassinen, Ilmo E, Kivirikko, Kari I, Myllyharju, Johanna
Published in The Journal of biological chemistry (16.02.2007)
Published in The Journal of biological chemistry (16.02.2007)
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