Search Results - "Kirschner, E" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Dynamic balance of pro‐ and anti‐inflammatory signals controls disease and limits pathology

Dynamic balance of pro‐ and anti‐inflammatory signals controls disease and limits pathology

by Cicchese, Joseph M., Evans, Stephanie, Hult, Caitlin, Joslyn, Louis R., Wessler, Timothy, Millar, Jess A., Marino, Simeone, Cilfone, Nicholas A., Mattila, Joshua T., Linderman, Jennifer J., Kirschner, Denise E.
Published in Immunological reviews (01.09.2018)

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Journal Article

Macrophage polarization drives granuloma outcome during Mycobacterium tuberculosis infection

Macrophage polarization drives granuloma outcome during Mycobacterium tuberculosis infection

by Marino, Simeone, Cilfone, Nicholas A, Mattila, Joshua T, Linderman, Jennifer J, Flynn, JoAnne L, Kirschner, Denise E
Published in Infection and immunity (01.01.2015)

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Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms

Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms

by Mattila, Joshua T, Ojo, Olabisi O, Kepka-Lenhart, Diane, Marino, Simeone, Kim, Jin Hee, Eum, Seok Yong, Via, Laura E, Barry, 3rd, Clifton E, Klein, Edwin, Kirschner, Denise E, Morris, Jr, Sidney M, Lin, Philana Ling, Flynn, Joanne L
Published in The Journal of immunology (1950) (15.07.2013)

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Variability in tuberculosis granuloma T cell responses exists, but a balance of pro- and anti-inflammatory cytokines is associated with sterilization

Variability in tuberculosis granuloma T cell responses exists, but a balance of pro- and anti-inflammatory cytokines is associated with sterilization

by Gideon, Hannah Priyadarshini, Phuah, JiaYao, Myers, Amy J, Bryson, Bryan D, Rodgers, Mark A, Coleman, M Teresa, Maiello, Pauline, Rutledge, Tara, Marino, Simeone, Fortune, Sarah M, Kirschner, Denise E, Lin, Philana Ling, Flynn, JoAnne L
Published in PLoS pathogens (01.01.2015)

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Systems biology predicts that fibrosis in tuberculous granulomas may arise through macrophage-to-myofibroblast transformation

Systems biology predicts that fibrosis in tuberculous granulomas may arise through macrophage-to-myofibroblast transformation

by Evans, Stephanie, Butler, J Russell, Mattila, Joshua T, Kirschner, Denise E
Published in PLoS computational biology (28.12.2020)

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Concomitant immunity to M. tuberculosis infection

Concomitant immunity to M. tuberculosis infection

by Joslyn, Louis R, Flynn, JoAnne L, Kirschner, Denise E, Linderman, Jennifer J
Published in Scientific reports (01.12.2022)

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Optimizing tuberculosis treatment efficacy: Comparing the standard regimen with Moxifloxacin-containing regimens

Optimizing tuberculosis treatment efficacy: Comparing the standard regimen with Moxifloxacin-containing regimens

by Budak, Maral, Cicchese, Joseph M, Maiello, Pauline, Borish, H Jacob, White, Alexander G, Chishti, Harris B, Tomko, Jaime, Frye, L James, Fillmore, Daniel, Kracinovsky, Kara, Sakal, Jennifer, Scanga, Charles A, Lin, Philana Ling, Dartois, Véronique, Linderman, Jennifer J, Flynn, JoAnne L, Kirschner, Denise E
Published in PLoS computational biology (01.06.2023)

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Neutrophil Dynamics Affect Mycobacterium tuberculosis Granuloma Outcomes and Dissemination

Neutrophil Dynamics Affect Mycobacterium tuberculosis Granuloma Outcomes and Dissemination

by Hult, Caitlin, Mattila, Joshua T, Gideon, Hannah P, Linderman, Jennifer J, Kirschner, Denise E
Published in Frontiers in immunology (05.10.2021)

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Multi-scale modeling predicts a balance of tumor necrosis factor-α and interleukin-10 controls the granuloma environment during Mycobacterium tuberculosis infection

Multi-scale modeling predicts a balance of tumor necrosis factor-α and interleukin-10 controls the granuloma environment during Mycobacterium tuberculosis infection

by Cilfone, Nicholas A, Perry, Cory R, Kirschner, Denise E, Linderman, Jennifer J
Published in PloS one (15.07.2013)

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Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach

Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach

by Pienaar, Elsje, Sarathy, Jansy, Prideaux, Brendan, Dietzold, Jillian, Dartois, Véronique, Kirschner, Denise E, Linderman, Jennifer J
Published in PLoS computational biology (17.08.2017)

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Emergence and selection of isoniazid and rifampin resistance in tuberculosis granulomas

Emergence and selection of isoniazid and rifampin resistance in tuberculosis granulomas

by Pienaar, Elsje, Linderman, Jennifer J, Kirschner, Denise E
Published in PloS one (10.05.2018)

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Differential risk of tuberculosis reactivation among anti-TNF therapies is due to drug binding kinetics and permeability

Differential risk of tuberculosis reactivation among anti-TNF therapies is due to drug binding kinetics and permeability

by Fallahi-Sichani, Mohammad, Flynn, JoAnne L, Linderman, Jennifer J, Kirschner, Denise E
Published in The Journal of immunology (1950) (01.04.2012)

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Deletion of TGF-β1 Increases Bacterial Clearance by Cytotoxic T Cells in a Tuberculosis Granuloma Model

Deletion of TGF-β1 Increases Bacterial Clearance by Cytotoxic T Cells in a Tuberculosis Granuloma Model

by Warsinske, Hayley C, Pienaar, Elsje, Linderman, Jennifer J, Mattila, Joshua T, Kirschner, Denise E
Published in Frontiers in immunology (20.12.2017)

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Journal Article

Calibration methods to fit parameters within complex biological models

Calibration methods to fit parameters within complex biological models

by Nanda, Pariksheet, Kirschner, Denise E
Published in Frontiers in applied mathematics and statistics (2023)

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Journal Article

Intracellular bacillary burden reflects a burst size for Mycobacterium tuberculosis in vivo

Intracellular bacillary burden reflects a burst size for Mycobacterium tuberculosis in vivo

by Repasy, Teresa, Lee, Jinhee, Marino, Simeone, Martinez, Nuria, Kirschner, Denise E, Hendricks, Gregory, Baker, Stephen, Wilson, Andrew A, Kotton, Darrell N, Kornfeld, Hardy
Published in PLoS pathogens (01.02.2013)

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Journal Article

Both Pharmacokinetic Variability and Granuloma Heterogeneity Impact the Ability of the First-Line Antibiotics to Sterilize Tuberculosis Granulomas

Both Pharmacokinetic Variability and Granuloma Heterogeneity Impact the Ability of the First-Line Antibiotics to Sterilize Tuberculosis Granulomas

by Cicchese, Joseph M, Dartois, Véronique, Kirschner, Denise E, Linderman, Jennifer J
Published in Frontiers in pharmacology (24.03.2020)

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A computational model tracks whole-lung Mycobacterium tuberculosis infection and predicts factors that inhibit dissemination

A computational model tracks whole-lung Mycobacterium tuberculosis infection and predicts factors that inhibit dissemination

by Wessler, Timothy, Joslyn, Louis R, Borish, H Jacob, Gideon, Hannah P, Flynn, JoAnne L, Kirschner, Denise E, Linderman, Jennifer J
Published in PLoS computational biology (20.05.2020)

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Journal Article

NF-κB Signaling Dynamics Play a Key Role in Infection Control in Tuberculosis

NF-κB Signaling Dynamics Play a Key Role in Infection Control in Tuberculosis

by Fallahi-Sichani, Mohammad, Kirschner, Denise E, Linderman, Jennifer J
Published in Frontiers in physiology (01.01.2012)

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Journal Article

T cell transcription factor expression evolves over time in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques

T cell transcription factor expression evolves over time in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques

by Grant, Nicole L., Maiello, Pauline, Klein, Edwin, Lin, Philana Ling, Borish, H. Jacob, Tomko, Jaime, Frye, L. James, White, Alexander G., Kirschner, Denise E., Mattila, Joshua T., Flynn, JoAnne L.
Published in Cell reports (Cambridge) (17.05.2022)

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Journal Article

Spatial Organization and Recruitment of Non-Specific T Cells May Limit T Cell-Macrophage Interactions Within Mycobacterium tuberculosis Granulomas

Spatial Organization and Recruitment of Non-Specific T Cells May Limit T Cell-Macrophage Interactions Within Mycobacterium tuberculosis Granulomas

by Millar, Jess A, Butler, J Russell, Evans, Stephanie, Mattila, Joshua T, Linderman, Jennifer J, Flynn, JoAnne L, Kirschner, Denise E
Published in Frontiers in immunology (20.01.2021)

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