The Clinical Potential of Senolytic Drugs
Kirkland, James L., Tchkonia, Tamara, Zhu, Yi, Niedernhofer, Laura J., Robbins, Paul D.
Published in Journal of the American Geriatrics Society (JAGS) (01.10.2017)
Published in Journal of the American Geriatrics Society (JAGS) (01.10.2017)
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Journal Article
Sarcopenia: Aging-Related Loss of Muscle Mass and Function
Larsson, Lars, Degens, Hans, Li, Meishan, Salviati, Leonardo, Lee, Young Il, Thompson, Wesley, Kirkland, James L, Sandri, Marco
Published in Physiological reviews (01.01.2019)
Published in Physiological reviews (01.01.2019)
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Journal Article
Discovery, development, and future application of senolytics: theories and predictions
Wissler Gerdes, Erin O., Zhu, Yi, Tchkonia, Tamar, Kirkland, James L.
Published in The FEBS journal (01.06.2020)
Published in The FEBS journal (01.06.2020)
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Journal Article
Senescence and apoptosis: dueling or complementary cell fates?
Childs, Bennett G, Baker, Darren J, Kirkland, James L, Campisi, Judith, van Deursen, Jan M
Published in EMBO reports (01.11.2014)
Published in EMBO reports (01.11.2014)
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Journal Article
Cell senescence, the senescence-associated secretory phenotype, and cancers
Langhi Prata, Larissa G P, Tchkonia, Tamar, Kirkland, James L
Published in PLoS biology (21.09.2023)
Published in PLoS biology (21.09.2023)
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Journal Article
Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span
Robbins, Paul D, Jurk, Diana, Khosla, Sundeep, Kirkland, James L, LeBrasseur, Nathan K, Miller, Jordan D, Passos, João F, Pignolo, Robert J, Tchkonia, Tamar, Niedernhofer, Laura J
Published in Annual review of pharmacology and toxicology (06.01.2021)
Published in Annual review of pharmacology and toxicology (06.01.2021)
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Journal Article
Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty
Stout, Michael B, Justice, Jamie N, Nicklas, Barbara J, Kirkland, James L
Published in Physiology (Bethesda, Md.) (01.01.2017)
Published in Physiology (Bethesda, Md.) (01.01.2017)
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Journal Article
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
Saul, Dominik, Kosinsky, Robyn Laura, Atkinson, Elizabeth J., Doolittle, Madison L., Zhang, Xu, LeBrasseur, Nathan K., Pignolo, Robert J., Robbins, Paul D., Niedernhofer, Laura J., Ikeno, Yuji, Jurk, Diana, Passos, João F., Hickson, LaTonya J., Xue, Ailing, Monroe, David G., Tchkonia, Tamara, Kirkland, James L., Farr, Joshua N., Khosla, Sundeep
Published in Nature communications (16.08.2022)
Published in Nature communications (16.08.2022)
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Journal Article
Identification of HSP90 inhibitors as a novel class of senolytics
Fuhrmann-Stroissnigg, Heike, Ling, Yuan Yuan, Zhao, Jing, McGowan, Sara J., Zhu, Yi, Brooks, Robert W., Grassi, Diego, Gregg, Siobhan Q., Stripay, Jennifer L., Dorronsoro, Akaitz, Corbo, Lana, Tang, Priscilla, Bukata, Christina, Ring, Nadja, Giacca, Mauro, Li, Xuesen, Tchkonia, Tamara, Kirkland, James L., Niedernhofer, Laura J., Robbins, Paul D.
Published in Nature communications (04.09.2017)
Published in Nature communications (04.09.2017)
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Journal Article
Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity
Palmer, Allyson K, Tchkonia, Tamara, LeBrasseur, Nathan K, Chini, Eduardo N, Xu, Ming, Kirkland, James L
Published in Diabetes (New York, N.Y.) (01.07.2015)
Published in Diabetes (New York, N.Y.) (01.07.2015)
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Journal Article
Senolytics improve physical function and increase lifespan in old age
Xu, Ming, Pirtskhalava, Tamar, Farr, Joshua N., Weigand, Bettina M., Palmer, Allyson K., Weivoda, Megan M., Inman, Christina L., Ogrodnik, Mikolaj B., Hachfeld, Christine M., Fraser, Daniel G., Onken, Jennifer L., Johnson, Kurt O., Verzosa, Grace C., Langhi, Larissa G. P., Weigl, Moritz, Giorgadze, Nino, LeBrasseur, Nathan K., Miller, Jordan D., Jurk, Diana, Singh, Ravinder J., Allison, David B., Ejima, Keisuke, Hubbard, Gene B., Ikeno, Yuji, Cubro, Hajrunisa, Garovic, Vesna D., Hou, Xiaonan, Weroha, S. John, Robbins, Paul D., Niedernhofer, Laura J., Khosla, Sundeep, Tchkonia, Tamara, Kirkland, James L.
Published in Nature medicine (01.08.2018)
Published in Nature medicine (01.08.2018)
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Journal Article
Cellular senescence mediates fibrotic pulmonary disease
Schafer, Marissa J., White, Thomas A., Iijima, Koji, Haak, Andrew J., Ligresti, Giovanni, Atkinson, Elizabeth J., Oberg, Ann L., Birch, Jodie, Salmonowicz, Hanna, Zhu, Yi, Mazula, Daniel L., Brooks, Robert W., Fuhrmann-Stroissnigg, Heike, Pirtskhalava, Tamar, Prakash, Y. S., Tchkonia, Tamara, Robbins, Paul D., Aubry, Marie Christine, Passos, João F., Kirkland, James L., Tschumperlin, Daniel J., Kita, Hirohito, LeBrasseur, Nathan K.
Published in Nature communications (23.02.2017)
Published in Nature communications (23.02.2017)
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Journal Article
Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study
Justice, Jamie N., Nambiar, Anoop M., Tchkonia, Tamar, LeBrasseur, Nathan K., Pascual, Rodolfo, Hashmi, Shahrukh K., Prata, Larissa, Masternak, Michal M., Kritchevsky, Stephen B., Musi, Nicolas, Kirkland, James L.
Published in EBioMedicine (01.02.2019)
Published in EBioMedicine (01.02.2019)
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Journal Article