CD38 knockout natural killer cells expressing an affinity optimized CD38 chimeric antigen receptor successfully target acute myeloid leukemia with reduced effector cell fratricide
Gurney, Mark, Stikvoort, Arwen, Nolan, Emma, Kirkham-McCarthy, Lucy, Khoruzhenko, Stanislav, Shivakumar, Rama, Zweegman, Sonja, Van de Donk, Niels W C J, Mutis, Tuna, Szegezdi, Eva, Sarkar, Subhashis, O'Dwyer, Michael
Published in Haematologica (Roma) (01.02.2022)
Published in Haematologica (Roma) (01.02.2022)
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PSGL-1 decorated with sialyl Lewisa/x promotes high affinity binding of myeloma cells to P-selectin but is dispensable for E-selectin engagement
O’Dwyer, Michael, Kirkham-McCarthy, Lucy, Cerreto, Marina, Foà, Robin, Natoni, Alessandro
Published in Scientific reports (19.01.2024)
Published in Scientific reports (19.01.2024)
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Sialyltransferase inhibition leads to inhibition of tumor cell interactions with E-selectin, VCAM1, and MADCAM1, and improves survival in a human multiple myeloma mouse model
Natoni, Alessandro, Farrell, Mariah L, Harris, Sophie, Falank, Carolyne, Kirkham-McCarthy, Lucy, Macauley, Matthew S, Reagan, Michaela R, O'Dwyer, Michael
Published in Haematologica (Roma) (01.02.2020)
Published in Haematologica (Roma) (01.02.2020)
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Histone deacetylase complexes promote trinucleotide repeat expansions
Debacker, Kim, Frizzell, Aisling, Gleeson, Olive, Kirkham-McCarthy, Lucy, Mertz, Tony, Lahue, Robert S
Published in PLoS biology (01.02.2012)
Published in PLoS biology (01.02.2012)
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Sialofucosylation Enables Platelet Binding to Myeloma Cells via P-Selectin and Suppresses NK Cell-Mediated Cytotoxicity
Natoni, Alessandro, Cerreto, Marina, De Propris, Maria Stefania, Petrucci, Maria Teresa, Fazio, Francesca, Intoppa, Stefania, Milani, Maria Laura, Kirkham-McCarthy, Lucy, Henderson, Robert, Swan, Dawn, Guarini, Anna, O'Dwyer, Michael, Foà, Robin
Published in Cancers (01.04.2023)
Published in Cancers (01.04.2023)
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Inhibition of Sialylation Impairs Adhesion on Madcam-1 and E-Selectin and Sensitize Multiple Myeloma Cells to Bortezomib in a Xenograft Mouse Model
Natoni, Alessandro, Farrell, Mariah, Fairfield, Heather, Kirkham-McCarthy, Lucy, Macauley, Matt, Reagan, Michaela, O'Dwyer, Michael E
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Platelets Preferentially Bind to Myeloma Cells Bearing Sialofucosylated Structures and Protect Them from Natural Killer Cell-Mediated Cytotoxicity
Henderson, Robert, Kirkham-McCarthy, Lucy, Swan, Dawn, O'Dwyer, Michael E, Natoni, Alessandro
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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PSGL-1 decorated with sialyl Lewis a/x promotes high affinity binding of myeloma cells to P-selectin but is dispensable for E-selectin engagement
O'Dwyer, Michael, Kirkham-McCarthy, Lucy, Cerreto, Marina, Foà, Robin, Natoni, Alessandro
Published in Scientific reports (19.01.2024)
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Published in Scientific reports (19.01.2024)
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Targeting Siglec-7: A Novel Immunotherapeutic Approach to Potentiate the Cytotoxic Functions of Natural Killer Cells Against Multiple Myeloma
Daly, John, Duggan, Tony, Hu, Jinsong, Natoni, Alessandro, Sarkar, Subhashis, Kirkham-McCarthy, Lucy, McEllistrim, Cian, Krawczyk, Janusz, O'Dwyer, Michael
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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P-018: Optimized affinity CD38 CAR-NK cells with CD38 KO show promising in-vivo activity in a multiple myeloma model
O’Dwyer, Michael, Shevlin, Enda, Brophy, Sarah, Hermanson, David, Hintz, Hallie, Otto, Neil, Ettestad, Brianna, Kirkham-McCarthy, Lucy, Köylijärvi, Marjut, Hardwicke, David, Reilly, Mary
Published in Clinical lymphoma, myeloma and leukemia (01.08.2022)
Published in Clinical lymphoma, myeloma and leukemia (01.08.2022)
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Targeting CD38high Acute Myeloid Leukaemia with “Affinity Optimized” Chimeric Antigen Receptor and Membrane Bound TRAIL Expressing Natural Killer Cells
Nolan, Emma, Stikvoort, Arwen, Gurney, Mark, Burduli, Nutsa, Kirkham-McCarthy, Lucy, Daly, John, Van De Donk, Niels W. C.J., Mutis, Tuna, Sarkar, Subhashis, O'Dwyer, Michael E
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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NOVEL FACTORS THAT PROMOTE TRIPLET REPEAT EXPANSIONS
FRIZZELL, AISLING, GLEESON, OLIVE, CONCANNON, CLAIRE, DEBACKER, KIM, KIRKHAM-MCCARTHY, LUCY, LAHUE, ROBERT
Year of Publication 10.11.2011
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Year of Publication 10.11.2011
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