Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5
Mavrakis, Konstantinos J., McDonald, E. Robert, Schlabach, Michael R., Billy, Eric, Hoffman, Gregory R., deWeck, Antoine, Ruddy, David A., Venkatesan, Kavitha, Yu, Jianjun, McAllister, Gregg, Stump, Mark, deBeaumont, Rosalie, Ho, Samuel, Yue, Yingzi, Liu, Yue, Yan-Neale, Yan, Yang, Guizhi, Lin, Fallon, Yin, Hong, Gao, Hui, Kipp, D. Randal, Zhao, Songping, McNamara, Joshua T., Sprague, Elizabeth R., Zheng, Bing, Lin, Ying, Cho, Young Shin, Gu, Justin, Crawford, Kenneth, Ciccone, David, Vitari, Alberto C., Lai, Albert, Capka, Vladimir, Hurov, Kristen, Porter, Jeffery A., Tallarico, John, Mickanin, Craig, Lees, Emma, Pagliarini, Raymond, Keen, Nicholas, Schmelzle, Tobias, Hofmann, Francesco, Stegmeier, Frank, Sellers, William R.
Published in Science (American Association for the Advancement of Science) (11.03.2016)
Published in Science (American Association for the Advancement of Science) (11.03.2016)
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Journal Article
Mass-Dependent Bond Vibrational Dynamics Influence Catalysis by HIV-1 Protease
Kipp, D. Randal, Silva, Rafael G, Schramm, Vern L
Published in Journal of the American Chemical Society (07.12.2011)
Published in Journal of the American Chemical Society (07.12.2011)
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Journal Article
Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors
Taylor, Alexander M., Williams, Bret R., Giordanetto, Fabrizio, Kelley, Elizabeth H., Lescarbeau, André, Shortsleeves, Kelley, Tang, Yong, Walters, W. Patrick, Arrazate, Alfonso, Bowman, Christine, Brophy, Erin, Chan, Emily W., Deshmukh, Gauri, Greisman, Jack B., Hunsaker, Thomas L., Kipp, D. Randal, Saenz Lopez-Larrocha, Pablo, Maddalo, Danilo, Martin, Iain J., Maragakis, Paul, Merchant, Mark, Murcko, Mark, Nisonoff, Hunter, Nguyen, Vi, Nguyen, Vy, Orozco, Olivia, Owen, Christopher, Pierce, Levi, Schmidt, Molly, Shaw, David E., Smith, Sherri, Therrien, Eric, Tran, John C., Watters, Jim, Waters, Nigel J., Wilbur, Jeremy, Willmore, Lindsay
Published in Journal of medicinal chemistry (12.10.2023)
Published in Journal of medicinal chemistry (12.10.2023)
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Journal Article
Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia
Varkaris, Andreas, Pazolli, Ermira, Gunaydin, Hakan, Wang, Qi, Pierce, Levi, Boezio, Alessandro A, Bulku, Artemisa, DiPietro, Lucian, Fridrich, Cary, Frost, Adam, Giordanetto, Fabrizio, Hamilton, Erika P, Harris, Katherine, Holliday, Michael, Hunter, Tamieka L, Iskandar, Amanda, Ji, Yongli, Larivée, Alexandre, LaRochelle, Jonathan R, Lescarbeau, André, Llambi, Fabien, Lormil, Brenda, Mader, Mary M, Mar, Brenton G, Martin, Iain, McLean, Thomas H, Michelsen, Klaus, Pechersky, Yakov, Puente-Poushnejad, Erika, Raynor, Kevin, Rogala, Dipali, Samadani, Ramin, Schram, Alison M, Shortsleeves, Kelley, Swaminathan, Sweta, Tajmir, Shahein, Tan, Gege, Tang, Yong, Valverde, Roberto, Wehrenberg, Bryan, Wilbur, Jeremy, Williams, Bret R, Zeng, Hongtao, Zhang, Hanmo, Walters, W Patrick, Wolf, Beni B, Shaw, David E, Bergstrom, Donald A, Watters, James, Fraser, James S, Fortin, Pascal D, Kipp, D Randal
Published in Cancer discovery (08.02.2024)
Published in Cancer discovery (08.02.2024)
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Journal Article
Suppression of in Vivo β-Amyloid Peptide Toxicity by Overexpression of the HSP-16.2 Small Chaperone Protein
Fonte, Virginia, Kipp, D. Randal, Yerg, John, Merin, David, Forrestal, Margaret, Wagner, Eileen, Roberts, Christine M., Link, Christopher D.
Published in The Journal of biological chemistry (11.01.2008)
Published in The Journal of biological chemistry (11.01.2008)
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Journal Article
Enzyme-Dependent Lysine Deprotonation in EZH2 Catalysis
Kipp, D. Randal, Quinn, Christopher M, Fortin, Pascal D
Published in Biochemistry (Easton) (01.10.2013)
Published in Biochemistry (Easton) (01.10.2013)
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Journal Article
The Novolactone Natural Product Disrupts the Allosteric Regulation of Hsp70
Hassan, A. Quamrul, Kirby, Christina A., Zhou, Wenlai, Schuhmann, Tim, Kityk, Roman, Kipp, D. Randal, Baird, Jason, Chen, Jinyun, Chen, Yaoyu, Chung, Franklin, Hoepfner, Dominic, Movva, N. Rao, Pagliarini, Raymond, Petersen, Frank, Quinn, Christopher, Quinn, Douglas, Riedl, Ralph, Schmitt, Esther K., Schitter, Anne, Stams, Travis, Studer, Christian, Fortin, Pascal D., Mayer, Matthias P., Sadlish, Heather
Published in Chemistry & biology (22.01.2015)
Published in Chemistry & biology (22.01.2015)
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Journal Article
Suppression of in Vivo β-Amyloid Peptide Toxicity by Overexpression of the HSP-16.2 Small Chaperone Protein
Virginia Fonte, D. Randal Kipp, John Yerg III, David Merin, Margaret Forrestal, Eileen Wagner, Christine M. Roberts, Christopher D. Link
Published in The Journal of biological chemistry (11.01.2008)
Published in The Journal of biological chemistry (11.01.2008)
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Journal Article
The Novolactone Natural Product Disrupts the Allosteric Regulation of Hsp70
Hassan, A. Quamrul, Kirby, Christina A., Zhou, Wenlai, Schuhmann, Tim, Kityk, Roman, Kipp, D. Randal, Baird, Jason, Chen, Jinyun, Chen, Yaoyu, Chung, Franklin, Hoepfner, Dominic, Movva, N. Rao, Pagliarini, Raymond, Petersen, Frank, Quinn, Christopher, Quinn, Douglas, Riedl, Ralph, Schmitt, Esther K., Schitter, Anne, Stams, Travis, Studer, Christian, Fortin, Pascal D., Mayer, Matthias P., Sadlish, Heather
Published in Chemistry & biology (01.01.2015)
Published in Chemistry & biology (01.01.2015)
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Journal Article