Drug-induced lenticular opacity and accumulation of cholesterol-related substances in the lens cortex of dogs
Iwasaki, Hiroshi, Wakamatsu, Masaki, Sugihara, Kazunari, Kamio, Kyohei, Tsuji, Satoshi, Morita, Junya, Kurihara, Yasuhiro, Izumi, Tomoko, Nishimoto, Tomohiro, Kinoshita, Kohnosuke, Nakanishi, Yutaka, Sasaki, Minoru
Published in Journal of toxicological sciences (01.01.2020)
Published in Journal of toxicological sciences (01.01.2020)
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Preclinical disposition of MGS0274 besylate, a prodrug of a potent group II metabotropic glutamate receptor agonist MGS0008 for the treatment of schizophrenia
Kinoshita, Kohnosuke, Ochi, Motoki, Iwata, Katsuya, Fukasawa, Misako, Yamaguchi, Jun‐ichi
Published in Pharmacology research & perspectives (01.10.2019)
Published in Pharmacology research & perspectives (01.10.2019)
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A Strategy for assessing potential drug-drug interactions of a concomitant agent against a drug absorbed via an intestinal transporter in humans
Mizuno-Yasuhira, Akiko, Nakai, Yasuhiro, Gunji, Emi, Uchida, Saeko, Takahashi, Teisuke, Kinoshita, Kohnosuke, Jingu, Shigeji, Sakai, Soichi, Samukawa, Yoshishige, Yamaguchi, Jun-Ichi
Published in Drug metabolism and disposition (01.09.2014)
Published in Drug metabolism and disposition (01.09.2014)
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Preclinical Metabolism and Disposition of TP0473292, a Novel Oral Prodrug of the Potent Metabotropic Glutamate 2/3 Receptor Antagonist TP0178894 for the Treatment of Depression
Inatani, Shoko, Ochi, Motoki, Kinoshita, Kohnosuke, Yamaguchi, Jun-Ichi, Endo, Hiromi
Published in Drug metabolism and disposition (01.05.2023)
Published in Drug metabolism and disposition (01.05.2023)
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Evaluation of the Safety, Tolerability, and Pharmacokinetic Profiles of TP0473292 (TS-161), A Prodrug of a Novel Orthosteric mGlu2/3 Receptor Antagonist TP0178894, in Healthy Subjects and Its Antidepressant-Like Effects in Rodents
Watanabe, Mai, Marcy, Brian, Hiroki, Ayano, Watase, Hirotaka, Kinoshita, Kohnosuke, Iijima, Michihiko, Marumo, Toshiyuki, Zarate, Carlos A, Chaki, Shigeyuki
Published in The international journal of neuropsychopharmacology (11.02.2022)
Published in The international journal of neuropsychopharmacology (11.02.2022)
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Journal Article
Safety and pharmacokinetic profiles of MGS0274 besylate (TS‐134), a novel metabotropic glutamate 2/3 receptor agonist prodrug, in healthy subjects
Watanabe, Mai, Marcy, Brian, Kinoshita, Kohnosuke, Fukasawa, Misako, Hikichi, Hirohiko, Chaki, Shigeyuki, Okuyama, Shigeru, Gevorkyan, Hakop, Yoshida, Shigeru
Published in British journal of clinical pharmacology (01.11.2020)
Published in British journal of clinical pharmacology (01.11.2020)
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Bottom-up physiologically based pharmacokinetic modelling for predicting the human pharmacokinetic profiles of the ester prodrug MGS0274 and its active metabolite MGS0008, a metabotropic glutamate 2/3 receptor agonist
Ochi, Motoki, Kinoshita, Kohnosuke, Yamaguchi, Jun-ichi, Endo, Hiromi
Published in Xenobiotica (01.02.2022)
Published in Xenobiotica (01.02.2022)
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Discovery of MGS0274, an ester prodrug of a metabotropic glutamate receptor 2/3 agonist with improved oral bioavailability
Urabe, Hiroki, Miyakoshi, Naoki, Ohtake, Norikazu, Nozoe, Akiko, Ochi, Motoki, Fukasawa, Misako, Kinoshita, Kohnosuke, Yamaguchi, Jun-ichi, Marumo, Toshiyuki, Hikichi, Hirohiko, Chaki, Shigeyuki, Hashihayata, Takashi
Published in European journal of medicinal chemistry (01.10.2020)
Published in European journal of medicinal chemistry (01.10.2020)
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Development, validation, and application of a surrogate analyte method for determining N-acetyl-l-aspartyl-l-glutamic acid levels in rat brain, plasma, and cerebrospinal fluid
Kinoshita, Kohnosuke, Arai, Kotaro, Kawaura, Kazuaki, Hiyoshi, Tetsuaki, Yamaguchi, Jun-ichi
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.10.2015)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.10.2015)
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Effects of a glycine transporter-1 inhibitor and D-serine on MK-801-induced immobility in the forced swimming test in rats
Kawaura, Kazuaki, Koike, Hiroyuki, Kinoshita, Kohnosuke, Kambe, Daiji, Kaku, Ayaka, Karasawa, Jun-ichi, Chaki, Shigeyuki, Hikichi, Hirohiko
Published in Behavioural brain research (01.02.2015)
Published in Behavioural brain research (01.02.2015)
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A sensitive and selective method for the quantitative analysis of miglitol in rat plasma using unique solid-phase extraction coupled with liquid chromatography-tandem mass spectrometry
Mizuno-Yasuhira, Akiko, Kinoshita, Kohnosuke, Jingu, Shigeji, Yamaguchi, Jun-ichi
Published in Biomedical chromatography (01.10.2014)
Published in Biomedical chromatography (01.10.2014)
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