First‐in‐human assessment of PRX002, an anti–α‐synuclein monoclonal antibody, in healthy volunteers
Schenk, Dale B., Koller, Martin, Ness, Daniel K., Griffith, Sue G., Grundman, Michael, Zago, Wagner, Soto, Jay, Atiee, George, Ostrowitzki, Susanne, Kinney, Gene G.
Published in Movement disorders (01.02.2017)
Published in Movement disorders (01.02.2017)
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First-in-human assessment of PRX002, an anti-[alpha]-synuclein monoclonal antibody, in healthy volunteers
Schenk, Dale B, Koller, Martin, Ness, Daniel K, Griffith, Sue G, Grundman, Michael, Zago, Wagner, Soto, Jay, Atiee, George, Ostrowitzki, Susanne, Kinney, Gene G
Published in Movement disorders (01.02.2017)
Published in Movement disorders (01.02.2017)
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Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis
Sperling, Reisa, Dr, Salloway, Stephen, Prof, Brooks, David J, Prof, Tampieri, Donatella, MD, Barakos, Jerome, MD, Fox, Nick C, Prof, Raskind, Murray, Prof, Sabbagh, Marwan, MD, Honig, Lawrence S, MD, Porsteinsson, Anton P, Prof, Lieberburg, Ivan, MD, Arrighi, H Michael, PhD, Morris, Kristen A, MS, Lu, Yuan, MS, Liu, Enchi, PhD, Gregg, Keith M, PhD, Brashear, H Robert, MD, Kinney, Gene G, PhD, Black, Ronald, MD, Grundman, Michael, MD
Published in Lancet neurology (01.03.2012)
Published in Lancet neurology (01.03.2012)
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First-in-Human Phase I/II Study of NEOD001 in Patients With Light Chain Amyloidosis and Persistent Organ Dysfunction
Gertz, Morie A, Landau, Heather, Comenzo, Raymond L, Seldin, David, Weiss, Brendan, Zonder, Jeffrey, Merlini, Giampaolo, Schönland, Stefan, Walling, Jackie, Kinney, Gene G, Koller, Martin, Schenk, Dale B, Guthrie, Spencer D, Liedtke, Michaela
Published in Journal of clinical oncology (01.04.2016)
Published in Journal of clinical oncology (01.04.2016)
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The mechanism of action, pharmacological characteristics, and clinical utility of the amyloid depleter birtamimab for the potential treatment of AL amyloidosis
Palladini, Giovanni, Liedtke, Michaela, Zago, Wagner, Dolan, Phil, Kinney, Gene G, Gertz, Morie A
Published in Leukemia & lymphoma (02.07.2024)
Published in Leukemia & lymphoma (02.07.2024)
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Birtamimab plus standard of care in light-chain amyloidosis: the phase 3 randomized placebo-controlled VITAL trial
Gertz, Morie A., Cohen, Adam D., Comenzo, Raymond L., Kastritis, Efstathios, Landau, Heather J., Libby, Edward N., Liedtke, Michaela, Sanchorawala, Vaishali, Schönland, Stefan, Wechalekar, Ashutosh, Zonder, Jeffrey A., Palladini, Giovanni, Walling, Jackie, Guthrie, Spencer, Nie, Christie, Karp, Carol, Jin, Yuying, Kinney, Gene G., Merlini, Giampaolo
Published in Blood (05.10.2023)
Published in Blood (05.10.2023)
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PRX004 in variant amyloid transthyretin (ATTRv) amyloidosis: results of a phase 1, open-label, dose-escalation study
Suhr, Ole B, Grogan, Martha, Silva, Ana Martins da, Karam, Chafic, Garcia-Pavia, Pablo, Drachman, Brian, Zago, Wagner, Tripuraneni, Radhika, Kinney, Gene G
Published in Amyloid (29.10.2024)
Published in Amyloid (29.10.2024)
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Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers
De Felice, Fernanda G, Wu, Diana, Lambert, Mary P, Fernandez, Sara J, Velasco, Pauline T, Lacor, Pascale N, Bigio, Eileen H, Jerecic, Jasna, Acton, Paul J, Shughrue, Paul J, Chen-Dodson, Elizabeth, Kinney, Gene G, Klein, William L
Published in Neurobiology of aging (01.09.2008)
Published in Neurobiology of aging (01.09.2008)
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Journal Article
PRX012 induces microglia‐mediated clearance of pyroglutamate‐modified Aβ in Alzheimer’s Disease brain tissue
Tam, Stephen, Zhang, Gang, Li, Lauri, Elmaarouf, Abderrahman, Skov, Michael, Dolan, Philip, Kinney, Gene G, Campbell, Brian, Zago, Wagner M
Published in Alzheimer's & dementia (01.12.2021)
Published in Alzheimer's & dementia (01.12.2021)
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Novel conformation-specific monoclonal antibodies against amyloidogenic forms of transthyretin
Higaki, Jeffrey N., Chakrabartty, Avi, Galant, Natalie J., Hadley, Kevin C., Hammerson, Bradley, Nijjar, Tarlochan, Torres, Ronald, Tapia, Jose R., Salmans, Joshua, Barbour, Robin, Tam, Stephen J., Flanagan, Ken, Zago, Wagner, Kinney, Gene G.
Published in Amyloid (01.06.2016)
Published in Amyloid (01.06.2016)
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Inhibition of Calcineurin-mediated Endocytosis and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors Prevents Amyloid β Oligomer-induced Synaptic Disruption
Zhao, Wei-Qin, Santini, Francesca, Breese, Robert, Ross, Dave, Zhang, Xiaohua Douglas, Stone, David J., Ferrer, Marc, Townsend, Matthew, Wolfe, Abigail L., Seager, Matthew A., Kinney, Gene G., Shughrue, Paul J., Ray, William J.
Published in The Journal of biological chemistry (05.03.2010)
Published in The Journal of biological chemistry (05.03.2010)
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Sustained levels of antibodies against Aβ in amyloid-rich regions of the CNS following intravenous dosing in human APP transgenic mice
Bard, Frédérique, Fox, Michael, Friedrich, Stuart, Seubert, Peter, Schenk, Dale, Kinney, Gene G., Yednock, Ted
Published in Experimental neurology (01.11.2012)
Published in Experimental neurology (01.11.2012)
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Journal Article
Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia
Lindsley, Craig W, Shipe, William D, Wolkenberg, Scott E, Theberge, Cory R, Williams, Jr, David L, Sur, Cyrille, Kinney, Gene G
Published in Current topics in medicinal chemistry (01.04.2006)
Published in Current topics in medicinal chemistry (01.04.2006)
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Selective activation of the M₁ muscarinic acetylcholine receptor achieved by allosteric potentiation
Ma, Lei, Seager, Matthew, Wittmann, Marion, Jacobson, Marlene, Bickel, Denise, Burno, Maryann, Jones, Keith, Graufelds, Valerie Kuzmick, Xu, Guangping, Pearson, Michelle, McCampbell, Alexander, Gaspar, Renee, Shughrue, Paul, Danziger, Andrew, Regan, Christopher, Flick, Rose, Pascarella, Danette, Garson, Susan, Doran, Scott, Kreatsoulas, Constantine, Veng, Lone, Lindsley, Craig W, Shipe, William, Kuduk, Scott, Sur, Cyrille, Kinney, Gene, Seabrook, Guy R, Ray, William J
Published in Proceedings of the National Academy of Sciences - PNAS (15.09.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (15.09.2009)
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Neutralization of soluble, synaptotoxic amyloid β species by antibodies is epitope specific
Zago, Wagner, Buttini, Manuel, Comery, Thomas A, Nishioka, Christopher, Gardai, Shyra J, Seubert, Peter, Games, Dora, Bard, Frédérique, Schenk, Dale, Kinney, Gene G
Published in The Journal of neuroscience (22.02.2012)
Published in The Journal of neuroscience (22.02.2012)
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Journal Article
Vascular alterations in PDAPP mice after anti-Aβ immunotherapy: Implications for amyloid-related imaging abnormalities
Zago, Wagner, Schroeter, Sally, Guido, Teresa, Khan, Karen, Seubert, Peter, Yednock, Ted, Schenk, Dale, Gregg, Keith M, Games, Dora, Bard, Frédérique, Kinney, Gene G
Published in Alzheimer's & dementia (01.10.2013)
Published in Alzheimer's & dementia (01.10.2013)
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Journal Article
A Novel Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Has in Vivo Activity and Antipsychotic-Like Effects in Rat Behavioral Models
Kinney, Gene G, O'Brien, Julie A, Lemaire, Wei, Burno, Maryann, Bickel, Denise J, Clements, Michelle K, Chen, Tsing-Bau, Wisnoski, David D, Lindsley, Craig W, Tiller, Philip R, Smith, Sheri, Jacobson, Marlene A, Sur, Cyrille, Duggan, Mark E, Pettibone, Douglas J, Conn, P Jeffrey, Williams, Jr, David L
Published in The Journal of pharmacology and experimental therapeutics (01.04.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2005)
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Metabotropic Glutamate Subtype 5 Receptors Modulate Locomotor Activity and Sensorimotor Gating in Rodents
Kinney, Gene G, Burno, Maryann, Campbell, Una C, Hernandez, Lisa M, Rodriguez, Dana, Bristow, Linda J, Conn, P Jeffrey
Published in The Journal of pharmacology and experimental therapeutics (01.07.2003)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2003)
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