Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum
Pholcharee, Tossapol, Oyen, David, Flores-Garcia, Yevel, Gonzalez-Paez, Gonzalo, Han, Zhen, Williams, Katherine L., Volkmuth, Wayne, Emerling, Daniel, Locke, Emily, Richter King, C., Zavala, Fidel, Wilson, Ian A.
Published in Nature communications (16.02.2021)
Published in Nature communications (16.02.2021)
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Identification of domains within Pfs230 that elicit transmission blocking antibody responses
Tachibana, Mayumi, Miura, Kazutoyo, Takashima, Eizo, Morita, Masayuki, Nagaoka, Hikaru, Zhou, Luwen, Long, Carole A., Richter King, C., Torii, Motomi, Tsuboi, Takafumi, Ishino, Tomoko
Published in Vaccine (22.03.2019)
Published in Vaccine (22.03.2019)
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A malaria vaccine adjuvant based on recombinant antigen binding to liposomes
Huang, Wei-Chiao, Deng, Bingbing, Lin, Cuiyan, Carter, Kevin A., Geng, Jumin, Razi, Aida, He, Xuedan, Chitgupi, Upendra, Federizon, Jasmin, Sun, Boyang, Long, Carole A., Ortega, Joaquin, Dutta, Sheetij, King, C. Richter, Miura, Kazutoyo, Lee, Shwu-Maan, Lovell, Jonathan F.
Published in Nature nanotechnology (01.12.2018)
Published in Nature nanotechnology (01.12.2018)
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Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein
Oyen, David, Torres, Jonathan L., Wille-Reece, Ulrike, Ockenhouse, Christian F., Emerling, Daniel, Glanville, Jacob, Volkmuth, Wayne, Flores-Garcia, Yevel, Zavala, Fidel, Ward, Andrew B., King, C. Richter, Wilson, Ian A.
Published in Proceedings of the National Academy of Sciences - PNAS (28.11.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (28.11.2017)
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Optimization of an in vivo model to study immunity to Plasmodium falciparum pre-erythrocytic stages
Flores-Garcia, Yevel, Herrera, Sonia M, Jhun, Hugo, Pérez-Ramos, Daniel W, King, C Richter, Locke, Emily, Raghunandan, Ramadevi, Zavala, Fidel
Published in Malaria journal (18.12.2019)
Published in Malaria journal (18.12.2019)
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Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45
Kundu, Prasun, Semesi, Anthony, Jore, Matthijs M., Morin, Merribeth J., Price, Virginia L., Liang, Alice, Li, Jingxing, Miura, Kazutoyo, Sauerwein, Robert W., King, C. Richter, Julien, Jean-Philippe
Published in Nature communications (26.10.2018)
Published in Nature communications (26.10.2018)
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A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies
Sanders, Rogier W, Derking, Ronald, Cupo, Albert, Julien, Jean-Philippe, Yasmeen, Anila, de Val, Natalia, Kim, Helen J, Blattner, Claudia, de la Peña, Alba Torrents, Korzun, Jacob, Golabek, Michael, de Los Reyes, Kevin, Ketas, Thomas J, van Gils, Marit J, King, C Richter, Wilson, Ian A, Ward, Andrew B, Klasse, P J, Moore, John P
Published in PLoS pathogens (01.09.2013)
Published in PLoS pathogens (01.09.2013)
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Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25
Scally, Stephen W., McLeod, Brandon, Bosch, Alexandre, Miura, Kazutoyo, Liang, Qi, Carroll, Sean, Reponen, Sini, Nguyen, Ngan, Giladi, Eldar, Rämisch, Sebastian, Yusibov, Vidadi, Bradley, Allan, Lemiale, Franck, Schief, William R., Emerling, Daniel, Kellam, Paul, King, C. Richter, Julien, Jean-Philippe
Published in Nature communications (16.11.2017)
Published in Nature communications (16.11.2017)
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Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25
McLeod, Brandon, Miura, Kazutoyo, Scally, Stephen W., Bosch, Alexandre, Nguyen, Ngan, Shin, Hanjun, Kim, Dongkyoon, Volkmuth, Wayne, Rämisch, Sebastian, Chichester, Jessica A., Streatfield, Stephen, Woods, Colleen, Schief, William R., Emerling, Daniel, King, C. Richter, Julien, Jean-Philippe
Published in Nature communications (24.09.2019)
Published in Nature communications (24.09.2019)
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Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein
Oyen, David, Torres, Jonathan L, Aoto, Phillip C, Flores-Garcia, Yevel, Binter, Špela, Pholcharee, Tossapol, Carroll, Sean, Reponen, Sini, Wash, Rachael, Liang, Qi, Lemiale, Franck, Locke, Emily, Bradley, Allan, King, C Richter, Emerling, Daniel, Kellam, Paul, Zavala, Fidel, Ward, Andrew B, Wilson, Ian A
Published in PLoS pathogens (09.03.2020)
Published in PLoS pathogens (09.03.2020)
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Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9
Julien, Jean-Philippe, Lee, Jeong Hyun, Cupo, Albert, Murin, Charles D., Derking, Ronald, Hoffenberg, Simon, Caulfield, Michael J., King, C. Richter, Marozsan, Andre J., Klasse, Per Johan, Sanders, Rogier W., Moore, John P., Wilson, Ian A., Ward, Andrew B.
Published in Proceedings of the National Academy of Sciences - PNAS (12.03.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (12.03.2013)
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Breadth of humoral immune responses to the C-terminus of the circumsporozoite protein is associated with protective efficacy induced by the RTS,S malaria vaccine
Chaudhury, Sidhartha, MacGill, Randall S., Early, Angela M., Bolton, Jessica S., King, C. Richter, Locke, Emily, Pierson, Tony, Wirth, Dyann F., Neafsey, Daniel E., Bergmann-Leitner, Elke S.
Published in Vaccine (05.02.2021)
Published in Vaccine (05.02.2021)
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Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230
Ivanochko, Danton, Fabra-García, Amanda, Teelen, Karina, van de Vegte-Bolmer, Marga, van Gemert, Geert-Jan, Newton, Jocelyn, Semesi, Anthony, de Bruijni, Marloes, Bolscher, Judith, Ramjith, Jordache, Szabat, Marta, Vogt, Stefanie, Kraft, Lucas, Duncan, Sherie, Lee, Shwu-Maan, Kamya, Moses R., Feeney, Margaret E., Jagannathan, Prasanna, Greenhouse, Bryan, Sauerwein, Robert W., Richter King, C., MacGill, Randall S., Bousema, Teun, Jore, Matthijs M., Julien, Jean-Philippe
Published in Immunity (Cambridge, Mass.) (14.02.2023)
Published in Immunity (Cambridge, Mass.) (14.02.2023)
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A novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum
Beutler, Nathan, Pholcharee, Tossapol, Oyen, David, Flores-Garcia, Yevel, MacGill, Randall S, Garcia, Elijah, Calla, Jaeson, Parren, Mara, Yang, Linlin, Volkmuth, Wayne, Locke, Emily, Regules, Jason A, Dutta, Sheetij, Emerling, Daniel, Early, Angela M, Neafsey, Daniel E, Winzeler, Elizabeth A, King, C Richter, Zavala, Fidel, Burton, Dennis R, Wilson, Ian A, Rogers, Thomas F
Published in PLoS pathogens (01.03.2022)
Published in PLoS pathogens (01.03.2022)
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A C-terminal Pfs48/45 malaria transmission-blocking vaccine candidate produced in the baculovirus expression system
Lee, Shwu-Maan, Hickey, John M., Miura, Kazutoyo, Joshi, Sangeeta B., Volkin, David B., King, C. Richter, Plieskatt, Jordan L.
Published in Scientific reports (15.01.2020)
Published in Scientific reports (15.01.2020)
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Safety, tolerability, and Plasmodium falciparum transmission-reducing activity of monoclonal antibody TB31F: a single-centre, open-label, first-in-human, dose-escalation, phase 1 trial in healthy malaria-naive adults
van der Boor, Saskia C, Smit, Merel J, van Beek, Stijn W, Ramjith, Jordache, Teelen, Karina, van de Vegte-Bolmer, Marga, van Gemert, Geert-Jan, Pickkers, Peter, Wu, Yimin, Locke, Emily, Lee, Shwu-Maan, Aponte, John, King, C Richter, Birkett, Ashley J, Miura, Kazutoyo, Ayorinde, Morolayo A, Sauerwein, Robert W, ter Heine, Rob, Ockenhouse, Christian F, Bousema, Teun, Jore, Matthijs M, McCall, Matthew B B
Published in The Lancet infectious diseases (01.11.2022)
Published in The Lancet infectious diseases (01.11.2022)
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Affinity-matured homotypic interactions induce spectrum of PfCSP structures that influence protection from malaria infection
Martin, Gregory M., Torres, Jonathan L., Pholcharee, Tossapol, Oyen, David, Flores-Garcia, Yevel, Gibson, Grace, Moskovitz, Re’em, Beutler, Nathan, Jung, Diana D., Copps, Jeffrey, Lee, Wen-Hsin, Gonzalez-Paez, Gonzalo, Emerling, Daniel, MacGill, Randall S., Locke, Emily, King, C. Richter, Zavala, Fidel, Wilson, Ian A., Ward, Andrew B.
Published in Nature communications (28.07.2023)
Published in Nature communications (28.07.2023)
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Characterization of two in vivo challenge models to measure functional activity of monoclonal antibodies to Plasmodium falciparum circumsporozoite protein
Raghunandan, Rama, Mayer, Bryan T, Flores-Garcia, Yevel, Gerber, Monica W, Gottardo, Raphael, Jhun, Hugo, Herrera, Sonia M, Perez-Ramos, Daniel W, Locke, Emily, King, C Richter, Zavala, Fidel
Published in Malaria journal (17.03.2020)
Published in Malaria journal (17.03.2020)
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Cryo-EM structure of P. falciparum circumsporozoite protein with a vaccine-elicited antibody is stabilized by somatically mutated inter-Fab contacts
Oyen, David, Torres, Jonathan L, Cottrell, Christopher A, Richter King, C, Wilson, Ian A, Ward, Andrew B
Published in Science advances (01.10.2018)
Published in Science advances (01.10.2018)
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Expression and purification optimization of an N-terminal Pfs230 transmission-blocking vaccine candidate
Lee, Shwu-Maan, Plieskatt, Jordan, Krishnan, Seetha, Raina, Monika, Harishchandra, Rakeshkumar, King, C. Richter
Published in Protein expression and purification (01.08.2019)
Published in Protein expression and purification (01.08.2019)
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