Single-Stranded siRNAs Activate RNAi in Animals
Lima, Walt F., Prakash, Thazha P., Murray, Heather M., Kinberger, Garth A., Li, Wenyu, Chappell, Alfred E., Li, Cheryl S., Murray, Susan F., Gaus, Hans, Seth, Punit P., Swayze, Eric E., Crooke, Stanley T.
Published in Cell (31.08.2012)
Published in Cell (31.08.2012)
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Journal Article
Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor
Schmidt, Karsten, Prakash, Thazha P, Donner, Aaron J, Kinberger, Garth A, Gaus, Hans J, Low, Audrey, Østergaard, Michael E, Bell, Melanie, Swayze, Eric E, Seth, Punit P
Published in Nucleic acids research (17.03.2017)
Published in Nucleic acids research (17.03.2017)
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Journal Article
Comprehensive Structure–Activity Relationship of Triantennary N‑Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes
Prakash, Thazha P, Yu, Jinghua, Migawa, Michael T, Kinberger, Garth A, Wan, W. Brad, Østergaard, Michael E, Carty, Recaldo L, Vasquez, Guillermo, Low, Audrey, Chappell, Alfred, Schmidt, Karsten, Aghajan, Mariam, Crosby, Jeff, Murray, Heather M, Booten, Sheri L, Hsiao, Jill, Soriano, Armand, Machemer, Todd, Cauntay, Patrick, Burel, Sebastien A, Murray, Susan F, Gaus, Hans, Graham, Mark J, Swayze, Eric E, Seth, Punit P
Published in Journal of medicinal chemistry (24.03.2016)
Published in Journal of medicinal chemistry (24.03.2016)
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Journal Article
Efficient Synthesis and Biological Evaluation of 5′-GalNAc Conjugated Antisense Oligonucleotides
Østergaard, Michael E, Yu, Jinghua, Kinberger, Garth A, Wan, W. Brad, Migawa, Michael T, Vasquez, Guillermo, Schmidt, Karsten, Gaus, Hans J, Murray, Heather M, Low, Audrey, Swayze, Eric E, Prakash, Thazha P, Seth, Punit P
Published in Bioconjugate chemistry (19.08.2015)
Published in Bioconjugate chemistry (19.08.2015)
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Journal Article
Synergistic effect of phosphorothioate, 5′-vinylphosphonate and GalNAc modifications for enhancing activity of synthetic siRNA
Prakash, Thazha P., Kinberger, Garth A., Murray, Heather M., Chappell, Alfred, Riney, Stan, Graham, Mark J., Lima, Walt F., Swayze, Eric E., Seth, Punit P.
Published in Bioorganic & medicinal chemistry letters (15.06.2016)
Published in Bioorganic & medicinal chemistry letters (15.06.2016)
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Journal Article
Dose-dependent reduction of somatic expansions but not Htt aggregates by di-valent siRNA-mediated silencing of MSH3 in HdhQ111 mice
Driscoll, Rachelle, Hampton, Lucas, Abraham, Neeta A, Larigan, J Douglas, Joseph, Nadine F, Hernandez-Vega, Juan C, Geisler, Sarah, Yang, Fu-Chia, Deninger, Matthew, Tran, David T, Khatri, Natasha, Godinho, Bruno M D C, Kinberger, Garth A, Montagna, Daniel R, Hirst, Warren D, Guardado, Catherine L, Glajch, Kelly E, Arnold, H Moore, Gallant-Behm, Corrie L, Weihofen, Andreas
Published in Scientific reports (24.01.2024)
Published in Scientific reports (24.01.2024)
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Journal Article
Conjugation of mono and di-GalNAc sugars enhances the potency of antisense oligonucleotides via ASGR mediated delivery to hepatocytes
Kinberger, Garth A., Prakash, Thazha P., Yu, Jinghua, Vasquez, Guillermo, Low, Audrey, Chappell, Alfred, Schmidt, Karsten, Murray, Heather M., Gaus, Hans, Swayze, Eric E., Seth, Punit P.
Published in Bioorganic & medicinal chemistry letters (01.08.2016)
Published in Bioorganic & medicinal chemistry letters (01.08.2016)
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Journal Article
S -Acyl-2-Thioethyl: A Convenient Base-Labile Protecting Group for the Synthesis of siRNAs Containing 5'-Vinylphosphonate
Nikan, Mehran, Li, Wenyu, Kinberger, Garth A, Seth, Punit P, Swayze, Eric E, Prakash, Thazha P
Published in Molecules (Basel, Switzerland) (09.01.2019)
Published in Molecules (Basel, Switzerland) (09.01.2019)
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Journal Article
Solid-phase synthesis of 5′-triantennary N-acetylgalactosamine conjugated antisense oligonucleotides using phosphoramidite chemistry
Prakash, Thazha P., Brad Wan, W., Low, Audrey, Yu, Jinghua, Chappell, Alfred E., Gaus, Hans, Kinberger, Garth A., Østergaard, Michael E., Migawa, Michael T., Swayze, Eric E., Seth, Punit P.
Published in Bioorganic & medicinal chemistry letters (01.10.2015)
Published in Bioorganic & medicinal chemistry letters (01.10.2015)
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Journal Article
A convenient synthesis of 5′-triantennary N-acetyl-galactosamine clusters based on nitromethanetrispropionic acid
Migawa, Michael T., Prakash, Thazha P., Vasquez, Guillermo, Wan, W. Brad, Yu, Jinghua, Kinberger, Garth A., Østergaard, Michael E., Swayze, Eric E., Seth, Punit P.
Published in Bioorganic & medicinal chemistry letters (01.05.2016)
Published in Bioorganic & medicinal chemistry letters (01.05.2016)
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Journal Article
Asialoglycoprotein receptor 1 mediates productive uptake of N-acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes
Tanowitz, Michael, Hettrick, Lisa, Revenko, Alexey, Kinberger, Garth A, Prakash, Thazha P, Seth, Punit P
Published in Nucleic acids research (01.12.2017)
Published in Nucleic acids research (01.12.2017)
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Journal Article
Conjugation of hydrophobic moieties enhances potency of antisense oligonucleotides in the muscle of rodents and non-human primates
Østergaard, Michael E, Jackson, Michaela, Low, Audrey, E. Chappell, Alfred, G. Lee, Richard, Peralta, Rachel Q, Yu, Jinghua, Kinberger, Garth A, Dan, Amy, Carty, Rick, Tanowitz, Michael, Anderson, Patrick, Kim, Tae-Won, Fradkin, Linda, Mullick, Adam E, Murray, Sue, Rigo, Frank, Prakash, Thazha P, Bennett, C Frank, Swayze, Eric E, Gaus, Hans J, Seth, Punit P
Published in Nucleic acids research (09.07.2019)
Published in Nucleic acids research (09.07.2019)
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Journal Article
Hsp90 protein interacts with phosphorothioate oligonucleotides containing hydrophobic 2'-modifications and enhances antisense activity
Liang, Xue-Hai, Shen, Wen, Sun, Hong, Kinberger, Garth A, Prakash, Thazha P, Nichols, Joshua G, Crooke, Stanley T
Published in Nucleic acids research (05.05.2016)
Published in Nucleic acids research (05.05.2016)
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Journal Article
Identification of metabolically stable 5'-phosphate analogs that support single-stranded siRNA activity
Prakash, Thazha P, Lima, Walt F, Murray, Heather M, Li, Wenyu, Kinberger, Garth A, Chappell, Alfred E, Gaus, Hans, Seth, Punit P, Bhat, Balkrishen, Crooke, Stanley T, Swayze, Eric E
Published in Nucleic acids research (31.03.2015)
Published in Nucleic acids research (31.03.2015)
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Journal Article
Synthesis and Biophysical Evaluation of 2′,4′-Constrained 2′O-Methoxyethyl and 2′,4′-Constrained 2′O-Ethyl Nucleic Acid Analogues
Seth, Punit P, Vasquez, Guillermo, Allerson, Charles A, Berdeja, Andres, Gaus, Hans, Kinberger, Garth A, Prakash, Thazha P, Migawa, Michael T, Bhat, Balkrishen, Swayze, Eric E
Published in Journal of organic chemistry (05.03.2010)
Published in Journal of organic chemistry (05.03.2010)
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Journal Article
Evaluation of the effect of 2′-O-methyl, fluoro hexitol, bicyclo and Morpholino nucleic acid modifications on potency of GalNAc conjugated antisense oligonucleotides in mice
Prakash, Thazha P., Yu, Jinghua, Kinberger, Garth A., Low, Audrey, Jackson, Michaela, Rigo, Frank, Swayze, Eric E., Seth, Punit P.
Published in Bioorganic & medicinal chemistry letters (15.12.2018)
Published in Bioorganic & medicinal chemistry letters (15.12.2018)
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Journal Article
Identification of metabolically stable 5΄-phosphate analogs that support single-stranded siRNA activity
Prakash, Thazha P, Lima, Walt F, Murray, Heather M, Li, Wenyu, Kinberger, Garth A, Chappell, Alfred E, Gaus, Hans, Seth, Punit P, Bhat, Balkrishen, Crooke, Stanley T, Swayze, Eric E
Published in Nucleic acids research (20.06.2017)
Published in Nucleic acids research (20.06.2017)
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Journal Article
Collagen Mimetic Dendrimers
Kinberger, Garth A, Cai, Weibo, Goodman, Murray
Published in Journal of the American Chemical Society (25.12.2002)
Published in Journal of the American Chemical Society (25.12.2002)
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Journal Article