The co-crystal structure of Cbl-b and a small-molecule inhibitor reveals the mechanism of Cbl-b inhibition
Kimani, Serah W, Perveen, Sumera, Szewezyk, Magdalena, Zeng, Hong, Dong, Aiping, Li, Fengling, Ghiabi, Pegah, Li, Yanjun, Chau, Irene, Arrowsmith, Cheryl H, Barsyte-Lovejoy, Dalia, Santhakumar, Vijayaratnam, Vedadi, Masoud, Halabelian, Levon
Published in Communications biology (16.12.2023)
Published in Communications biology (16.12.2023)
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Journal Article
A ligand discovery toolbox for the WWE domain family of human E3 ligases
Münzker, Lena, Kimani, Serah W., Fowkes, Milan M., Dong, Aiping, Zheng, Hong, Li, Yanjun, Dasovich, Morgan, Zak, Krzysztof M., Leung, Anthony K. L., Elkins, Jonathan M., Kessler, Dirk, Arrowsmith, Cheryl H., Halabelian, Levon, Böttcher, Jark
Published in Communications biology (24.07.2024)
Published in Communications biology (24.07.2024)
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Journal Article
Discovery of a Novel DCAF1 Ligand Using a Drug–Target Interaction Prediction Model: Generalizing Machine Learning to New Drug Targets
Kimani, Serah W., Owen, Julie, Green, Stuart R., Li, Fengling, Li, Yanjun, Dong, Aiping, Brown, Peter J., Ackloo, Suzanne, Kuter, David, Yang, Cindy, MacAskill, Miranda, MacKinnon, Stephen Scott, Arrowsmith, Cheryl H., Schapira, Matthieu, Shahani, Vijay, Halabelian, Levon
Published in Journal of chemical information and modeling (10.07.2023)
Published in Journal of chemical information and modeling (10.07.2023)
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Journal Article
The mechanism of the amidases: mutating the glutamate adjacent to the catalytic triad inactivates the enzyme due to substrate mispositioning
Weber, Brandon W, Kimani, Serah W, Varsani, Arvind, Cowan, Donald A, Hunter, Roger, Venter, Gerhard A, Gumbart, James C, Sewell, B Trevor
Published in The Journal of biological chemistry (04.10.2013)
Published in The Journal of biological chemistry (04.10.2013)
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Journal Article
The quaternary structure of the amidase from Geobacillus pallidus RAPc8 is revealed by its crystal packing
Agarkar, Vinod B., Kimani, Serah W., Cowan, Donald A., Sayed, Muhammed F.-R., Sewell, B. Trevor
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.12.2006)
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.12.2006)
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Journal Article
The Mechanism of the Amidases
Weber, Brandon W., Kimani, Serah W., Varsani, Arvind, Cowan, Donald A., Hunter, Roger, Venter, Gerhard A., Gumbart, James C., Sewell, B. Trevor
Published in The Journal of biological chemistry (04.10.2013)
Published in The Journal of biological chemistry (04.10.2013)
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Journal Article
A resource to enable chemical biology and drug discovery of WDR Proteins
Arrowsmith, Cheryl H, Ackloo, Suzanne, Li, Fengling, Szewczyk, Magda, Seitova, Almagul, Loppnau, Peter, Zeng, Hong, Ahmad, Shabbir, Beldar, Serap, Bolotokova, Albina, Chau, Irene, Dehghani-Tafti, Saba, Dong, Aiping, Ghiabi, Pegah, Gibson, Elisa, Green, Stuart R, Herasymenko, Oleksandra, Houliston, Scott, Hutchinson, Ashley, Kimani, Serah W, Kutera, Maria, Kwak, Haejin A, Li, Yanjun, Raquel Ac Machado, Perveen, Sumera, Righetto, Germanna L, Shrestha, Suman, Silva, Madhushika, Yadav, Manisha, Yazdi, Aliakbar K, Santhakumar, Vijayaratnam, Edwards, Aled M, Barsyte-Lovejoy, Dalia, Schapira, Matthieu, Brown, Peter J, Halabelian, Levon, Xu, Jin, Feng, Jianwen A, Kearnes, Steven, Thompson, James, Torng, Wen, Gilmer, Justin, Riley, Patrick, Watson, Ian, Arnautova, Yelena A, Baghaie, Aj, Cuozzo, John W, Disch, Jeremy S, Dumas, Antoine, Harms, Nathan, Liu, Jenny, Sigel, Eric A, Goldman, Brian, Kramer, Trevor, Mulhern, Christopher A, Slakman, Belinda L, Underkoffler, Carl, Moritz Von Rechenberg, Centrella, Paolo A, Clark, Matthew A, Marie-Aude Guie, Gullinger, John P, Keefe, Anthony D, Taylor, Rhys D, Zhang, Junyi, Zhang, Ying, Lento, Cristina, Wilson, Derek J, Wolf, Esther, Loup, Joachim, Sintchak, Michael D
Published in bioRxiv (04.03.2024)
Published in bioRxiv (04.03.2024)
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