Asymmetric synthesis and biological evaluation of .beta.-L-(2R,5S)- and .alpha.-L-(2R,5R)-1,3-oxathiolane-pyrimidine and -purine nucleosides as potential anti-HIV agents
Jeong, Lak S, Schinazi, Raymond F, Beach, J. Warren, Kim, Hea O, Nampalli, Satyanarayana, Shanmuganathan, Kirupathevy, Alves, Antonio J, McMillan, Angela, Chu, Chung K, Mathis, Rodney
Published in Journal of medicinal chemistry (01.01.1993)
Published in Journal of medicinal chemistry (01.01.1993)
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Synthesis of enantiomerically pure (2'R,5'S)-(-)-1-(2-hydroxymethyloxathiolan-5-yl)cytosine as a potent antiviral agent against hepatitis B virus (HBV) and human immunodeficiency virus (HIV)
Beach, J. Warren, Jeong, Lak S, Alves, Antonio J, Pohl, Douglas, Kim, Hea O, Chang, Chien Neng, Doong, Shin Lian, Schinazi, Raymond F, Cheng, Yung Chi, Chu, Chung K
Published in Journal of organic chemistry (01.04.1992)
Published in Journal of organic chemistry (01.04.1992)
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Journal Article
L-.beta.-(2S,4S)- and L-.alpha.-(2S,4R)-dioxolanyl nucleosides as potential anti-HIV agents: asymmetric synthesis and structure-activity relationships
Kim, Hea O, Schinazi, Raymond F, Shanmuganathan, Kirupathevy, Jeong, Lak S, Beach, J. Warren, Nampalli, Satyanarayana, Cannon, Deborah L, Chu, Chung K
Published in Journal of medicinal chemistry (01.03.1993)
Published in Journal of medicinal chemistry (01.03.1993)
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A highly stereoselective synthesis of anti-HIV 2',3'-dideoxy- and 2',3'-didehydro-2',3'-dideoxynucleosides
Beach, J. Warren, Kim, Hea O, Jeong, Lak S, Nampalli, Satyanarayana, Islam, Qamrul, Ahn, Soon K, Babu, J. Ramesh, Chu, Chung K
Published in Journal of organic chemistry (01.07.1992)
Published in Journal of organic chemistry (01.07.1992)
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Structure-Activity Relationships of 9-Alkyladenine and Ribose-Modified Adenosine Derivatives at Rat A3 Adenosine Receptors
Jacobson, Kenneth A, Siddiqi, Suhaib M, Olah, Mark E, Ji, Xiao-duo, Melman, Neli, Bellamkonda, Kamala, Meshulam, Yacov, Stiles, Gary L, Kim, Hea O
Published in Journal of medicinal chemistry (01.05.1995)
Published in Journal of medicinal chemistry (01.05.1995)
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Journal Article
Structure-activity relationships of .beta.-D-(2S,5R)- and .alpha.-D-(2S,5S)-1,3-oxathiolanyl nucleosides as potential anti-HIV agents
Jeong, Lak S, Schinazi, Raymond F, Beach, J. Warren, Kim, Hea O, Shanmuganathan, Kirupathevy, Nampalli, Satyanarayana, Chun, Moon W, Chung, Won Keun, Choi, Bo G, Chu, Chung K
Published in Journal of medicinal chemistry (01.09.1993)
Published in Journal of medicinal chemistry (01.09.1993)
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Synthesis of 2-Chloro-N6-Substituted-4′-thioadenosine-5′-N, N-dialkyluronamides as Potent and Selective A3 Adenosine Receptor Antagonists
Choi, Won Jun, Lee, Hyuk Woo, Hou, Xiyan, Kim, Hea OK, Jacobson, Kenneth A., Jeong, Lak Shin
Published in Nucleic Acids Symposium Series (2008)
Published in Nucleic Acids Symposium Series (2008)
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Radiolabeling and efficient synthesis of tritiated 2-chloro-N6-(3-iodobenzyl)adenosine-5′-N-methyluron-amide, a potent, selective A3 adenosine receptor agonist
Kim, H.O., Hawes, C., Towers, P., Jacobson, K.A.
Published in Journal of labelled compounds & radiopharmaceuticals (01.06.1996)
Published in Journal of labelled compounds & radiopharmaceuticals (01.06.1996)
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G protein-dependent activation of phospholipase C by adenosine A3 receptors in rat brain
Abbracchio, M P, Brambilla, R, Ceruti, S, Kim, H O, von Lubitz, D K, Jacobson, K A, Cattabeni, F
Published in Molecular pharmacology (01.12.1995)
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Published in Molecular pharmacology (01.12.1995)
Journal Article
1,3-Dioxolanylpurine nucleosides (2R,4R) and (2R,4S) with selective anti-HIV-1 activity in human lymphocytes
Kim, Hea O., Schinazi, Raymond F., Nampalli, Satyanarayana, Shanmuganathan, Kirupathevy, Cannon, Deborah L., Alves, Antonio J., Jeong, Lak S., Beach, J. Warren, Chu, Chung K.
Published in Journal of medicinal chemistry (1993)
Published in Journal of medicinal chemistry (1993)
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2-Substitution of Adenine Nucleotide Analogues Containing a Bicyclo[3.1.0]hexane Ring System Locked in a Northern Conformation: Enhanced Potency as P2Y1 Receptor Antagonists
Kim, Hak Sung, Ohno, Michihiro, Xu, Bin, Kim, Hea Ok, Choi, Yongseok, Ji, Xiao D, Maddileti, Savitri, Marquez, Victor E, Harden, T. Kendall, Jacobson, Kenneth A
Published in Journal of medicinal chemistry (06.11.2003)
Published in Journal of medicinal chemistry (06.11.2003)
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Activation of Hippocampal Adenosine A 3 Receptors Produces a Desensitization of A 1 Receptor-Mediated Responses in Rat Hippocampus
Dunwiddie, Thomas V., Diao, Lihong, Kim, Hea O., Jiang, Ji-Long, Jacobson, Kenneth A.
Published in The Journal of neuroscience (15.01.1997)
Published in The Journal of neuroscience (15.01.1997)
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POTENT ANTI-HIV AND ANTI-HBV ACTIVITIES OF (-)-L-BETA-DIOXOLANE-C AND (+)-L-BETA-DIOXOLANE-T AND THEIR ASYMMETRIC SYNTHESES
KIM, HO, SHANMUGANATHAN, K, ALVES, AJ, JEONG, LS, BEACH, JW, SCHINAZI, RF, CHANG, CN, CHENG, YC, CHU, CK
Published in Tetrahedron letters (10.11.1992)
Published in Tetrahedron letters (10.11.1992)
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Induction of Apoptosis in HL-60 Human Promyelocytic Leukemia Cells by Adenosine A3Receptor Agonists: Volume219,Number 3 (1996), pages 904–910
Kohno, Yutaka, Sei, Yoshitatsu, Koshiba, Masahiro, Kim, Hea O., Jacobson, Kenneth A.
Published in Biochemical and biophysical research communications (25.04.1996)
Published in Biochemical and biophysical research communications (25.04.1996)
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