Loss of Complement Factor H impairs antioxidant capacity and energy metabolism of human RPE cells
Armento, Angela, Honisch, Sabina, Panagiotakopoulou, Vasiliki, Sonntag, Inga, Jacob, Anke, Bolz, Sylvia, Kilger, Ellen, Deleidi, Michela, Clark, Simon, Ueffing, Marius
Published in Scientific reports (25.06.2020)
Published in Scientific reports (25.06.2020)
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CFH Loss in Human RPE Cells Leads to Inflammation and Complement System Dysregulation via the NF-κB Pathway
Armento, Angela, Schmidt, Tiziana L., Sonntag, Inga, Merle, David A., Jarboui, Mohamed Ali, Kilger, Ellen, Clark, Simon J., Ueffing, Marius
Published in International journal of molecular sciences (13.08.2021)
Published in International journal of molecular sciences (13.08.2021)
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Mutant dominant-negative rhodopsin ∆I256 causes protein aggregates degraded via ERAD and prevents normal rhodopsin from proper membrane trafficking
Cao, Bowen, Dahlen, Johanna Valentina, Sen, Merve, Beyer, Tina, Leonhard, Tobias, Kilger, Ellen, Arango-Gonzalez, Blanca, Ueffing, Marius
Published in Frontiers in molecular biosciences (17.05.2024)
Published in Frontiers in molecular biosciences (17.05.2024)
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Journal Article
mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells
Merle, David A, Provenzano, Francesca, Jarboui, Mohamed Ali, Kilger, Ellen, Clark, Simon J, Deleidi, Michela, Armento, Angela, Ueffing, Marius
Published in Antioxidants (03.12.2021)
Published in Antioxidants (03.12.2021)
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Journal Article
Complement Factor H Loss in RPE Cells Causes Retinal Degeneration in a Human RPE-Porcine Retinal Explant Co-Culture Model
Armento, Angela, Murali, Aparna, Marzi, Julia, Almansa-Garcia, Ana C, Arango-Gonzalez, Blanca, Kilger, Ellen, Clark, Simon J, Schenke-Layland, Katja, Ramlogan-Steel, Charmaine A, Steel, Jason C, Ueffing, Marius
Published in Biomolecules (Basel, Switzerland) (03.11.2021)
Published in Biomolecules (Basel, Switzerland) (03.11.2021)
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Journal Article
Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease
Coomaraswamy, Janaky, Kilger, Ellen, Wölfing, Heidrun, Schäfer, Claudia, Kaeser, Stephan A, Wegenast-Braun, Bettina M, Hefendehl, Jasmin K, Wolburg, Hartwig, Mazzella, Matthew, Ghiso, Jorge, Goedert, Michel, Akiyama, Haruhiko, Garcia-Sierra, Francisco, Wolfer, David P, Mathews, Paul M, Jucker, Mathias
Published in Proceedings of the National Academy of Sciences - PNAS (27.04.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (27.04.2010)
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Journal Article
Latent membrane protein 1 of Epstein-Barr virus coordinately regulates proliferation with control of apoptosis
DIRMEIER, Ulrike, HOFFMANN, Reinhard, KILGER, Ellen, SCHULTHEISS, Ute, BRISENO, Cinthia, GIRES, Olivier, KIESER, Arnd, EICK, Dirk, SUGDEN, Bill, HAMMERSCHMIDT, Wolfgang
Published in Oncogene (03.03.2005)
Published in Oncogene (03.03.2005)
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Exogenous Induction of Cerebral ß-Amyloidogenesis Is Governed by Agent and Host
Meyer-Luehmann, Melanie, Coomaraswamy, Janaky, Bolmont, Tristan, Kaeser, Stephan, Schaefer, Claudia, Kilger, Ellen, Neuenschwander, Anton, Abramowski, Dorothee, Frey, Peter, Jaton, Anneliese L., Vigouret, Jean-Marie, Paganetti, Paolo, Walsh, Dominic M., Mathews, Paul M., Ghiso, Jorge, Staufenbiel, Matthias, Walker, Lary C., Jucker, Mathias
Published in Science (American Association for the Advancement of Science) (22.09.2006)
Published in Science (American Association for the Advancement of Science) (22.09.2006)
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Journal Article
Exogenous Induction of Cerebral β-Amyloidogenesis Is Governed by Agent and Host
Meyer-Luehmann, Melanie, Coomaraswamy, Janaky, Bolmont, Tristan, Kaeser, Stephan, Schaefer, Claudia, Kilger, Ellen, Neuenschwander, Anton, Abramowski, Dorothee, Frey, Peter, Jaton, Anneliese L, Vigouret, Jean-Marie, Paganetti, Paolo, Walsh, Dominic M, Mathews, Paul M, Ghiso, Jorge, Staufenbiel, Matthias, Walker, Lary C, Jucker, Mathias
Published in Science (American Association for the Advancement of Science) (22.09.2006)
Published in Science (American Association for the Advancement of Science) (22.09.2006)
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Journal Article
Cystatin C modulates cerebral β-amyloidosis
Herzig, Martin C, Grubb, Anders, Kaeser, Stephan A, Kilger, Ellen, Staufenbiel, Matthias, Jucker, Mathias, Selenica, Maj-Linda, Winkler, David T, Coomaraswamy, Janaky, Levy, Efrat
Published in Nature genetics (01.12.2007)
Published in Nature genetics (01.12.2007)
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BRI2 Protein Regulates β-Amyloid Degradation by Increasing Levels of Secreted Insulin-degrading Enzyme (IDE)
Kilger, Ellen, Buehler, Anika, Woelfing, Heidrun, Kumar, Sathish, Kaeser, Stephan A., Nagarathinam, Amudha, Walter, Jochen, Jucker, Mathias, Coomaraswamy, Janaky
Published in The Journal of biological chemistry (28.10.2011)
Published in The Journal of biological chemistry (28.10.2011)
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Journal Article
Development of a Genotype Assay for Age-Related Macular Degeneration
de Breuk, Anita, Acar, Ilhan E., Kersten, Eveline, Schijvenaars, Mascha M.V.A.P., Colijn, Johanna M., Haer-Wigman, Lonneke, Bakker, Bjorn, de Jong, Sarah, Meester-Smoor, Magda A., Verzijden, Timo, Missotten, Tom O.A.R., Monés, Jordi, Biarnés, Marc, Pauleikhoff, Daniel, Hense, Hans W., Silva, Rufino, Nunes, Sandrina, Melo, Joana B., Fauser, Sascha, Hoyng, Carel B., Ueffing, Marius, Coenen, Marieke J.H., Klaver, Caroline C.W., den Hollander, Anneke I., Ajana, Soufiane, Cougnard-Grégoire, Audrey, Delcourt, Cécile, Merle, Bénédicte M.J., Arango-Gonzalez, Blanca, Dammeier, Sascha, Diether, Sigrid, Honisch, Sabina, Kilger, Ellen, Ueffing, Marius, Endermann, Tanja, Zumbansen, Markus, Badura, Franz, De la Cerda, Berta, Biarnés, Marc, Borrell, Anna, Ferraro, Lucia L., Garcia, Míriam, Monés, Jordi, Rodríguez, Eduardo, Colijn, Johanna M., Ikram, A., Klaver, Caroline C.W., Meester-Smoor, Magda, Verzijden, Timo, Vingerling, Johannes, den Hollander, Anneke I., Heesterbeek, Thomas J., Kersten, Eveline, de Jong, Eiko K., Acar, I. Erkin, de Breuk, Anita, Emri, Eszter, Lengyel, Imre, Langen, Hanno, Nogoceke, Everson, Peto, Tunde, Luthert, Phil, Pool, Frances M.
Published in Ophthalmology (Rochester, Minn.) (01.11.2021)
Published in Ophthalmology (Rochester, Minn.) (01.11.2021)
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Integrating Metabolomics, Genomics, and Disease Pathways in Age-Related Macular Degeneration
Acar, İlhan E., Lores-Motta, Laura, Colijn, Johanna M., Meester-Smoor, Magda A., Verzijden, Timo, Cougnard-Gregoire, Audrey, Ajana, Soufiane, Merle, Benedicte M.J., de Breuk, Anita, Heesterbeek, Thomas J., van den Akker, Erik, Daha, Mohamed R., Claes, Birte, Pauleikhoff, Daniel, Hense, Hans-Werner, van Duijn, Cornelia M., Fauser, Sascha, Hoyng, Carel B., Delcourt, Cécile, Klaver, Caroline C.W., Galesloot, Tessel E., den Hollander, Anneke I., Arango-Gonzalez, Blanca, Armento, Angela, Badura, Franz, Bhatia, Vaibhav, Bhattacharya, Shomi S., Biarnés, Marc, Borrell, Anna, Calado, Sofia M., Dammeier, Sascha, Cerda, Berta De la, Diaz-Corrales, Francisco J., Diether, Sigrid, Emri, Eszter, Endermann, Tanja, Ferraro, Lucia L., Garcia, Míriam, Honisch, Sabina, Kilger, Ellen, Kortvely, Elod, Lastrucci, Claire, Langen, Hanno, Lengyel, Imre, Luthert, Phil, Monés, Jordi, Nogoceke, Everson, Peto, Tunde, Pool, Frances M., Rodriguez-Bocanegra, Eduardo, Serrano, Luis, Sousa, Jose, Thee, Eric, Ueffing, Marius, Ulrich Bartz-Schmidt, Karl U., Zumbansen, Markus
Published in Ophthalmology (Rochester, Minn.) (01.12.2020)
Published in Ophthalmology (Rochester, Minn.) (01.12.2020)
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Gleevec increases levels of the amyloid precursor protein intracellular domain and of the amyloid-beta degrading enzyme neprilysin
Eisele, Yvonne S, Baumann, Matthias, Klebl, Bert, Nordhammer, Christina, Jucker, Mathias, Kilger, Ellen
Published in Molecular biology of the cell (01.09.2007)
Published in Molecular biology of the cell (01.09.2007)
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A Multi-Omics Approach Identifies Key Regulatory Pathways Induced by Long-Term Zinc Supplementation in Human Primary Retinal Pigment Epithelium
Emri, Eszter, Kortvely, Elod, Dammeier, Sascha, Klose, Franziska, Simpson, David, Consortium, Eye-Risk, Den Hollander, Anneke I, Ueffing, Marius, Lengyel, Imre
Published in Nutrients (06.10.2020)
Published in Nutrients (06.10.2020)
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Metabolomics and Age-Related Macular Degeneration
Brown, Connor N, Green, Brian D, Thompson, Richard B, den Hollander, Anneke I, Lengyel, Imre
Published in Metabolites (27.12.2018)
Published in Metabolites (27.12.2018)
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Journal Article
Mediterranean Diet and Incidence of Advanced Age-Related Macular Degeneration
Merle, Bénédicte M.J., Colijn, Johanna M., Cougnard-Grégoire, Audrey, de Koning-Backus, Alexandra P.M., Delyfer, Marie-Noëlle, Kiefte-de Jong, Jessica C., Meester-Smoor, Magda, Féart, Catherine, Verzijden, Timo, Samieri, Cécilia, Franco, Oscar H., Korobelnik, Jean-François, Klaver, Caroline C.W., Delcourt, Cécile, Ajana, Soufiane, Arango-Gonzalez, Blanca, Armento, Angela, Arndt, Verena, Bhatia, Vaibhav, Bhattacharya, Shomi S., Biarnés, Marc, Borrell, Anna, Bühren, Sebastian, Calado, Sofia M., Colijn, Johanna M., Cougnard-Grégoire, Audrey, Dammeier, Sascha, de Jong, Eiko K., De la Cerda, Berta, Delcourt, Cécile, den Hollander, Anneke I., Diaz-Corrales, Francisco J., Diether, Sigrid, Emri, Eszter, Endermann, Tanja, Ferraro, Lucia L., Garcia, Míriam, Heesterbeek, Thomas J., Honisch, Sabina, Hoyng, Carel B., Kersten, Eveline, Kilger, Ellen, Klaver, Caroline C.W., Langen, Hanno, Lengyel, Imre, Luthert, Phil, Maugeais, Cyrille, Meester-Smoor, Magda, Merle, Bénédicte M.J., Monés, Jordi, Nogoceke, Everson, Peto, Tunde, Pool, Frances M., Rodríguez, Eduardo, Ueffing, Marius, Ulrich Bartz-Schmidt, Karl U., van Leeuwen, Elisabeth M., Verzijden, Timo, Zumbansen, Markus, Vasiliev, Vassil
Published in Ophthalmology (Rochester, Minn.) (01.03.2019)
Published in Ophthalmology (Rochester, Minn.) (01.03.2019)
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Journal Article
Latent membrane protein 1 of Epstein-Barr virus interacts with JAK3 and activates STAT proteins
Gires, Olivier, Kohlhuber, Franz, Kilger, Ellen, Baumann, Matthias, Kieser, Arnd, Kaiser, Christian, Zeidler, Reinhard, Scheffer, Beatrix, Ueffing, Marius, Hammerschmidt, Wolfgang
Published in The EMBO journal (01.06.1999)
Published in The EMBO journal (01.06.1999)
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