Discovery of Apararenone (MT-3995) as a Highly Selective, Potent, and Novel Nonsteroidal Mineralocorticoid Receptor Antagonist
Iijima, Toru, Katoh, Makoto, Takedomi, Kei, Yamamoto, Yasuo, Akatsuka, Hidenori, Shirata, Naritoshi, Nishi, Akito, Takakuwa, Misae, Watanabe, Yoshinori, Munakata, Hitomi, Koyama, Naomi, Ikeda, Tomoko, Iguchi, Taku, Kato, Harutoshi, Kikkawa, Kohei, Kawaguchi, Takayuki
Published in Journal of medicinal chemistry (23.06.2022)
Published in Journal of medicinal chemistry (23.06.2022)
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Avanafil, a Potent and Highly Selective Phosphodiesterase-5 Inhibitor for Erectile Dysfunction
Kotera, Jun, Mochida, Hideki, Inoue, Hirotaka, Noto, Tsunehisa, Fujishige, Kotomi, Sasaki, Takashi, Kobayashi, Tamaki, Kojima, Koki, Yee, Shiyin, Yamada, Yasuhiro, Kikkawa, Kohei, Omori, Kenji
Published in The Journal of urology (01.08.2012)
Published in The Journal of urology (01.08.2012)
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Selectivity of avanafil, a PDE5 inhibitor for the treatment of erectile dysfunction: implications for clinical safety and improved tolerability
Wang, Run, Burnett, Arthur L, Heller, Warren H, Omori, Kenji, Kotera, Jun, Kikkawa, Kohei, Yee, Shiyin, Day, Wesley W, DiDonato, Karen, Peterson, Craig A
Published in Journal of sexual medicine (01.08.2012)
Published in Journal of sexual medicine (01.08.2012)
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The discovery of avanafil for the treatment of erectile dysfunction: A novel pyrimidine-5-carboxamide derivative as a potent and highly selective phosphodiesterase 5 inhibitor
Sakamoto, Toshiaki, Koga, Yuichi, Hikota, Masataka, Matsuki, Kenji, Murakami, Michino, Kikkawa, Kohei, Fujishige, Kotomi, Kotera, Jun, Omori, Kenji, Morimoto, Hiroshi, Yamada, Koichiro
Published in Bioorganic & medicinal chemistry letters (01.12.2014)
Published in Bioorganic & medicinal chemistry letters (01.12.2014)
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Ultrarapid, Highly Efficient Viral Gene Transfer to the Heart
Donahue, J. Kevin, Kikkawa, Kohei, Johns, David C., Marban, Eduardo, Lawrence, John H.
Published in Proceedings of the National Academy of Sciences - PNAS (29.04.1997)
Published in Proceedings of the National Academy of Sciences - PNAS (29.04.1997)
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Novel, Potent, and Selective Phosphodiesterase 5 Inhibitors: Synthesis and Biological Activities of a Series of 4-Aryl-1-isoquinolinone Derivatives
Ukita, Tatsuzo, Nakamura, Yoshinori, Kubo, Akira, Yamamoto, Yasuo, Moritani, Yasunori, Saruta, Kunio, Higashijima, Takanori, Kotera, Jun, Takagi, Michino, Kikkawa, Kohei, Omori, Kenji
Published in Journal of medicinal chemistry (21.06.2001)
Published in Journal of medicinal chemistry (21.06.2001)
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Thiourea as a “Polar Hydrophobic” Hydrogen-Bonding Motif: Application to Highly Durable All-Underwater Adhesion
Kikkawa, Kohei, Sumiya, Yosuke, Okazawa, Kazuki, Yoshizawa, Kazunari, Itoh, Yoshimitsu, Aida, Takuzo
Published in Journal of the American Chemical Society (31.07.2024)
Published in Journal of the American Chemical Society (31.07.2024)
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Acute and Chronic Effects of T-1032, a Novel Selective Phosphodiesterase Type 5 Inhibitor, on Monocrotaline-Induced Pulmonary Hypertension in Rats
Inoue, Hirotaka, Yano, Koji, Noto, Tsunehisa, Takagi, Michino, Ikeo, Tomihiro, Kikkawa, Kohei
Published in Biological & pharmaceutical bulletin (01.11.2002)
Published in Biological & pharmaceutical bulletin (01.11.2002)
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Inhibitory Effects of TA-993, a New 1,5-Benzothiazepine Derivative, on Platelet Aggregation
Odawara, Akio, Kikkawa, Kohei, Katoh, Makoto, Toryu, Hiromi, Shimazaki, Tamotu, Sasaki, Yasuhiko
Published in Circulation research (01.04.1996)
Published in Circulation research (01.04.1996)
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Avanafil, a Highly Selective Phosphodiesterase Type 5 Inhibitor for Erectile Dysfunction, Shows Good Safety Profiles for Retinal Function and Hemodynamics in Anesthetized Dogs
Mochida, Hideki, Yano, Koji, Inoue, Hirotaka, Yee, Shiyin, Noto, Tsunehisa, Kikkawa, Kohei
Published in The Journal of urology (01.08.2013)
Published in The Journal of urology (01.08.2013)
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Design and synthesis of novel 5-(3,4,5-trimethoxybenzoyl)-4-aminopyrimidine derivatives as potent and selective phosphodiesterase 5 inhibitors: Scaffold hopping using a pseudo-ring by intramolecular hydrogen bond formation
Sakamoto, Toshiaki, Koga, Yuichi, Hikota, Masataka, Matsuki, Kenji, Murakami, Michino, Kikkawa, Kohei, Fujishige, Kotomi, Kotera, Jun, Omori, Kenji, Morimoto, Hiroshi, Yamada, Koichiro
Published in Bioorganic & medicinal chemistry letters (15.11.2014)
Published in Bioorganic & medicinal chemistry letters (15.11.2014)
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