The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts
Friščić, Jasna, Böttcher, Martin, Reinwald, Christiane, Bruns, Heiko, Wirth, Benjamin, Popp, Samantha-Josefine, Walker, Kellie Irene, Ackermann, Jochen A., Chen, Xi, Turner, Jason, Zhu, Honglin, Seyler, Lisa, Euler, Maximilien, Kirchner, Philipp, Krüger, René, Ekici, Arif B., Major, Triin, Aust, Oliver, Weidner, Daniela, Fischer, Anita, Andes, Fabian T., Stanojevic, Zeljka, Trajkovic, Vladimir, Herrmann, Martin, Korb-Pap, Adelheid, Wank, Isabel, Hess, Andreas, Winter, Johnathan, Wixler, Viktor, Distler, Jörg, Steiner, Günter, Kiener, Hans P., Frey, Benjamin, Kling, Lasse, Raza, Karim, Frey, Silke, Kleyer, Arnd, Bäuerle, Tobias, Hughes, Timothy R., Grüneboom, Anika, Steffen, Ulrike, Krönke, Gerhard, Croft, Adam P., Filer, Andrew, Köhl, Jörg, Klein, Kerstin, Buckley, Christopher D., Schett, Georg, Mougiakakos, Dimitrios, Hoffmann, Markus H.
Published in Immunity (Cambridge, Mass.) (11.05.2021)
Published in Immunity (Cambridge, Mass.) (11.05.2021)
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PU.1 controls fibroblast polarization and tissue fibrosis
Wohlfahrt, Thomas, Rauber, Simon, Uebe, Steffen, Luber, Markus, Soare, Alina, Ekici, Arif, Weber, Stefanie, Matei, Alexandru-Emil, Chen, Chih-Wei, Maier, Christiane, Karouzakis, Emmanuel, Kiener, Hans P., Pachera, Elena, Dees, Clara, Beyer, Christian, Daniel, Christoph, Gelse, Kolja, Kremer, Andreas E., Naschberger, Elisabeth, Stürzl, Michael, Butter, Falk, Sticherling, Michael, Finotto, Susetta, Kreuter, Alexander, Kaplan, Mark H., Jüngel, Astrid, Gay, Steffen, Nutt, Stephen L., Boykin, David W., Poon, Gregory M. K., Distler, Oliver, Schett, Georg, Distler, Jörg H. W., Ramming, Andreas
Published in Nature (London) (01.02.2019)
Published in Nature (London) (01.02.2019)
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Focal adhesion protein Lasp1 links the Arp2/3 complex to adherens junctions and promotes motility of arthritic fibroblast-like synoviocytes
Beckmann, Denise, Krause, Annika, Hansen, Uwe, Kiener, Hans P, Karonitsch, Thomas, Blüml, Stephan, Kremerskothen, Joachim, Pavenstädt, Hermann, Pap, Thomas, Korb-Pap, Adelheid
Published in Annals of the rheumatic diseases (01.06.2024)
Published in Annals of the rheumatic diseases (01.06.2024)
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Establishment of a human three-dimensional chip-based chondro-synovial coculture joint model for reciprocal cross talk studies in arthritis research
Rothbauer, Mario, Byrne, Ruth A, Schobesberger, Silvia, Olmos Calvo, Isabel, Fischer, Anita, Reihs, Eva I, Spitz, Sarah, Bachmann, Barbara, Sevelda, Florian, Holinka, Johannes, Holnthoner, Wolfgang, Redl, Heinz, Toegel, Stefan, Windhager, Reinhard, Kiener, Hans P, Ertl, Peter
Published in Lab on a chip (26.10.2021)
Published in Lab on a chip (26.10.2021)
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IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes
Bonelli, Michael, Dalwigk, Karolina, Platzer, Alexander, Isabel Olmos Calvo, Hayer, Silvia, Niederreiter, Birgit, Holinka, Johannes, Sevelda, Florian, Pap, Thomas, Steiner, Günter, Superti-Furga, Giulio, Smolen, Josef S, Kiener, Hans P, Karonitsch, Thomas
Published in Experimental & molecular medicine (01.07.2019)
Published in Experimental & molecular medicine (01.07.2019)
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Monitoring tissue-level remodelling during inflammatory arthritis using a three-dimensional synovium-on-a-chip with non-invasive light scattering biosensing
Rothbauer, Mario, Höll, Gregor, Eilenberger, Christoph, Kratz, Sebastian R. A, Farooq, Bilal, Schuller, Patrick, Olmos Calvo, Isabel, Byrne, Ruth A, Meyer, Brigitte, Niederreiter, Birgit, Küpcü, Seta, Sevelda, Florian, Holinka, Johannes, Hayden, Oliver, Tedde, Sandro F, Kiener, Hans P, Ertl, Peter
Published in Lab on a chip (21.04.2020)
Published in Lab on a chip (21.04.2020)
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Amino Acids Fueling Fibroblast‐Like Synoviocyte Activation and Arthritis By Regulating Chemokine Expression and Leukocyte Migration
Karonitsch, Thomas, Saferding, Victoria, Kieler, Markus, Dalwigk, Karolina, Tosevska, Anela, Heller, Gerwin, Dellinger, Mirjam, Niederreiter, Birgit, Kartnig, Felix, Steiner, Carl W., Georgel, Philippe, Kiener, Hans P., Smolen, Josef S., Korb‐Pap, Adelheid, Bonelli, Michael, Aletaha, Daniel, Blüml, Stephan
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.04.2024)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.04.2024)
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Cytokine-directed cellular cross-talk imprints synovial pathotypes in rheumatoid arthritis
Kugler, Maximilian, Dellinger, Mirjam, Kartnig, Felix, Müller, Lena, Preglej, Teresa, Heinz, Leonhard X, Simader, Elisabeth, Göschl, Lisa, Puchner, Stephan E, Weiss, Sebastian, Shaw, Lisa E, Farlik, Matthias, Weninger, Wolfgang, Superti-Furga, Giulio, Smolen, Josef S, Steiner, Guenter, Aletaha, Daniel, Kiener, Hans P, Lewis, Myles J, Pitzalis, Costantino, Tosevska, Anela, Karonitsch, Thomas, Bonelli, Michael
Published in Annals of the rheumatic diseases (01.09.2023)
Published in Annals of the rheumatic diseases (01.09.2023)
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Targeted inhibition of Janus kinases abates interfon gamma-induced invasive behaviour of fibroblast-like synoviocytes
Karonitsch, Thomas, Beckmann, Denise, Dalwigk, Karolina, Niederreiter, Birgit, Studenic, Paul, Byrne, Ruth A, Holinka, Johannes, Sevelda, Florian, Korb-Pap, Adelheid, Steiner, Günter, Smolen, Josef S, Pap, Thomas, Kiener, Hans P
Published in Rheumatology (Oxford, England) (01.03.2018)
Published in Rheumatology (Oxford, England) (01.03.2018)
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Cadherin-11 in Synovial Lining Formation and Pathology in Arthritis
Lee, David M, Kiener, Hans P, Agarwal, Sandeep K, Noss, Erika H, Watts, Gerald F.M, Chisaka, Osamu, Takeichi, Masatoshi, Brenner, Michael B
Published in Science (American Association for the Advancement of Science) (16.02.2007)
Published in Science (American Association for the Advancement of Science) (16.02.2007)
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IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes: JAKinibs suppress the interferon response in RA-FLSs
Bonelli, Michael, Dalwigk, Karolina, Platzer, Alexander, Olmos Calvo, Isabel, Hayer, Silvia, Niederreiter, Birgit, Holinka, Johannes, Sevelda, Florian, Pap, Thomas, Steiner, Günter, Superti-Furga, Giulio, Smolen, Josef S., Kiener, Hans P., Karonitsch, Thomas
Published in Experimental & molecular medicine (08.07.2019)
Published in Experimental & molecular medicine (08.07.2019)
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mTOR Senses Environmental Cues to Shape the Fibroblast-like Synoviocyte Response to Inflammation
Karonitsch, Thomas, Kandasamy, Richard K., Kartnig, Felix, Herdy, Barbara, Dalwigk, Karolina, Niederreiter, Birgit, Holinka, Johannes, Sevelda, Florian, Windhager, Reinhard, Bilban, Martin, Weichhart, Thomas, Säemann, Marcus, Pap, Thomas, Steiner, Günter, Smolen, Josef S., Kiener, Hans P., Superti-Furga, Giulio
Published in Cell reports (Cambridge) (15.05.2018)
Published in Cell reports (Cambridge) (15.05.2018)
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Unmet need in rheumatology: reports from the Advances in Targeted Therapies meeting, 2023
Winthrop, Kevin L, Mease, Philip, Kerschbaumer, Andreas, Voll, Reinhard E, Breedveld, Ferdinand C, Smolen, Josef S, Gottenberg, Jacques-Eric, Baraliakos, Xenofon, Kiener, Hans P, Aletaha, Daniel, Isaacs, John D, Buch, Maya H, Crow, Mary K, Kay, Jonathan, Crofford, Leslie, van Vollenhoven, Ronald F, Ospelt, Caroline, Siebert, Stefan, Kloppenburg, Margreet, McInnes, Iain B, Huizinga, Tom WJ, Gravallese, Ellen M
Published in Annals of the rheumatic diseases (01.04.2024)
Published in Annals of the rheumatic diseases (01.04.2024)
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Impact of muscle biopsy on the clinical decision-making process in patients with suspected idiopathic inflammatory myopathy
Kastrati, Kastriot, Nakhost Lotfi, Nasim, Tawfik, Marwa G., Gelpi, Ellen, Hametner, Simon, Höftberger, Romana, Zimprich, Fritz, Cetin, Hakan, Lindeck-Pozza, Elisabeth, Heil, Peter Maximilian, Kiener, Hans P., Heinz, Leonhard X., Mrak, Daniel, Aletaha, Daniel, Bonelli, Michael, Radner, Helga
Published in Journal of autoimmunity (01.04.2024)
Published in Journal of autoimmunity (01.04.2024)
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Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis
Beckmann, Denise, Römer-Hillmann, Anja, Krause, Annika, Hansen, Uwe, Wehmeyer, Corinna, Intemann, Johanna, de Gorter, David J. J., Dankbar, Berno, Hillen, Jan, Heitzmann, Marianne, Begemann, Isabell, Galic, Milos, Weinhage, Toni, Foell, Dirk, Ai, Rizi, Kremerskothen, Joachim, Kiener, Hans P., Müller, Sylvia, Kamradt, Thomas, Schröder, Christopher, Leitão, Elsa, Horsthemke, Bernhard, Rosenstiel, Philip, Nordström, Karl, Gasparoni, Gilles, Gasparoni, Nina, Walter, Jörn, Li, Na, Yang, Xinyi, Chung, Ho-Ryun, Pavenstädt, Hermann, Lindemann, Nico, Schnittler, Hans J., Wang, Wei, Firestein, Gary S., Pap, Thomas, Korb-Pap, Adelheid
Published in Nature communications (15.06.2021)
Published in Nature communications (15.06.2021)
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MicroRNA-146a governs fibroblast activation and joint pathology in arthritis
Saferding, Victoria, Puchner, Antonia, Goncalves-Alves, Eliana, Hofmann, Melanie, Bonelli, Michael, Brunner, Julia S., Sahin, Emine, Niederreiter, Birgit, Hayer, Silvia, Kiener, Hans P., Einwallner, Elisa, Nehmar, Ramzi, Carapito, Raphael, Georgel, Philippe, Koenders, Marije I., Boldin, Mark, Schabbauer, Gernot, Kurowska-Stolarska, Mariola, Steiner, Günter, Smolen, Josef S., Redlich, Kurt, Blüml, Stephan
Published in Journal of autoimmunity (01.08.2017)
Published in Journal of autoimmunity (01.08.2017)
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FOXO3 is involved in the tumor necrosis factor-driven inflammatory response in fibroblast-like synoviocytes
Brandstetter, Bernhard, Dalwigk, Karolina, Platzer, Alexander, Niederreiter, Birgit, Kartnig, Felix, Fischer, Anita, Vladimer, Gregory I., Byrne, Ruth A., Sevelda, Florian, Holinka, Johannes, Pap, Thomas, Steiner, Günter, Superti-Furga, Giulio, Smolen, Josef S., Kiener, Hans P., Karonitsch, Thomas
Published in Laboratory investigation (01.05.2019)
Published in Laboratory investigation (01.05.2019)
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The RNA‐binding protein HuR/ELAVL1 regulates IFN‐β mRNA abundance and the type I IFN response
Herdy, Barbara, Karonitsch, Thomas, Vladimer, Gregory I., Tan, Chris S.H., Stukalov, Alexey, Trefzer, Claudia, Bigenzahn, Johannes W., Theil, Tamara, Holinka, Johannes, Kiener, Hans P., Colinge, Jacques, Bennett, Keiryn L, Superti‐Furga, Giulio
Published in European journal of immunology (01.05.2015)
Published in European journal of immunology (01.05.2015)
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CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis
Karpus, Olga N, Kiener, Hans P, Niederreiter, Birgit, Yilmaz-Elis, A Seda, van der Kaa, Jos, Ramaglia, Valeria, Arens, Ramon, Smolen, Josef S, Botto, Marina, Tak, Paul P, Verbeek, J Sjef, Hamann, Jörg
Published in Arthritis research & therapy (17.01.2015)
Published in Arthritis research & therapy (17.01.2015)
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