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Effect of age on pharmacokinetics, efficacy, and safety of galcanezumab treatment in adult patients with migraine: results from six phase 2 and phase 3 randomized clinical trials
Stauffer, Virginia L., Turner, Ira, Kemmer, Phebe, Kielbasa, William, Day, Kathleen, Port, Martha, Quinlan, Tonya, Camporeale, Angelo
Published in Journal of headache and pain (23.06.2020)
Published in Journal of headache and pain (23.06.2020)
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Neurokinin 1 Receptor Antagonism as a Possible Therapy for Alcoholism
George, David T, Gilman, Jodi, Hersh, Jacqueline, Thorsell, Annika, Herion, David, Geyer, Christopher, Peng, Xiaomei, Kielbasa, William, Rawlings, Robert, Brandt, John E, Gehlert, Donald R, Tauscher, Johannes T, Hunt, Stephen P, Hommer, Daniel, Heilig, Markus
Published in Science (American Association for the Advancement of Science) (14.03.2008)
Published in Science (American Association for the Advancement of Science) (14.03.2008)
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Discovery and clinical translation of ceperognastat, an O‐GlcNAcase (OGA) inhibitor, for the treatment of Alzheimer's disease
Kielbasa, William, Goldsmith, Paul, Donnelly, Kevin B., Nuthall, Hugh N., Shcherbinin, Sergey, Fleisher, Adam S., Hendle, Jörg, DuBois, Susan L., Lowe, Stephen L., Zhang, Feiyu Fred, Woerly, Eric M., Dreyfus, Nicolas J.‐F., Evans, David, Gilmore, Jeremy, Mancini, Michele, Constantinescu, Cristian C., Gunn, Roger N., Russell, David S., Collins, Emily C., Brys, Miroslaw, Hutton, Michael L., Mergott, Dustin J.
Published in Alzheimer's & dementia : translational research & clinical interventions (01.10.2024)
Published in Alzheimer's & dementia : translational research & clinical interventions (01.10.2024)
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Atomoxetine occupies the norepinephrine transporter in a dose-dependent fashion: a PET study in nonhuman primate brain using (S,S)-[18F]FMeNER-D2
Seneca, Nicholas, Gulyás, Balázs, Varrone, Andrea, Schou, Magnus, Airaksinen, Anu, Tauscher, Johannes, Vandenhende, Francois, Kielbasa, William, Farde, Lars, Innis, Robert B., Halldin, Christer
Published in Psychopharmacologia (01.09.2006)
Published in Psychopharmacologia (01.09.2006)
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A pharmacokinetic/pharmacodynamic investigation: Assessment of edivoxetine and atomoxetine on systemic and central 3,4-dihydroxyphenylglycol, a biochemical marker for norepinephrine transporter inhibition
Kielbasa, William, Pan, Alan, Pereira, Alvaro
Published in European neuropsychopharmacology (01.03.2015)
Published in European neuropsychopharmacology (01.03.2015)
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The dopamine D1 receptor positive allosteric modulator mevidalen (LY3154207) enhances wakefulness in the humanized D1 mouse and in sleep deprived healthy volunteers
McCarthy, Andrew P., Svensson, Kjell A., Shanks, Elaine, Brittain, Claire, Eastwood, Brian J., Kielbasa, William, Biglan, Kevin M., Wafford, Keith A.
Published in The Journal of pharmacology and experimental therapeutics (01.03.2022)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2022)
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The Dopamine D1 Receptor Positive Allosteric Modulator Mevidalen (LY3154207) Enhances Wakefulness in the Humanized D1 Mouse and in Sleep-Deprived Healthy Male Volunteers
McCarthy, Andrew P., Svensson, Kjell A., Shanks, Elaine, Brittain, Claire, Eastwood, Brian J., Kielbasa, William, Biglan, Kevin M., Wafford, Keith A.
Published in The Journal of pharmacology and experimental therapeutics (01.03.2022)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2022)
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Safety of galcanezumab in patients with episodic migraine: A randomized placebo-controlled dose-ranging Phase 2b study
Oakes, Tina Marie Myers, Skljarevski, Vladimir, Zhang, Qi, Kielbasa, William, Hodsdon, Michael E, Detke, Holland C, Camporeale, Angelo, Saper, Joel R
Published in Cephalalgia (01.05.2018)
Published in Cephalalgia (01.05.2018)
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Safety, Tolerability, and Pharmacokinetics of Mevidalen (LY3154207), a Centrally Acting Dopamine D1 Receptor‐Positive Allosteric Modulator (D1PAM), in Healthy Subjects
Wilbraham, Darren, Biglan, Kevin M., Svensson, Kjell A., Tsai, Max, Kielbasa, William
Published in Clinical pharmacology in drug development (01.04.2021)
Published in Clinical pharmacology in drug development (01.04.2021)
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Assessment of immunogenicity from galcanezumab phase 3 trials in patients with episodic or chronic migraine
Martinez, James M, Hindiyeh, Nada, Anglin, Greg, Kalidas, Kavita, Hodsdon, Michael E, Kielbasa, William, Moser, Brian A, Pearlman, Eric M, Garces, Sandra
Published in Cephalalgia (01.08.2020)
Published in Cephalalgia (01.08.2020)
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Single and multiple ascending dose studies in healthy volunteers to assess the safety and PK of LY3372689, an inhibitor of the O‐GlcNAcase (OGA) enzyme
Lowe, Stephen L, Goldsmith, Paul, Phipps, Krista M, Kevin, Donnelly B, Biglan, Kevin, Mancini, Michele, Nuthall, Hugh Norman, Mergott, Dustin J., Kielbasa, William
Published in Alzheimer's & dementia (01.12.2021)
Published in Alzheimer's & dementia (01.12.2021)
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A MULTIPLE ASCENDING-DOSE STUDY OF THE PHARMACOKINETICS AND SAFETY OF LY3154207, A CENTRALLY-ACTING DOPAMINE D1 RECEPTOR POSITIVE ALLOSTERIC MODULATOR (D1 PAM), IN HEALTHY SUBJECTS
Biglan, Kevin, Svensson, Kjell A., Wilbraham, Darren, Tsai, Max, Kielbasa, William
Published in Alzheimer's & dementia (01.07.2019)
Published in Alzheimer's & dementia (01.07.2019)
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P1‐057: A MULTIPLE ASCENDING‐DOSE STUDY OF THE PHARMACOKINETICS AND SAFETY OF LY3154207, A CENTRALLY‐ACTING DOPAMINE D1 RECEPTOR POSITIVE ALLOSTERIC MODULATOR (D1 PAM), IN HEALTHY SUBJECTS
Biglan, Kevin, Svensson, Kjell A., Wilbraham, Darren, Tsai, Max, Kielbasa, William
Published in Alzheimer's & dementia (01.07.2019)
Published in Alzheimer's & dementia (01.07.2019)
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Safety, Tolerability, and Pharmacokinetics of Mevidalen (LY3154207), a Centrally Acting Dopamine D1 Receptor–Positive Allosteric Modulator, in Patients With Parkinson Disease
Wilbraham, Darren, Biglan, Kevin M., Svensson, Kjell A., Tsai, Max, Pugh, Melissa, Ardayfio, Paul, Kielbasa, William
Published in Clinical pharmacology in drug development (01.03.2022)
Published in Clinical pharmacology in drug development (01.03.2022)
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