Macrocyclic MEK1/2 inhibitor with efficacy in a mouse model of cardiomyopathy caused by lamin A/C gene mutation
Wu, Wei, Chordia, Mahendra D., Hart, Barry P., Kumarasinghe, E. Sathyajith, Ji, Min K., Bhargava, Ajay, Lawlor, Michael W., Shin, Ji-Yeon, Sera, Fusako, Homma, Shunichi, Muchir, Antoine, Khire, Uday R., Worman, Howard J.
Published in Bioorganic & medicinal chemistry (01.02.2017)
Published in Bioorganic & medicinal chemistry (01.02.2017)
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Journal Article
Quinazolinone Derivatives as Orally Available Ghrelin Receptor Antagonists for the Treatment of Diabetes and Obesity
Rudolph, Joachim, Esler, William P, O'Connor, Stephen, Coish, Philip D. G, Wickens, Philip L, Brands, Michael, Bierer, Donald E, Bloomquist, Brian T, Bondar, Georgiy, Chen, Libing, Chuang, Chih-Yuan, Claus, Thomas H, Fathi, Zahra, Fu, Wenlang, Khire, Uday R, Kristie, James A, Liu, Xiao-Gao, Lowe, Derek B, McClure, Andrea C, Michels, Martin, Ortiz, Astrid A, Ramsden, Philip D, Schoenleber, Robert W, Shelekhin, Tatiana E, Vakalopoulos, Alexandros, Tang, Weifeng, Wang, Lei, Yi, Lin, Gardell, Stephen J, Livingston, James N, Sweet, Laurel J, Bullock, William H
Published in Journal of medicinal chemistry (18.10.2007)
Published in Journal of medicinal chemistry (18.10.2007)
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Journal Article
Total Synthesis of the Polyene Macrolide Roflamycoin
Rychnovsky, Scott D, Khire, Uday R, Yang, Guang
Published in Journal of the American Chemical Society (26.02.1997)
Published in Journal of the American Chemical Society (26.02.1997)
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Journal Article
Omega-carboxypyridyl substituted ureas as Raf kinase inhibitors: SAR of the amide substituent
Khire, Uday R., Bankston, Donald, Barbosa, James, Brittelli, David R., Caringal, Yolanda, Carlson, Robert, Dumas, Jacques, Gane, Todd, Heald, Sarah L., Hibner, Barbara, Johnson, Jeffrey S., Katz, Michael E., Kennure, Nancy, Kingery-Wood, Jill, Lee, Wendy, Liu, Xiao-Gao, Lowinger, Timothy B., McAlexander, Ian, Monahan, Mary-Katherine, Natero, Reina, Renick, Joel, Riedl, Bernd, Rong, Hong, Sibley, Robert N., Smith, Roger A., Wolanin, Donald
Published in Bioorganic & medicinal chemistry letters (09.02.2004)
Published in Bioorganic & medicinal chemistry letters (09.02.2004)
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Journal Article
SAR of a novel ‘Anthranilamide Like’ series of VEGFR-2, multi protein kinase inhibitors for the treatment of cancer
Wickens, Philip, Kluender, Harold, Dixon, Julie, Brennan, Catherine, Achebe, Furahi, Bacchiocchi, Antonella, Bankston, Don, Bierer, Donald, Brands, Michael, Braun, Debbie, Brown, Melissa S., Chuang, Chih-Yuan, Dumas, Jacques, Enyedy, Istvan, Hofilena, Gloria, Hong, Zhenqiu, Housley, Tim, Jones, Benjamin, Khire, Uday, Kreiman, Charles, Kumarasinghe, Ellalahewage, Lowinger, Timothy, Ott-Morgan, Ronda, Perkins, Louise, Phillips, Barton, Schoenleber, Robert, Scott, William J., Sheeler, Ryan, Redman, Anikó, Sun, Xiuying, Taylor, Ian, Wang, Lei, Wilhelm, Scott, Zhang, Xiaomei, Zhang, Mingbao, Sullivan, Elizabeth, Carter, Christopher, Miglarese, Mark, Levy, Joan
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
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Journal Article
Prins Desymmetrization of a C 2-Symmetric Diol: Application to the Synthesis of 17-Deoxyroflamycoin
Rychnovsky, Scott D, Yang, Guang, Hu, Yueqing, Khire, Uday R
Published in Journal of organic chemistry (16.05.1997)
Published in Journal of organic chemistry (16.05.1997)
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Journal Article
B-(.gamma.-(Trimethylsilyl)propargyl)diisopinocampheylborane: A New, Highly Efficient Reagent for the Enantioselective Propargylboration of Aldehydes. Synthesis of Trimethylsilyl-Substituted and Parent .alpha.-Allenic Alcohols in High Optical Purity
Brown, Herbert C, Khire, Uday R, Narla, Gowriswari
Published in Journal of organic chemistry (01.12.1995)
Published in Journal of organic chemistry (01.12.1995)
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Journal Article
Organoboranes for Synthesis. 15. B-Allenyl-9-BBN: A Highly Regiospecific and Chemoselective Reagent for Allenylboration of Representative Carbonyl Compounds, Leading to Homopropargylic Alcohols and Amines
Brown, Herbert C, Khire, Uday R, Narla, Gowriswari, Racherla, Uday S
Published in Journal of organic chemistry (01.02.1995)
Published in Journal of organic chemistry (01.02.1995)
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Journal Article
Abstract 736: Novel, potent MEK inhibitor CIP-1374 for the treatment of cancer
Chordia, Mahendra, Khire, Uday, Bhargava, Ajay
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Journal Article
Inhibition of Macrophage Migration Inhibitory Factor by a Chimera of Two Allosteric Binders
Cirillo, Pier F, Asojo, Oluwatoyin A, Khire, Uday, Lee, Yashang, Mootien, Sara, Hegan, Peter, Sutherland, Alan G, Peterson-Roth, Elizabeth, Ledizet, Michel, Koski, Raymond A, Anthony, Karen G
Published in ACS medicinal chemistry letters (08.10.2020)
Published in ACS medicinal chemistry letters (08.10.2020)
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Journal Article
First International Conference on RASopathies and Neurofibromatoses in Asia: Identification and advances of new therapeutics
Rauen, Katherine A., Alsaegh, Abeer, Ben‐Shachar, Shay, Berman, Yemima, Blakeley, Jaishri, Cordeiro, Isabel, Elgersma, Ype, Evans, D. Gareth, Fisher, Michael J., Frayling, Ian M., George, Joshi, Huson, Susan M., Kerr, Bronwyn, Khire, Uday, Korf, Bruce, Legius, Eric, Messiaen, Ludwine, van Minkelen, Rick, Nampoothiri, Sheela, Ngeow, Joanne, Parada, Luis F., Phadke, Shubha, Pillai, Ashok, Plotkin, Scott R., Puri, Ratna, Raji, Anup, Ramesh, Vijaya, Ratner, Nancy, Shankar, Suma P., Sharda, Sheetal, Tambe, Anant, Vikkula, Miikka, Widemann, Brigitte C., Wolkenstein, Pierre, Upadhyaya, Meena
Published in American journal of medical genetics. Part A (01.06.2019)
Published in American journal of medical genetics. Part A (01.06.2019)
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Journal Article
Conference Proceeding
Abstract 5470: Potent MEK inhibitor CIP-137401: Preclinical studies
Khire, Uday R., Bhargava, Ajay, Hart, Barry, Chordia, Mahendra D.
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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Journal Article
Prins Desymmetrization of a C(2)-Symmetric Diol: Application to the Synthesis of 17-Deoxyroflamycoin
Rychnovsky, Scott D., Yang, Guang, Hu, Yueqing, Khire, Uday R.
Published in Journal of organic chemistry (16.05.1997)
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Published in Journal of organic chemistry (16.05.1997)
Journal Article
SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS
WANG LEI, DIXON JULIE, LIU ZHENG, KHIRE UDAY, KLUENDER HAROLD, PARCELLA KYLE, MICHELS MARTIN, ZHANG ZHONGHUA, NEWCOM JASON, MAGNUSON STEVEN, O'CONNOR STEPHEN J, PHILLIPS BARTON, ACHEBE FURAHI, HONG ZHENQIU, CHANDLER BRENT
Year of Publication 26.12.2013
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Year of Publication 26.12.2013
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