A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models
Dai, Xuezhi, James, Richard G, Habib, Tania, Singh, Swati, Jackson, Shaun, Khim, Socheath, Moon, Randall T, Liggitt, Denny, Wolf-Yadlin, Alejandro, Buckner, Jane H, Rawlings, David J
Published in The Journal of clinical investigation (01.05.2013)
Published in The Journal of clinical investigation (01.05.2013)
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The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity
Gorman, Jacquelyn A, Hundhausen, Christian, Errett, John S, Stone, Amy E, Allenspach, Eric J, Ge, Yan, Arkatkar, Tanvi, Clough, Courtnee, Dai, Xuezhi, Khim, Socheath, Pestal, Kathleen, Liggitt, Denny, Cerosaletti, Karen, Stetson, Daniel B, James, Richard G, Oukka, Mohamed, Concannon, Patrick, Gale, Jr, Michael, Buckner, Jane H, Rawlings, David J
Published in Nature immunology (01.07.2017)
Published in Nature immunology (01.07.2017)
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Opposing impact of B cell-intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation
Jackson, Shaun W, Scharping, Nicole E, Kolhatkar, Nikita S, Khim, Socheath, Schwartz, Marc A, Li, Quan-Zhen, Hudkins, Kelly L, Alpers, Charles E, Liggitt, Denny, Rawlings, David J
Published in The Journal of immunology (1950) (15.05.2014)
Published in The Journal of immunology (1950) (15.05.2014)
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Activated interleukin-7 receptor signaling drives B-cell acute lymphoblastic leukemia in mice
Thomas, Kerri R, Allenspach, Eric J, Camp, Nathan D, Wray-Dutra, Michelle N, Khim, Socheath, Zielinska-Kwiatkowska, Anna, Timms, Andrew E, Loftus, Joseph P, Liggitt, H Denny, Georgopoulos, Katia, Tasian, Sarah K, James, Richard G, Rawlings, David J
Published in Leukemia (01.01.2022)
Published in Leukemia (01.01.2022)
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The Autoimmune Risk Variant PTPN22 C1858T Alters B Cell Tolerance at Discrete Checkpoints and Differentially Shapes the Naive Repertoire
Metzler, Genita, Dai, Xuezhi, Thouvenel, Christopher D, Khim, Socheath, Habib, Tania, Buckner, Jane H, Rawlings, David J
Published in The Journal of immunology (1950) (01.10.2017)
Published in The Journal of immunology (1950) (01.10.2017)
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WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity
Becker-Herman, Shirly, Meyer-Bahlburg, Almut, Schwartz, Marc A, Jackson, Shaun W, Hudkins, Kelly L, Liu, Chaohong, Sather, Blythe D, Khim, Socheath, Liggitt, Denny, Song, Wenxia, Silverman, Gregg J, Alpers, Charles E, Rawlings, David J
Published in The Journal of experimental medicine (26.09.2011)
Published in The Journal of experimental medicine (26.09.2011)
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Activated CARD11 accelerates germinal center kinetics, promoting mTORC1 and terminal differentiation
Wray-Dutra, Michelle N, Chawla, Raghav, Thomas, Kerri R, Seymour, Brenda J, Arkatkar, Tanvi, Sommer, Karen M, Khim, Socheath, Trapnell, Cole, James, Richard G, Rawlings, David J
Published in The Journal of experimental medicine (03.09.2018)
Published in The Journal of experimental medicine (03.09.2018)
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The TYK2 -P1104A Autoimmune Protective Variant Limits Coordinate Signals Required to Generate Specialized T Cell Subsets
Gorman, Jacquelyn A, Hundhausen, Christian, Kinsman, Mackenzie, Arkatkar, Tanvi, Allenspach, Eric J, Clough, Courtnee, West, Samuel E, Thomas, Kerri, Eken, Ahmet, Khim, Socheath, Hale, Malika, Oukka, Mohamed, Jackson, Shaun W, Cerosaletti, Karen, Buckner, Jane H, Rawlings, David J
Published in Frontiers in immunology (2019)
Published in Frontiers in immunology (2019)
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The Tec Kinase-Regulated Phosphoproteome Reveals a Mechanism for the Regulation of Inhibitory Signals in Murine Macrophages
Tampella, Giacomo, Kerns, Hannah M, Niu, Deqiang, Singh, Swati, Khim, Socheath, Bosch, Katherine A, Garrett, Meghan E, Moguche, Albanus, Evans, Erica, Browning, Beth, Jahan, Tahmina A, Nacht, Mariana, Wolf-Yadlin, Alejandro, Plebani, Alessandro, Hamerman, Jessica A, Rawlings, David J, James, Richard G
Published in The Journal of immunology (1950) (01.07.2015)
Published in The Journal of immunology (1950) (01.07.2015)
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Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis
Meyer-Bahlburg, Almut, Becker-Herman, Shirly, Humblet-Baron, Stephanie, Khim, Socheath, Weber, Michele, Bouma, Gerben, Thrasher, Adrian J., Batista, Facundo D., Rawlings, David J.
Published in Blood (15.11.2008)
Published in Blood (15.11.2008)
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Effective, safe, and sustained correction of murine XLA using a UCOE-BTK promoter-based lentiviral vector
Seymour, Brenda J., Singh, Swati, Certo, Hannah M., Sommer, Karen, Sather, Blythe D., Khim, Socheath, Clough, Courtnee, Hale, Malika, Pangallo, Joseph, Ryu, Byoung Y., Khan, Iram F., Adair, Jennifer E., Rawlings, David J.
Published in Molecular therapy. Methods & clinical development (12.03.2021)
Published in Molecular therapy. Methods & clinical development (12.03.2021)
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Safe and Effective Gene Therapy for Murine Wiskott-Aldrich Syndrome Using an Insulated Lentiviral Vector
Singh, Swati, Khan, Iram, Khim, Socheath, Seymour, Brenda, Sommer, Karen, Wielgosz, Matthew, Norgaard, Zachary, Kiem, Hans-Peter, Adair, Jennifer, Liggitt, Denny, Nienhuis, Arthur, Rawlings, David J
Published in Molecular therapy. Methods & clinical development (17.03.2017)
Published in Molecular therapy. Methods & clinical development (17.03.2017)
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Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells
Bermejo, Daniela A, Jackson, Shaun W, Gorosito-Serran, Melisa, Acosta-Rodriguez, Eva V, Amezcua-Vesely, Maria C, Sather, Blythe D, Singh, Akhilesh K, Khim, Socheath, Mucci, Juan, Liggitt, Denny, Campetella, Oscar, Oukka, Mohamed, Gruppi, Adriana, Rawlings, David J
Published in Nature immunology (01.05.2013)
Published in Nature immunology (01.05.2013)
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B cell intrinsic TLR signals amplify but are not required for humoral immunity
Meyer-Bahlburg, Almut, Khim, Socheath, Rawlings, David J
Published in The Journal of experimental medicine (24.12.2007)
Published in The Journal of experimental medicine (24.12.2007)
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Altered BCR and TLR signals promote enhanced positive selection of autoreactive transitional B cells in Wiskott-Aldrich syndrome
Kolhatkar, Nikita S, Brahmandam, Archana, Thouvenel, Christopher D, Becker-Herman, Shirly, Jacobs, Holly M, Schwartz, Marc A, Allenspach, Eric J, Khim, Socheath, Panigrahi, Anil K, Luning Prak, Eline T, Thrasher, Adrian J, Notarangelo, Luigi D, Candotti, Fabio, Torgerson, Troy R, Sanz, Ignacio, Rawlings, David J
Published in The Journal of experimental medicine (21.09.2015)
Published in The Journal of experimental medicine (21.09.2015)
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Ubiquitous high-level gene expression in hematopoietic lineages provides effective lentiviral gene therapy of murine Wiskott-Aldrich syndrome
Astrakhan, Alexander, Sather, Blythe D., Ryu, Byoung Y., Khim, Socheath, Singh, Swati, Humblet-Baron, Stephanie, Ochs, Hans D., Miao, Carol H., Rawlings, David J.
Published in Blood (10.05.2012)
Published in Blood (10.05.2012)
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B‐cell intrinsic TLR7 signals promote depletion of the marginal zone in a murine model of Wiskott–Aldrich syndrome
Kolhatkar, Nikita S., Scharping, Nicole E., Sullivan, Jenna M., Jacobs, Holly M., Schwartz, Marc A., Khim, Socheath, Notarangelo, Luigi D., Thrasher, Adrian J., Rawlings, David J., Jackson, Shaun W.
Published in European journal of immunology (01.10.2015)
Published in European journal of immunology (01.10.2015)
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238. BTK-Promoter LV Vectors Utilizing Conserved Intron Element Mediate Functional Rescue in Murine XLA
Singh, Swati, Seymour, Brenda, Sommer, Karen, Khan, Iram, Khim, Socheath, Hale, Malika, Clough, Courtnee, Rawlings, David J.
Published in Molecular therapy (01.05.2015)
Published in Molecular therapy (01.05.2015)
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Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis
Humblet-Baron, Stephanie, Sather, Blythe, Anover, Stephanie, Becker-Herman, Shirly, Kasprowicz, Debora J, Khim, Socheath, Nguyen, Thuc, Hudkins-Loya, Kelly, Alpers, Charles E, Ziegler, Steve F, Ochs, Hans, Torgerson, Troy, Campbell, Daniel J, Rawlings, David J
Published in The Journal of clinical investigation (01.02.2007)
Published in The Journal of clinical investigation (01.02.2007)
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