Association between adiposity and cardiovascular outcomes: an umbrella review and meta-analysis of observational and Mendelian randomization studies
Kim, Min Seo, Kim, Won Jun, Khera, Amit V, Kim, Jong Yeob, Yon, Dong Keon, Lee, Seung Won, Shin, Jae Il, Won, Hong-Hee
Published in European heart journal (07.09.2021)
Published in European heart journal (07.09.2021)
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Journal Article
Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood
Khera, Amit V., Chaffin, Mark, Wade, Kaitlin H., Zahid, Sohail, Brancale, Joseph, Xia, Rui, Distefano, Marina, Senol-Cosar, Ozlem, Haas, Mary E., Bick, Alexander, Aragam, Krishna G., Lander, Eric S., Smith, George Davey, Mason-Suares, Heather, Fornage, Myriam, Lebo, Matthew, Timpson, Nicholas J., Kaplan, Lee M., Kathiresan, Sekar
Published in Cell (18.04.2019)
Published in Cell (18.04.2019)
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Journal Article
Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease
Khera, Amit V, Emdin, Connor A, Drake, Isabel, Natarajan, Pradeep, Bick, Alexander G, Cook, Nancy R, Chasman, Daniel I, Baber, Usman, Mehran, Roxana, Rader, Daniel J, Fuster, Valentin, Boerwinkle, Eric, Melander, Olle, Orho-Melander, Marju, Ridker, Paul M, Kathiresan, Sekar
Published in The New England journal of medicine (15.12.2016)
Published in The New England journal of medicine (15.12.2016)
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Journal Article
Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions
Fahed, Akl C, Wang, Minxian, Homburger, Julian R, Patel, Aniruddh P, Bick, Alexander G, Neben, Cynthia L, Lai, Carmen, Brockman, Deanna, Philippakis, Anthony, Ellinor, Patrick T, Cassa, Christopher A, Lebo, Matthew, Ng, Kenney, Lander, Eric S, Zhou, Alicia Y, Kathiresan, Sekar, Khera, Amit V
Published in Nature communications (20.08.2020)
Published in Nature communications (20.08.2020)
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Journal Article
Improving reporting standards for polygenic scores in risk prediction studies
Wand, Hannah, Lambert, Samuel A, Tamburro, Cecelia, Iacocca, Michael A, O'Sullivan, Jack W, Sillari, Catherine, Kullo, Iftikhar J, Rowley, Robb, Dron, Jacqueline S, Brockman, Deanna, Venner, Eric, McCarthy, Mark I, Antoniou, Antonis C, Easton, Douglas F, Hegele, Robert A, Khera, Amit V, Chatterjee, Nilanjan, Kooperberg, Charles, Edwards, Karen, Vlessis, Katherine, Kinnear, Kim, Danesh, John N, Parkinson, Helen, Ramos, Erin M, Roberts, Megan C, Ormond, Kelly E, Khoury, Muin J, Janssens, A Cecile J W, Goddard, Katrina A B, Kraft, Peter, MacArthur, Jaqueline A L, Inouye, Michael, Wojcik, Genevieve L
Published in Nature (London) (11.03.2021)
Published in Nature (London) (11.03.2021)
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Journal Article
Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy
Pirruccello, James P, Bick, Alexander, Wang, Minxian, Chaffin, Mark, Friedman, Samuel, Yao, Jie, Guo, Xiuqing, Venkatesh, Bharath Ambale, Taylor, Kent D, Post, Wendy S, Rich, Stephen, Lima, Joao A C, Rotter, Jerome I, Philippakis, Anthony, Lubitz, Steven A, Ellinor, Patrick T, Khera, Amit V, Kathiresan, Sekar, Aragam, Krishna G
Published in Nature communications (07.05.2020)
Published in Nature communications (07.05.2020)
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Journal Article
Cholesterol Efflux Capacity, High-Density Lipoprotein Function, and Atherosclerosis
Khera, Amit V, Cuchel, Marina, de la Llera-Moya, Margarita, Rodrigues, Amrith, Burke, Megan F, Jafri, Kashif, French, Benjamin C, Phillips, Julie A, Mucksavage, Megan L, Wilensky, Robert L, Mohler, Emile R, Rothblat, George H, Rader, Daniel J
Published in The New England journal of medicine (13.01.2011)
Published in The New England journal of medicine (13.01.2011)
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Journal Article
ANGPTL3 Deficiency and Protection Against Coronary Artery Disease
Stitziel, Nathan O., MD, PhD, Khera, Amit V., MD, Wang, Xiao, PhD, Bierhals, Andrew J., MD, MPH, Vourakis, A. Christina, BA, Sperry, Alexandra E., BA, Natarajan, Pradeep, MD, Klarin, Derek, MD, Emdin, Connor A., DPhil, Zekavat, Seyedeh M., BSc, Nomura, Akihiro, MD, Erdmann, Jeanette, PhD, Schunkert, Heribert, MD, Samani, Nilesh J., MD, Kraus, William E., MD, Shah, Svati H., MD, MPH, Yu, Bing, PhD, Boerwinkle, Eric, PhD, Rader, Daniel J., MD, Gupta, Namrata, PhD, Frossard, Philippe M., PhD, Rasheed, Asif, MBBS, Danesh, John, DPhil, Lander, Eric S., PhD, Gabriel, Stacey, PhD, Saleheen, Danish, MBBS, PhD, Musunuru, Kiran, MD, PhD, MPH, Kathiresan, Sekar, MD
Published in Journal of the American College of Cardiology (25.04.2017)
Published in Journal of the American College of Cardiology (25.04.2017)
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Journal Article
Leveraging fine-mapping and multipopulation training data to improve cross-population polygenic risk scores
Weissbrod, Omer, Kanai, Masahiro, Shi, Huwenbo, Gazal, Steven, Peyrot, Wouter J, Khera, Amit V, Okada, Yukinori, Martin, Alicia R, Finucane, Hilary K, Price, Alkes L
Published in Nature genetics (01.04.2022)
Published in Nature genetics (01.04.2022)
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Journal Article
Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease
Klarin, Derek, Zhu, Qiuyu Martin, Emdin, Connor A, Chaffin, Mark, Horner, Steven, McMillan, Brian J, Leed, Alison, Weale, Michael E, Spencer, Chris C A, Aguet, François, Segrè, Ayellet V, Ardlie, Kristin G, Khera, Amit V, Kaushik, Virendar K, Natarajan, Pradeep, Kathiresan, Sekar
Published in Nature genetics (01.09.2017)
Published in Nature genetics (01.09.2017)
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Journal Article
A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease
Emdin, Connor A, Haas, Mary E, Khera, Amit V, Aragam, Krishna, Chaffin, Mark, Klarin, Derek, Hindy, George, Jiang, Lan, Wei, Wei-Qi, Feng, Qiping, Karjalainen, Juha, Havulinna, Aki, Kiiskinen, Tuomo, Bick, Alexander, Ardissino, Diego, Wilson, James G, Schunkert, Heribert, McPherson, Ruth, Watkins, Hugh, Elosua, Roberto, Bown, Matthew J, Samani, Nilesh J, Baber, Usman, Erdmann, Jeanette, Gupta, Namrata, Danesh, John, Saleheen, Danish, Chang, Kyong-Mi, Vujkovic, Marijana, Voight, Ben, Damrauer, Scott, Lynch, Julie, Kaplan, David, Serper, Marina, Tsao, Philip, Mercader, Josep, Hanis, Craig, Daly, Mark, Denny, Joshua, Gabriel, Stacey, Kathiresan, Sekar
Published in PLoS genetics (01.04.2020)
Published in PLoS genetics (01.04.2020)
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Journal Article
Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots
Agrawal, Saaket, Wang, Minxian, Klarqvist, Marcus D R, Smith, Kirk, Shin, Joseph, Dashti, Hesam, Diamant, Nathaniel, Choi, Seung Hoan, Jurgens, Sean J, Ellinor, Patrick T, Philippakis, Anthony, Claussnitzer, Melina, Ng, Kenney, Udler, Miriam S, Batra, Puneet, Khera, Amit V
Published in Nature communications (30.06.2022)
Published in Nature communications (30.06.2022)
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Journal Article
Polygenic Score Assessed in Young Adulthood and Onset of Subclinical Atherosclerosis and Coronary Heart Disease
Emdin, Connor A, Xia, Rui, Agrawal, Saaket, Rana, Jamal S, Lloyd-Jones, Donald, Fornage, Myriam, Khera, Amit V
Published in Journal of the American College of Cardiology (19.07.2022)
Published in Journal of the American College of Cardiology (19.07.2022)
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Journal Article
Race, socioeconomic deprivation, and hospitalization for COVID-19 in English participants of a national biobank
Patel, Aniruddh P, Paranjpe, Manish D, Kathiresan, Nina P, Rivas, Manuel A, Khera, Amit V
Published in International journal for equity in health (06.07.2020)
Published in International journal for equity in health (06.07.2020)
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Journal Article
GalNAc-Lipid nanoparticles enable non-LDLR dependent hepatic delivery of a CRISPR base editing therapy
Kasiewicz, Lisa N, Biswas, Souvik, Beach, Aaron, Ren, Huilan, Dutta, Chaitali, Mazzola, Anne Marie, Rohde, Ellen, Chadwick, Alexandra, Cheng, Christopher, Garcia, Sara P, Iyer, Sowmya, Matsumoto, Yuri, Khera, Amit V, Musunuru, Kiran, Kathiresan, Sekar, Malyala, Padma, Rajeev, Kallanthottathil G, Bellinger, Andrew M
Published in Nature communications (15.05.2023)
Published in Nature communications (15.05.2023)
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Journal Article
BMI-adjusted adipose tissue volumes exhibit depot-specific and divergent associations with cardiometabolic diseases
Agrawal, Saaket, Klarqvist, Marcus D R, Diamant, Nathaniel, Stanley, Takara L, Ellinor, Patrick T, Mehta, Nehal N, Philippakis, Anthony, Ng, Kenney, Claussnitzer, Melina, Grinspoon, Steven K, Batra, Puneet, Khera, Amit V
Published in Nature communications (17.01.2023)
Published in Nature communications (17.01.2023)
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Journal Article
Low coverage whole genome sequencing enables accurate assessment of common variants and calculation of genome-wide polygenic scores
Homburger, Julian R, Neben, Cynthia L, Mishne, Gilad, Zhou, Alicia Y, Kathiresan, Sekar, Khera, Amit V
Published in Genome medicine (26.11.2019)
Published in Genome medicine (26.11.2019)
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Journal Article
Polygenic Risk Score Predicts Sudden Death in Patients With Coronary Disease and Preserved Systolic Function
Sandhu, Roopinder K., Dron, Jacqueline S., Liu, Yunxian, Moorthy, M. Vinayaga, Chatterjee, Neal A., Ellinor, Patrick T., Chasman, Daniel I., Cook, Nancy R., Khera, Amit V., Albert, Christine M.
Published in Journal of the American College of Cardiology (30.08.2022)
Published in Journal of the American College of Cardiology (30.08.2022)
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Journal Article