Mendelian Randomization
Emdin, Connor A, Khera, Amit V, Kathiresan, Sekar
Published in JAMA : the journal of the American Medical Association (21.11.2017)
Published in JAMA : the journal of the American Medical Association (21.11.2017)
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Journal Article
Association between adiposity and cardiovascular outcomes: an umbrella review and meta-analysis of observational and Mendelian randomization studies
Kim, Min Seo, Kim, Won Jun, Khera, Amit V, Kim, Jong Yeob, Yon, Dong Keon, Lee, Seung Won, Shin, Jae Il, Won, Hong-Hee
Published in European heart journal (07.09.2021)
Published in European heart journal (07.09.2021)
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Journal Article
Efficacy and Safety of an Investigational Single-Course CRISPR Base-Editing Therapy Targeting PCSK9 in Nonhuman Primate and Mouse Models
Lee, Richard G, Mazzola, Anne Marie, Braun, Maurine C, Platt, Colin, Vafai, Scott B, Kathiresan, Sekar, Rohde, Ellen, Bellinger, Andrew M, Khera, Amit V
Published in Circulation (New York, N.Y.) (17.01.2023)
Published in Circulation (New York, N.Y.) (17.01.2023)
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Journal Article
Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood
Khera, Amit V., Chaffin, Mark, Wade, Kaitlin H., Zahid, Sohail, Brancale, Joseph, Xia, Rui, Distefano, Marina, Senol-Cosar, Ozlem, Haas, Mary E., Bick, Alexander, Aragam, Krishna G., Lander, Eric S., Smith, George Davey, Mason-Suares, Heather, Fornage, Myriam, Lebo, Matthew, Timpson, Nicholas J., Kaplan, Lee M., Kathiresan, Sekar
Published in Cell (18.04.2019)
Published in Cell (18.04.2019)
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Journal Article
Quantifying and Understanding the Higher Risk of Atherosclerotic Cardiovascular Disease Among South Asian Individuals: Results From the UK Biobank Prospective Cohort Study
Patel, Aniruddh P, Wang, Minxian, Kartoun, Uri, Ng, Kenney, Khera, Amit V
Published in Circulation (New York, N.Y.) (10.08.2021)
Published in Circulation (New York, N.Y.) (10.08.2021)
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Journal Article
Leveraging fine-mapping and multipopulation training data to improve cross-population polygenic risk scores
Weissbrod, Omer, Kanai, Masahiro, Shi, Huwenbo, Gazal, Steven, Peyrot, Wouter J, Khera, Amit V, Okada, Yukinori, Martin, Alicia R, Finucane, Hilary K, Price, Alkes L
Published in Nature genetics (01.04.2022)
Published in Nature genetics (01.04.2022)
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Journal Article
Lp(a) (Lipoprotein[a]) Concentrations and Incident Atherosclerotic Cardiovascular Disease: New Insights From a Large National Biobank
Patel, Aniruddh P, Wang, Minxian, Pirruccello, James P, Ellinor, Patrick T, Ng, Kenney, Kathiresan, Sekar, Khera, Amit V
Published in Arteriosclerosis, thrombosis, and vascular biology (01.01.2021)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.01.2021)
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Journal Article
Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations
Khera, Amit V, Chaffin, Mark, Aragam, Krishna G, Haas, Mary E, Roselli, Carolina, Choi, Seung Hoan, Natarajan, Pradeep, Lander, Eric S, Lubitz, Steven A, Ellinor, Patrick T, Kathiresan, Sekar
Published in Nature genetics (01.09.2018)
Published in Nature genetics (01.09.2018)
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Journal Article
Association of Genetic Variation With Cirrhosis: A Multi-Trait Genome-Wide Association and Gene–Environment Interaction Study
Emdin, Connor A., Haas, Mary, Ajmera, Veeral, Simon, Tracey G., Homburger, Julian, Neben, Cynthia, Jiang, Lan, Wei, Wei-Qi, Feng, Qiping, Zhou, Alicia, Denny, Joshua, Corey, Kathleen, Loomba, Rohit, Kathiresan, Sekar, Khera, Amit V.
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2021)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2021)
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Journal Article
Whole-Genome Sequencing to Characterize Monogenic and Polygenic Contributions in Patients Hospitalized With Early-Onset Myocardial Infarction
Khera, Amit V., Chaffin, Mark, Zekavat, Seyedeh M., Collins, Ryan L., Roselli, Carolina, Natarajan, Pradeep, Lichtman, Judith H., D’Onofrio, Gail, Mattera, Jennifer, Dreyer, Rachel, Spertus, John A., Taylor, Kent D., Psaty, Bruce M., Rich, Stephen S., Post, Wendy, Gupta, Namrata, Gabriel, Stacey, Lander, Eric, Ida Chen, Yii-Der, Talkowski, Michael E., Rotter, Jerome I., Krumholz, Harlan M., Kathiresan, Sekar
Published in Circulation (New York, N.Y.) (26.03.2019)
Published in Circulation (New York, N.Y.) (26.03.2019)
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Journal Article
A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease
Emdin, Connor A, Haas, Mary E, Khera, Amit V, Aragam, Krishna, Chaffin, Mark, Klarin, Derek, Hindy, George, Jiang, Lan, Wei, Wei-Qi, Feng, Qiping, Karjalainen, Juha, Havulinna, Aki, Kiiskinen, Tuomo, Bick, Alexander, Ardissino, Diego, Wilson, James G, Schunkert, Heribert, McPherson, Ruth, Watkins, Hugh, Elosua, Roberto, Bown, Matthew J, Samani, Nilesh J, Baber, Usman, Erdmann, Jeanette, Gupta, Namrata, Danesh, John, Saleheen, Danish, Chang, Kyong-Mi, Vujkovic, Marijana, Voight, Ben, Damrauer, Scott, Lynch, Julie, Kaplan, David, Serper, Marina, Tsao, Philip, Mercader, Josep, Hanis, Craig, Daly, Mark, Denny, Joshua, Gabriel, Stacey, Kathiresan, Sekar
Published in PLoS genetics (01.04.2020)
Published in PLoS genetics (01.04.2020)
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Journal Article
Association of Habitual Alcohol Intake With Risk of Cardiovascular Disease
Biddinger, Kiran J, Emdin, Connor A, Haas, Mary E, Wang, Minxian, Hindy, George, Ellinor, Patrick T, Kathiresan, Sekar, Khera, Amit V, Aragam, Krishna G
Published in JAMA network open (01.03.2022)
Published in JAMA network open (01.03.2022)
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Journal Article
Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease
Khera, Amit V, Emdin, Connor A, Drake, Isabel, Natarajan, Pradeep, Bick, Alexander G, Cook, Nancy R, Chasman, Daniel I, Baber, Usman, Mehran, Roxana, Rader, Daniel J, Fuster, Valentin, Boerwinkle, Eric, Melander, Olle, Orho-Melander, Marju, Ridker, Paul M, Kathiresan, Sekar
Published in The New England journal of medicine (15.12.2016)
Published in The New England journal of medicine (15.12.2016)
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Journal Article
Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease
Emdin, Connor A, Khera, Amit V, Natarajan, Pradeep, Klarin, Derek, Zekavat, Seyedeh M, Hsiao, Allan J, Kathiresan, Sekar
Published in JAMA : the journal of the American Medical Association (14.02.2017)
Published in JAMA : the journal of the American Medical Association (14.02.2017)
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Journal Article
Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions
Fahed, Akl C, Wang, Minxian, Homburger, Julian R, Patel, Aniruddh P, Bick, Alexander G, Neben, Cynthia L, Lai, Carmen, Brockman, Deanna, Philippakis, Anthony, Ellinor, Patrick T, Cassa, Christopher A, Lebo, Matthew, Ng, Kenney, Lander, Eric S, Zhou, Alicia Y, Kathiresan, Sekar, Khera, Amit V
Published in Nature communications (20.08.2020)
Published in Nature communications (20.08.2020)
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