Design, Synthesis, In Vitro Anti-cancer Activity, ADMET Profile and Molecular Docking of Novel Triazolo[3,4-a]phthalazine Derivatives Targeting VEGFR-2 Enzyme
El-Helby, Abdel-Ghany A, Sakr, Helmy, Ayyad, Rezk R A, El-Adl, Khaled, Ali, Mamdouh M, Khedr, Fathalla
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Published in Anti-cancer agents in medicinal chemistry (01.01.2018)
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Design, Molecular Docking, Synthesis, Anticancer and Anti-Hyperglycemic Assessments of Thiazolidine-2,4-diones Bearing Sulfonylthiourea Moieties as Potent VEGFR-2 Inhibitors and PPARγ Agonists
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Published in Pharmaceuticals (Basel, Switzerland) (14.02.2022)
Published in Pharmaceuticals (Basel, Switzerland) (14.02.2022)
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Exploration of the VEGFR-2 inhibition activity of phthalazine derivatives: design, synthesis, cytotoxicity, ADMET, molecular docking and dynamic simulation
Bayoumi, Hatem Hussein, Ibrahim, Mohamed-Kamal, Dahab, Mohammed A, Khedr, Fathalla, El-Adl, Khaled
Published in RSC advances (05.07.2024)
Published in RSC advances (05.07.2024)
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Rationale, in silico docking, ADMET profile, design, synthesis and cytotoxicity evaluations of phthalazine derivatives as VEGFR-2 inhibitors and apoptosis inducers
Hatem Hussein Bayoumi, Mohamed-Kamal, Ibrahim, Dahab, Mohammed A, Khedr, Fathalla, El-Adl, Khaled
Published in RSC advances (22.08.2024)
Published in RSC advances (22.08.2024)
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Phthalazine‐based VEGFR‐2 inhibitors: Rationale, design, synthesis, in silico, ADMET profile, docking, and anticancer evaluations
Khedr, Fathalla, Ibrahim, Mohamed‐Kamal, Eissa, Ibrahim H., Abulkhair, Hamada S., El‐Adl, Khaled
Published in Archiv der Pharmazie (Weinheim) (01.11.2021)
Published in Archiv der Pharmazie (Weinheim) (01.11.2021)
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N‐Substituted‐4‐phenylphthalazin‐1‐amine‐derived VEGFR‐2 inhibitors: Design, synthesis, molecular docking, and anticancer evaluation studies
El‐Adl, Khaled, Ibrahim, Mohamed‐Kamal, Khedr, Fathalla, Abulkhair, Hamada S., Eissa, Ibrahim H.
Published in Archiv der Pharmazie (Weinheim) (01.03.2021)
Published in Archiv der Pharmazie (Weinheim) (01.03.2021)
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Five and six membered heterocyclic rings endowed with azobenzene as dual EGFR T790M and VEGFR-2 inhibitors: design, synthesis, in silico ADMET profile, molecular docking, dynamic simulation and anticancer evaluations
Anwer, Kurls E., El-Hddad, Sanadelaslam S. A., Abd El-Sattar, Nour E. A., El-morsy, Ahmed, Khedr, Fathalla, Mohamady, Samy, Keshek, Doaa E., Salama, Samir A., El-Adl, Khaled, Hanafy, Noura S.
Published in RSC advances (30.11.2023)
Published in RSC advances (30.11.2023)
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Iodoquinazoline-derived VEGFR-2 and EGFRT790M dual inhibitors: Design, synthesis, molecular docking and anticancer evaluations
Mohamed, Abeer A., El-Hddad, Sanadelaslam S.A., Aljohani, Ahmed K.B., Khedr, Fathalla, Alatawi, Omar M., Keshek, Doaa E., Ahmed, Sahar, Alsulaimany, Marwa, Almadani, Sara A., El‐Adl, Khaled, Hanafy, Noura S.
Published in Bioorganic chemistry (01.02.2024)
Published in Bioorganic chemistry (01.02.2024)
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Design, Synthesis, Molecular Docking, and Anticancer Activity of Phthalazine Derivatives as VEGFR‐2 Inhibitors
El‐Helby, Abdel‐Ghany A., Ayyad, Rezk R. A., Sakr, Helmy, El‐Adl, Khaled, Ali, Mamdouh M., Khedr, Fathalla
Published in Archiv der Pharmazie (Weinheim) (01.12.2017)
Published in Archiv der Pharmazie (Weinheim) (01.12.2017)
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Journal Article
Iodoquinazoline-derived VEGFR-2 and EGFR T790M dual inhibitors: Design, synthesis, molecular docking and anticancer evaluations
Mohamed, Abeer A, El-Hddad, Sanadelaslam S A, Aljohani, Ahmed K B, Khedr, Fathalla, Alatawi, Omar M, Keshek, Doaa E, Ahmed, Sahar, Alsulaimany, Marwa, Almadani, Sara A, El-Adl, Khaled, Hanafy, Noura S
Published in Bioorganic chemistry (01.02.2024)
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Published in Bioorganic chemistry (01.02.2024)
Journal Article
Five and six membered heterocyclic rings endowed with azobenzene as dual EGFRT790M and VEGFR-2 inhibitors: design, synthesis, in silico ADMET profile, molecular docking, dynamic simulation and anticancer evaluations
Anwer, Kurls E, El-Hddad, Sanadelaslam S A, Nour E A Abd El-Sattar, El-morsy, Ahmed, Khedr, Fathalla, Mohamady, Samy, Keshek, Doaa E, Salama, Samir A, El-Adl, Khaled, Hanafy, Noura S
Published in RSC advances (30.11.2023)
Published in RSC advances (30.11.2023)
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Journal Article
Five and six membered heterocyclic rings endowed with azobenzene as dual EGFR and VEGFR-2 inhibitors: design, synthesis, ADMET profile, molecular docking, dynamic simulation and anticancer evaluations
Anwer, Kurls E, El-Hddad, Sanadelaslam S. A, Abd El-Sattar, Nour E. A, El-morsy, Ahmed, Khedr, Fathalla, Mohamady, Samy, Keshek, Doaa E, Salama, Samir A, El-Adl, Khaled, Hanafy, Noura S
Published in RSC advances (04.12.2023)
Published in RSC advances (04.12.2023)
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