Determination of pharmacokinetic values of calicheamicin-antibody conjugates in mice by plasmon resonance analysis of small (5 μl) blood samples
Boghaert, Erwin R., Khandke, Kiran M., Sridharan, Latha, Dougher, Maureen, DiJoseph, John F., Kunz, Arthur, Hamann, Philip R., Moran, Justin, Chaudhary, Inder, Damle, Nitin K.
Published in Cancer chemotherapy and pharmacology (01.05.2008)
Published in Cancer chemotherapy and pharmacology (01.05.2008)
Get full text
Journal Article
Antibody-targeted chemotherapy of B-cell lymphoma using calicheamicin conjugated to murine or humanized antibody against CD22
DIJOSEPH, John F, POPPLEWELL, Andrew, ZINKEWICH-PEOTTI, Karen, STEPHENS, Sue, WEIR, Neil, DAMLE, Nitin K, TICKLE, Simon, LADYMAN, Heather, LAWSON, Alastair, KUNZ, Arthur, KHANDKE, Kiran, ARMELLINO, Douglas C, BOGHAERT, Erwin R, HAMANN, Philip R
Published in Cancer Immunology, Immunotherapy (01.01.2005)
Published in Cancer Immunology, Immunotherapy (01.01.2005)
Get full text
Journal Article
Antibody-Targeted Chemotherapy with the Calicheamicin Conjugate hu3S193-N-Acetyl γ Calicheamicin Dimethyl Hydrazide Targets Lewisy and Eliminates Lewisy-Positive Human Carcinoma Cells and Xenografts
BOGHAERT, Erwin R, SRIDHARAN, Latha, FROST, Philip, DAMLE, Nitin K, ARMELLINO, Douglas C, KHANDKE, Kiran M, DIJOSEPH, John F, KUNZ, Arthur, DOUGHER, Maureen M, JIANG, Fan, KALYANDRUG, Lyka B, HAMANN, Philip R
Published in Clinical cancer research (01.07.2004)
Published in Clinical cancer research (01.07.2004)
Get full text
Journal Article
Anti-EFNA4 Calicheamicin Conjugates Effectively Target Triple-Negative Breast and Ovarian Tumor-Initiating Cells to Result in Sustained Tumor Regressions
Damelin, Marc, Bankovich, Alexander, Park, Albert, Aguilar, Jorge, Anderson, Wade, Santaguida, Marianne, Aujay, Monette, Fong, Sarah, Khandke, Kiran, Pulito, Virginia, Ernstoff, Elana, Escarpe, Paul, Bernstein, Jeffrey, Pysz, Marybeth, Zhong, Wenyan, Upeslacis, Erik, Lucas, Judy, Lucas, Justin, Nichols, Timothy, Loving, Kathryn, Foord, Orit, Hampl, Johannes, Stull, Robert, Barletta, Frank, Falahatpisheh, Hadi, Sapra, Puja, Gerber, Hans-Peter, Dylla, Scott J
Published in Clinical cancer research (15.09.2015)
Published in Clinical cancer research (15.09.2015)
Get full text
Journal Article
Anti-Extra Domain B Splice Variant of Fibronectin Antibody-Drug Conjugate Eliminates Tumors with Enhanced Efficacy When Combined with Checkpoint Blockade
Hooper, Andrea T, Marquette, Kimberly, Chang, Chao-Pei Betty, Golas, Jonathon, Jain, Sadhana, Lam, My-Hanh, Guffroy, Magali, Leal, Mauricio, Falahatpisheh, Hadi, Mathur, Divya, Chen, Ting, Kelleher, Kerry, Khandke, Kiran, Muszynska, Elwira, Loganzo, Frank, Rosfjord, Edward, Lucas, Judy, Kan, Zhengyan, Subramanyam, Chakrapani, O'Donnell, Christopher, Neri, Dario, Gerber, Hans-Peter, May, Chad, Sapra, Puja
Published in Molecular cancer therapeutics (06.09.2022)
Published in Molecular cancer therapeutics (06.09.2022)
Get full text
Journal Article
Long-term tumor regression induced by an antibody-drug conjugate that targets 5T4, an oncofetal antigen expressed on tumor-initiating cells
Sapra, Puja, Damelin, Marc, Dijoseph, John, Marquette, Kimberly, Geles, Kenneth G, Golas, Jonathon, Dougher, Maureen, Narayanan, Bitha, Giannakou, Andreas, Khandke, Kiran, Dushin, Russell, Ernstoff, Elana, Lucas, Judy, Leal, Mauricio, Hu, George, O'Donnell, Christopher J, Tchistiakova, Lioudmila, Abraham, Robert T, Gerber, Hans-Peter
Published in Molecular cancer therapeutics (01.01.2013)
Published in Molecular cancer therapeutics (01.01.2013)
Get full text
Journal Article
Abstract 818: NG-HER2 ADC (PF-06804103) is superior to trastuzumab emtansine in a mouse 'avatar' head-to-head clinical trial
Sung, Matthew S., Hopf, Christine, Upeslacis, Erik, Golas, Jonathon, Kaplan, Mark, Khandke, Kiran, Charati, Manoj, Kotch, Frank, Loganzo, Frank, Geles, Ken, Lucas, Judy, Gerber, Hans-Peter, Sapra, Puja, Rosfjord, Edward
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Get full text
Journal Article
Delineation of a Cellular Hierarchy in Lung Cancer Reveals an Oncofetal Antigen Expressed on Tumor-Initiating Cells
DAMELIN, Marc, GELES, Kenneth G, BEHRENS, Carmen, CHOE, Sung E, RIOS, Carol, GRUZAS, Janet, SRIDHARAN, Latha, DOUGHER, Maureen, KUNZ, Arthur, HAMANN, Philip R, EVANS, Deborah, ARMELLINO, Douglas, FOLLETTIE, Maximillian T, KHANDKE, Kiran, MARQUETTE, Kimberly, TCHISTIAKOVA, Lioudmila, BOGHAERT, Erwin R, ABRAHAM, Robert T, WISTUBA, Ignacio I, ZHOU, Bin-Bing S, PING YUAN, BAXTER, Michelle, GOLAS, Jonathon, DIJOSEPH, John F, KARNOUB, Maha, SHUGUANG HUANG, DIESL, Veronica
Published in Cancer research (Chicago, Ill.) (15.06.2011)
Published in Cancer research (Chicago, Ill.) (15.06.2011)
Get full text
Journal Article
Antibody-targeted chemotherapy with CMC-544: a CD22-targeted immunoconjugate of calicheamicin for the treatment of B-lymphoid malignancies
DiJoseph, John F., Armellino, Douglas C., Boghaert, Erwin R., Khandke, Kiran, Dougher, Maureen M., Sridharan, Latha, Kunz, Arthur, Hamann, Philip R., Gorovits, Boris, Udata, Chandrasekhar, Moran, Justin K., Popplewell, Andrew G., Stephens, Sue, Frost, Philip, Damle, Nitin K.
Published in Blood (01.03.2004)
Published in Blood (01.03.2004)
Get full text
Journal Article
Abstract 1830: Antibody-drug conjugates with modified linker-payloads overcome resistance to a trastuzumab-maytansinoid conjugate in multiple cultured tumor cell models
Tan, Xingzhi, Lu, Bingwen, Jin, Guixian, Wang, Fang, Myers, Jeremy, Musto, Sylvia, Lam, My-Hanh, Hu, William, Khandke, Kiran, Arndt, Kim, Gerber, Hans-Peter, Loganzo, Frank
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Get full text
Journal Article
Abstract 2059: In situ imaging of antibody drug conjugate (ADC) binding and pharmacodynamic biomarkers of response in models of human cancer
Golas, Jonathon, Hooper, Andrea T., Lucas, Justin, Jones, Heather, Nichols, Timothy, Khandke, Kiran, Charati, Manoj, Conant, Roger, Cinque, Michael, Lucas, Judy, Damelin, Marc, Geles, Ken, Teresa, Caiazzo, Loganzo, Frank, Sapra, Puja, Gerber, Hans-Peter, May, Chad
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Get full text
Journal Article
Abstract 5425: An anti-Ephrin-A4 calicheamicin conjugate effectively targets triple-negative breast and ovarian tumor-initiating cells to result in sustained tumor regression
Damelin, Marc, Bankovich, Alex, Park, Albert, Aguilar, Jorge, Anderson, Wade, Santaguida, Marianne, Fong, Sarah, Aujay, Monette, Khandke, Kiran, Pulito, Virginia, Ernstoff, Elana, Escarpe, Paul, Bernstein, Jeff, Pysz, Marybeth A., Zhong, Wenyan, Upeslacis, Erik, Lucas, Judy, Lucas, Justin, Nichols, Timothy, Loving, Kathryn, Foord, Orit, Hampl, Johannes, Stull, Robert, Barletta, Frank, Falahatpisheh, Hadi, Sapra, Puja, Gerber, Hans Peter, Dylla, Scott J.
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Get full text
Journal Article
Abstract 1241: Targeting the IL-13 receptor alpha 2 with novel antibody-drug conjugates for the treatment of cancer
Ma, Dangshe, Zhang, Haige, Jin, Fang, Charati, Manoj, Khandke, Kiran, Lucas, Judy, Follettie, Max, Tumey, L. Nathan, Gerber, Hans-Peter, Tchistiakova, Lioudmila, Sapra, Puja
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Get full text
Journal Article
Abstract 4629: Tumor cells selected for resistance to an antibody-drug conjugate retain sensitivity to ADCs with modified linkers and payloads
Tan, Xingzhi, Jin, Guixian, Myers, Jeremy, Diesl, Veronica, Follettie, Max, Lam, My-Hanh, Musto, Sylvia, Khandke, Kiran, Charati, Manoj, Graziani, Edmund, Maderna, Andreas, Subramanyam, Chakrapani, Koehn, Frank, Dushin, Russell, Arndt, Kim, O'Donnell, Christopher J., Gerber, Hans-Peter, Loganzo, Frank
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Get full text
Journal Article
Abstract 5471: Notch-antibody drug conjugates have a different mechanism of action than Notch signaling inhibitors and induce tumor regression
Geles, Kenneth G., Gao, Yijie, Sridharan, Latha, Giannakou, Andreas, Yamin, Ting-Ting, Golas, Jonathan, Charati, Manoj, Khandke, Kiran, Lucas, Judy, Maderna, Andreas, O'Donnell, Christopher J., Tchistiakova, Lioudmila, Gerber, Hans-Peter, Sapra, Puja
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Get full text
Journal Article
Abstract C161: Tumor cells selected for resistance to an antibody-drug conjugate modulate protein trafficking and signaling pathways
Tan, Xingzhi, Whitney, Lauren, Jin, Guixian, Myers, Jeremy, Diesl, Veronica, Follettie, Max, Musto, Sylvia, Jiang, Fan, Khandke, Kiran, Arndt, Kim, Gerber, Hans-Peter, Loganzo, Frank
Published in Molecular cancer therapeutics (12.11.2011)
Published in Molecular cancer therapeutics (12.11.2011)
Get full text
Journal Article
Abstract C117: Preclinical pharmacokinetics of an antibody-drug conjugate targeting 5T4
Leal, Mauricio, Wentland, Joann, Clark, Tracey, Zhang, Jenny, Marcek, John, Khandke, Kiran, DiJoseph, John, Lucas, Judy, Groeber, Elizabeth, Han, Xiaognag, Hu, George, Gerber, Hans-Peter, Sapra, Puja
Published in Molecular cancer therapeutics (12.11.2011)
Published in Molecular cancer therapeutics (12.11.2011)
Get full text
Journal Article
Abstract 2530: Long-term tumor regression induced by a novel antibody drug conjugate that targets 5T4, an oncofetal antigen expressed on tumor-initiating cells
Sapra, Puja, DiJoseph, John, Damelin, Marc, Dougher, Maureen, Narayanan, Bitha, Khandke, Kiran, Lucas, Judy, Golas, Jon, Tchistiakova, Lioudmila, Leal, Mauricio, Hu, George, Maderna, Andreas, Marquette, Kimberly, Loganzo, Frank, Dushin, Russell, O'Donnell, Christopher J., Abraham, Robert, Gerber, Hans-Peter
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Get full text
Journal Article
Abstract 4752: Preclinical development and translational research on a novel antibody-drug conjugate that targets 5T4, an oncofetal antigen expressed on tumor-initiating cells
Sapra, Puja, Damelin, Marc, Marquette, Kimberly, Geles, Kenneth G., Golas, Jonathon, Dougher, Maureen, Narayanan, Bitha, Giannakou, Andreas, Khandke, Kiran, Dushin, Russell, Ernstoff, Elana, Lucas, Judy, Leal, Mauricio, Hu, George, Betts, Alison, Haddish-Berhane, Nahor, Powell, Eric, Pirie-Shepherd, Steven, O'Donnell, Christopher, Tchistiakova, Lioudmila, Gerber, Hans-Peter, Marrinucci, Dena, Tucker, Eric
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Get full text
Journal Article