Engineering Protein-Secreting Plasma Cells by Homology-Directed Repair in Primary Human B Cells
Hung, King L., Meitlis, Iana, Hale, Malika, Chen, Chun-Yu, Singh, Swati, Jackson, Shaun W., Miao, Carol H., Khan, Iram F., Rawlings, David J., James, Richard G.
Published in Molecular therapy (07.02.2018)
Published in Molecular therapy (07.02.2018)
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Journal Article
Ex vivo engineered human plasma cells exhibit robust protein secretion and long-term engraftment in vivo
Cheng, Rene Yu-Hong, Hung, King L, Zhang, Tingting, Stoffers, Claire M, Ott, Andee R, Suchland, Emmaline R, Camp, Nathan D, Khan, Iram F, Singh, Swati, Yang, Ying-Jen, Rawlings, David J, James, Richard G
Published in Nature communications (16.10.2022)
Published in Nature communications (16.10.2022)
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Journal Article
Engineering of Human Pluripotent Stem Cells by AAV-mediated Gene Targeting
Khan, Iram F, Hirata, Roli K, Wang, Pei-Rong, Li, Yi, Kho, Jordan, Nelson, Angel, Huo, Yunwen, Zavaljevski, Maja, Ware, Carol, Russell, David W
Published in Molecular therapy (01.06.2010)
Published in Molecular therapy (01.06.2010)
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Journal Article
Normal Collagen and Bone Production by Gene-targeted Human Osteogenesis Imperfecta iPSCs
Deyle, David R, Khan, Iram F, Ren, Gaoying, Wang, Pei-Rong, Kho, Jordan, Schwarze, Ulrike, Russell, David W
Published in Molecular therapy (01.01.2012)
Published in Molecular therapy (01.01.2012)
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Journal Article
Efficient and sustained FOXP3 locus editing in hematopoietic stem cells as a therapeutic approach for IPEX syndrome
Singh, Swati, Pugliano, Cole M., Honaker, Yuchi, Laird, Aidan, DeGottardi, M. Quinn, Lopez, Ezra, Lachkar, Stefan, Stoffers, Claire, Sommer, Karen, Khan, Iram F., Rawlings, David J.
Published in Molecular therapy. Methods & clinical development (14.03.2024)
Published in Molecular therapy. Methods & clinical development (14.03.2024)
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Journal Article
Effective, safe, and sustained correction of murine XLA using a UCOE-BTK promoter-based lentiviral vector
Seymour, Brenda J., Singh, Swati, Certo, Hannah M., Sommer, Karen, Sather, Blythe D., Khim, Socheath, Clough, Courtnee, Hale, Malika, Pangallo, Joseph, Ryu, Byoung Y., Khan, Iram F., Adair, Jennifer E., Rawlings, David J.
Published in Molecular therapy. Methods & clinical development (12.03.2021)
Published in Molecular therapy. Methods & clinical development (12.03.2021)
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Journal Article
Efficient modification of CCR5 in primary human hematopoietic cells using a megaTAL nuclease and AAV donor template
Sather, Blythe D, Romano Ibarra, Guillermo S, Sommer, Karen, Curinga, Gabrielle, Hale, Malika, Khan, Iram F, Singh, Swati, Song, Yumei, Gwiazda, Kamila, Sahni, Jaya, Jarjour, Jordan, Astrakhan, Alexander, Wagner, Thor A, Scharenberg, Andrew M, Rawlings, David J
Published in Science translational medicine (30.09.2015)
Published in Science translational medicine (30.09.2015)
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Journal Article
High Efficiency CRISPR/Cas9-mediated Gene Editing in Primary Human T-cells Using Mutant Adenoviral E4orf6/E1b55k “Helper” Proteins
Gwiazda, Kamila S, Grier, Alexandra E, Sahni, Jaya, Burleigh, Stephen M, Martin, Unja, Yang, Julia G, Popp, Nicholas A, Krutein, Michelle C, Khan, Iram F, Jacoby, Kyle, Jensen, Michael C, Rawlings, David J, Scharenberg, Andrew M
Published in Molecular therapy (01.09.2016)
Published in Molecular therapy (01.09.2016)
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Journal Article
Successful treatment of canine leukocyte adhesion deficiency by foamy virus vectors
Russell, David W, Hickstein, Dennis D, Bauer, Thomas R, Allen, James M, Hai, Mehreen, Tuschong, Laura M, Khan, Iram F, Olson, Erik M, Adler, Rima L, Burkholder, Tanya H, Gu, Yu-chen
Published in Nature medicine (01.01.2008)
Published in Nature medicine (01.01.2008)
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Journal Article
Progressive engineering of a homing endonuclease genome editing reagent for the murine X-linked immunodeficiency locus
Wang, Yupeng, Khan, Iram F, Boissel, Sandrine, Jarjour, Jordan, Pangallo, Joseph, Thyme, Summer, Baker, David, Scharenberg, Andrew M, Rawlings, David J
Published in Nucleic acids research (02.06.2014)
Published in Nucleic acids research (02.06.2014)
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Journal Article
유전자 편집된 T 세포에서의 인간 FOXP3의 발현
SCHARENBERG ANDREW M, HONAKER YUCHI CHIANG, TORGERSON TROY, RAWLINGS DAVID J, KHAN IRAM F, SOMMER KAREN
Year of Publication 13.01.2021
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Year of Publication 13.01.2021
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DNA-PK inhibition enhances gene editing efficiency in HSPCs for CRISPR-based treatment of X-linked hyper IgM syndrome
Pugliano, Cole M., Berger, Mason, Ray, Roslyn M., Sapkos, Kai, Wu, Betty, Laird, Aidan, Ye, Yidian, Thomson, Daniel, DeGottardi, M. Quinn, Khan, Iram F., Tatiossian, Kristina, Miles, Brodie A., Aeschimann, Florian, Pasquier, Jerome, Kim, Mihee M., Rawlings, David J.
Published in Molecular therapy. Methods & clinical development (12.09.2024)
Published in Molecular therapy. Methods & clinical development (12.09.2024)
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Journal Article
569. Precision Editing of the WAS Locus via Homologous Recombination in Primary Human Hematopoietic Cells Mediated by Either TALEN or CRISPR/Cas Nucleases
Khan, Iram F., Wang, Yupeng, Clough, Courtnee, Singh, Swati, Hung, King, Rawlings, David J.
Published in Molecular therapy (01.05.2016)
Published in Molecular therapy (01.05.2016)
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Journal Article
132. Targeting the BTK Locus in Primary Human Hematopoietic Cells with TALENs and AAV Donor Template
Clough, Courtnee, Wang, Yupeng, Khan, Iram F., Singh, Swati, Hung, King, Rawlings, David J.
Published in Molecular therapy (01.05.2016)
Published in Molecular therapy (01.05.2016)
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Journal Article
334. Improved MegaTAL Endonuclease Engineering Strategy for Gene Modification Applications
Wang, Yupeng, Khan, Iram F., Clough, Courtnee, Scharenberg, Andrew M., Rawlings, David J.
Published in Molecular therapy (01.05.2015)
Published in Molecular therapy (01.05.2015)
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Journal Article
398. Site-Specific Introduction of Chimeric Antigen Receptors to Primary Human T Cells
Hale, Malika, Grier, Alexandra, Honaker, Yuchi, Ibarra, Guillermo S. Romano, Sommer, Karen, Khan, Iram F., Hasle, Nicholas, Sahni, Jaya, Lee, Baeckseung, Jarjour, Jordan, Astrakhan, Alexander, Scharenberg, Andrew M., Rawlings, David J.
Published in Molecular therapy (01.05.2016)
Published in Molecular therapy (01.05.2016)
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Journal Article
Expression of human FOXP3 in gene edited T cells
TORGERSON, Troy, RAWLINGS, David J, KHAN, Iram F, SCHARENBERG, Andrew M, SOMMER, Karen, HONAKER, Yuchi Chiang
Year of Publication 22.08.2024
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Year of Publication 22.08.2024
Patent