Selective Anti-Leishmanial Strathclyde Minor Groove Binders Using an N-Oxide Tail-Group Modification
Perieteanu, Marina C, McGee, Leah M C, Shaw, Craig D, MacMillan, Donna S, Khalaf, Abedawn I, Gillingwater, Kirsten, Beveridge, Rebecca, Carter, Katharine C, Suckling, Colin J, Scott, Fraser J
Published in International journal of molecular sciences (07.10.2022)
Published in International journal of molecular sciences (07.10.2022)
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Journal Article
Designing Anti-inflammatory Drugs from Parasitic Worms: A Synthetic Small Molecule Analogue of the Acanthocheilonema viteae Product ES-62 Prevents Development of Collagen-Induced Arthritis
Al-Riyami, Lamyaa, Pineda, Miguel A, Rzepecka, Justyna, Huggan, Judith K, Khalaf, Abedawn I, Suckling, Colin J, Scott, Fraser J, Rodgers, David T, Harnett, Margaret M, Harnett, William
Published in Journal of medicinal chemistry (27.12.2013)
Published in Journal of medicinal chemistry (27.12.2013)
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Journal Article
Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model
Giordani, Federica, Khalaf, Abedawn I, Gillingwater, Kirsten, Munday, Jane C, de Koning, Harry P, Suckling, Colin J, Barrett, Michael P, Scott, Fraser J
Published in Journal of medicinal chemistry (28.03.2019)
Published in Journal of medicinal chemistry (28.03.2019)
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Journal Article
Correction to “Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model”
Giordani, Federica, Khalaf, Abedawn I, Gillingwater, Kirsten, Munday, Jane C, de Koning, Harry P, Suckling, Colin J, Barrett, Michael P, Scott, Fraser J
Published in Journal of medicinal chemistry (23.12.2021)
Published in Journal of medicinal chemistry (23.12.2021)
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Journal Article
Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome
Rzepecka, Justyna, Pineda, Miguel A, Al-Riyami, Lamyaa, Rodgers, David T, Huggan, Judith K, Lumb, Felicity E, Khalaf, Abedawn I, Meakin, Paul J, Corbet, Marlene, Ashford, Michael L, Suckling, Colin J, Harnett, Margaret M, Harnett, William
Published in Journal of autoimmunity (01.06.2015)
Published in Journal of autoimmunity (01.06.2015)
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Journal Article
Truncated S-MGBs: towards a parasite-specific and low aggregation chemotype
Brooke, Daniel P, McGee, Leah M. C, Giordani, Federica, Cross, Jasmine M, Khalaf, Abedawn I, Irving, Craig, Gillingwater, Kirsten, Shaw, Craig D, Carter, Katharine C, Barrett, Michael P, Suckling, Colin J, Scott, Fraser J
Published in MedChemComm (18.08.2021)
Published in MedChemComm (18.08.2021)
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Journal Article
An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics
Scott, Fraser J., Khalaf, Abedawn I., Giordani, Federica, Wong, Pui Ee, Duffy, Sandra, Barrett, Michael, Avery, Vicky M., Suckling, Colin J.
Published in European journal of medicinal chemistry (30.06.2016)
Published in European journal of medicinal chemistry (30.06.2016)
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Journal Article
Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy
Hlaka, Lerato, Rosslee, Michael-Jon, Ozturk, Mumin, Kumar, Santosh, Parihar, Suraj P, Brombacher, Frank, Khalaf, Abedawn I, Carter, Katharine C, Scott, Fraser J, Suckling, Colin J, Guler, Reto
Published in Journal of antimicrobial chemotherapy (01.12.2017)
Published in Journal of antimicrobial chemotherapy (01.12.2017)
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Journal Article
Selective in vitro anti-cancer activity of non-alkylating minor groove binders
Nichol, Ryan J. O., Khalaf, Abedawn, Sooda, Kartheek, Hussain, Omar, Griffiths, Hollie B. S., Phillips, Roger, Javid, Farideh A., Suckling, Colin J., Allison, Simon J., Scott, Fraser J.
Published in MedChemComm (01.09.2019)
Published in MedChemComm (01.09.2019)
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Journal Article
Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1
Khalaf, Abedawn I, Huggan, Judith K, Suckling, Colin J, Gibson, Colin L, Stewart, Kirsten, Giordani, Federica, Barrett, Michael P, Wong, Pui Ee, Barrack, Keri L, Hunter, William N
Published in Journal of medicinal chemistry (14.08.2014)
Published in Journal of medicinal chemistry (14.08.2014)
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Journal Article
Synthetic analogues of the parasitic worm product ES-62 reduce disease development in in vivo models of lung fibrosis
Suckling, Colin J., Mukherjee, Sambuddho, Khalaf, Abedawn I., Narayan, Ashwini, Scott, Fraser J., Khare, Sonal, Dhakshinamoorthy, Saravanakumar, Harnett, Margaret M., Harnett, William
Published in Acta tropica (01.09.2018)
Published in Acta tropica (01.09.2018)
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Journal Article
An evaluation of Minor Groove Binders as anti-fungal and anti-mycobacterial therapeutics
Scott, Fraser J., Nichol, Ryan J.O., Khalaf, Abedawn I., Giordani, Federica, Gillingwater, Kirsten, Ramu, Soumya, Elliott, Alysha, Zuegg, Johannes, Duffy, Paula, Rosslee, Michael-Jon, Hlaka, Lerato, Kumar, Santosh, Ozturk, Mumin, Brombacher, Frank, Barrett, Michael, Guler, Reto, Suckling, Colin J.
Published in European journal of medicinal chemistry (18.08.2017)
Published in European journal of medicinal chemistry (18.08.2017)
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Journal Article
Selective anti-malarial minor groove binders
Scott, Fraser J., Khalaf, Abedawn I., Duffy, Sandra, Avery, Vicky M., Suckling, Colin J.
Published in Bioorganic & medicinal chemistry letters (15.07.2016)
Published in Bioorganic & medicinal chemistry letters (15.07.2016)
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Journal Article
Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties
Rzepecka, Justyna, Coates, Michelle L., Saggar, Moninder, Al-Riyami, Lamyaa, Coltherd, Jennifer, Tay, Hwee Kee, Huggan, Judith K., Janicova, Lucia, Khalaf, Abedawn I., Siebeke, Ivonne, Suckling, Colin J., Harnett, Margaret M., Harnett, William
Published in International journal for parasitology (01.08.2014)
Published in International journal for parasitology (01.08.2014)
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Journal Article
Correction: Truncated S-MGBs: towards a parasite-specific and low aggregation chemotype
Brooke, Daniel P, McGee, Leah M. C, Giordani, Federica, Cross, Jasmine M, Khalaf, Abedawn I, Irving, Craig, Gillingwater, Kirsten, Shaw, Craig D, Carter, Katharine C, Barrett, Michael P, Suckling, Colin J, Scott, Fraser J
Published in MedChemComm (15.12.2021)
Published in MedChemComm (15.12.2021)
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Journal Article
DNA Minor Groove Binders-Inspired by Nature
Khalaf, Abedawn Ibrahim, Al-Kadhimi, Ahmed A H, Ali, Jaafar H
Published in Acta chimica Slovenica (01.12.2016)
Published in Acta chimica Slovenica (01.12.2016)
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Journal Article
An evaluation of Minor Groove Binders as anti-lung cancer therapeutics
Scott, Fraser J., Puig-Sellart, Mireia, Khalaf, Abedawn I., Henderson, Catherine J., Westrop, Gareth, Watson, David G., Carter, Katharine, Grant, M. Helen, Suckling, Colin J.
Published in Bioorganic & medicinal chemistry letters (01.08.2016)
Published in Bioorganic & medicinal chemistry letters (01.08.2016)
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Journal Article
Antimicrobial Lexitropsins Containing Amide, Amidine, and Alkene Linking Groups
Anthony, Nahoum G, Breen, David, Clarke, Joanna, Donoghue, Gavin, Drummond, Allan J, Ellis, Elizabeth M, Gemmell, Curtis G, Helesbeux, Jean-Jacques, Hunter, Iain S, Khalaf, Abedawn I, Mackay, Simon P, Parkinson, John A, Suckling, Colin J, Waigh, Roger D
Published in Journal of medicinal chemistry (29.11.2007)
Published in Journal of medicinal chemistry (29.11.2007)
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Journal Article
A detailed binding free energy study of 2:1 ligand-DNA complex formation by experiment and simulation
Treesuwan, Witcha, Wittayanarakul, Kitiyaporn, Anthony, Nahoum G, Huchet, Guillaume, Alniss, Hasan, Hannongbua, Supa, Khalaf, Abedawn I, Suckling, Colin J, Parkinson, John A, Mackay, Simon P
Published in Physical chemistry chemical physics : PCCP (01.01.2009)
Published in Physical chemistry chemical physics : PCCP (01.01.2009)
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Journal Article
Recognition of the DNA Minor Groove by Thiazotropsin Analogues
Alniss , Hasan Y., Salvia, Marie-Virginie, Sadikov, Mykhailo, Golovchenko, Igor, Anthony, Nahoum G., Khalaf, Abedawn I., MacKay, Simon P., Suckling, Colin J., Parkinson, John A.
Published in Chembiochem : a European journal of chemical biology (05.09.2014)
Published in Chembiochem : a European journal of chemical biology (05.09.2014)
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Journal Article