Filgotinib versus placebo or adalimumab in patients with rheumatoid arthritis and inadequate response to methotrexate: a phase III randomised clinical trial
Combe, Bernard, Kivitz, Alan, Tanaka, Yoshiya, van der Heijde, Désirée, Simon, J Abraham, Baraf, Herbert S B, Kumar, Uma, Matzkies, Franziska, Bartok, Beatrix, Ye, Lei, Guo, Ying, Tasset, Chantal, Sundy, John S, Jahreis, Angelika, Genovese, Mark C, Mozaffarian, Neelufar, Landewé, Robert B M, Bae, Sang-Cheol, Keystone, Edward C, Nash, Peter
Published in Annals of the rheumatic diseases (01.07.2021)
Published in Annals of the rheumatic diseases (01.07.2021)
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Baricitinib versus Placebo or Adalimumab in Rheumatoid Arthritis
Taylor, Peter C, Keystone, Edward C, van der Heijde, Désirée, Weinblatt, Michael E, del Carmen Morales, Liliana, Reyes Gonzaga, Jaime, Yakushin, Sergey, Ishii, Taeko, Emoto, Kahaku, Beattie, Scott, Arora, Vipin, Gaich, Carol, Rooney, Terence, Schlichting, Douglas, Macias, William L, de Bono, Stephanie, Tanaka, Yoshiya
Published in The New England journal of medicine (16.02.2017)
Published in The New England journal of medicine (16.02.2017)
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A Phase IIb Study of ABT‐494, a Selective JAK‐1 Inhibitor, in Patients With Rheumatoid Arthritis and an Inadequate Response to Anti–Tumor Necrosis Factor Therapy
Kremer, Joel M., Emery, Paul, Camp, Heidi S., Friedman, Alan, Wang, Li, Othman, Ahmed A., Khan, Nasser, Pangan, Aileen L., Jungerwirth, Steven, Keystone, Edward C.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.12.2016)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.12.2016)
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Primary and secondary non-response: in need of operational definitions in observational studies
Vallejo-Yagüe, Enriqueta, Keystone, Edward C, Kandhasamy, Sreemanjari, Micheroli, Raphael, Finckh, Axel, Burden, Andrea Michelle
Published in Annals of the rheumatic diseases (01.08.2021)
Published in Annals of the rheumatic diseases (01.08.2021)
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Clinical evaluation of the efficacy of the P2X7 purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine
Keystone, Edward C, Wang, Millie M, Layton, Mark, Hollis, Sally, McInnes, Iain B
Published in Annals of the rheumatic diseases (01.10.2012)
Published in Annals of the rheumatic diseases (01.10.2012)
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Journal Article
TNFα modulates protein degradation pathways in rheumatoid arthritis synovial fibroblasts
Connor, Alison M, Mahomed, Nizar, Gandhi, Rajiv, Keystone, Edward C, Berger, Stuart A
Published in Arthritis research & therapy (14.03.2012)
Published in Arthritis research & therapy (14.03.2012)
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Journal Article
Safety and efficacy of baricitinib at 24 weeks in patients with rheumatoid arthritis who have had an inadequate response to methotrexate
Keystone, Edward C, Taylor, Peter C, Drescher, Edit, Schlichting, Douglas E, Beattie, Scott D, Berclaz, Pierre-Yves, Lee, Chin H, Fidelus-Gort, Rosanne K, Luchi, Monica E, Rooney, Terence P, Macias, William L, Genovese, Mark C
Published in Annals of the rheumatic diseases (01.02.2015)
Published in Annals of the rheumatic diseases (01.02.2015)
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The Proportion of Patients With Rheumatoid Arthritis Achieving ACR20/50/70; Consistent Patterns of a 60/40/20 as Demonstrated by a Systematic Review and Meta-analysis
Mokbel, Abir, Movahedi, Mohammad, Philippopoulos, Eleni, Ojani, Pantea, Keystone, Edward C
Published in Journal of clinical rheumatology (01.06.2023)
Published in Journal of clinical rheumatology (01.06.2023)
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Patient-reported outcomes from a phase 3 study of baricitinib versus placebo or adalimumab in rheumatoid arthritis: secondary analyses from the RA-BEAM study
Keystone, Edward C, Taylor, Peter C, Tanaka, Yoshiya, Gaich, Carol, DeLozier, Amy M, Dudek, Anna, Zamora, Jorge Velasco, Cobos, Jose Arturo Covarrubias, Rooney, Terence, Bono, Stephanie de, Arora, Vipin, Linetzky, Bruno, Weinblatt, Michael E
Published in Annals of the rheumatic diseases (01.11.2017)
Published in Annals of the rheumatic diseases (01.11.2017)
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Journal Article
Therapies for Active Rheumatoid Arthritis after Methotrexate Failure
O'Dell, James R, Mikuls, Ted R, Taylor, Thomas H, Ahluwalia, Vandana, Brophy, Mary, Warren, Stuart R, Lew, Robert A, Cannella, Amy C, Kunkel, Gary, Phibbs, Ciaran S, Anis, Aslam H, Leatherman, Sarah, Keystone, Edward
Published in The New England journal of medicine (25.07.2013)
Published in The New England journal of medicine (25.07.2013)
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Journal Article
Safety and Efficacy of Baricitinib Through 128 Weeks in an Open-label, Longterm Extension Study in Patients with Rheumatoid Arthritis
Keystone, Edward C, Genovese, Mark C, Schlichting, Douglas E, de la Torre, Inmaculada, Beattie, Scott D, Rooney, Terence P, Taylor, Peter C
Published in Journal of rheumatology (01.01.2018)
Published in Journal of rheumatology (01.01.2018)
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The comparative effectiveness of oral versus subcutaneous methotrexate for the treatment of early rheumatoid arthritis
Hazlewood, Glen S, Thorne, J Carter, Pope, Janet E, Lin, Daming, Tin, Diane, Boire, Gilles, Haraoui, Boulos, Hitchon, Carol A, Keystone, Edward C, Jamal, Shahin, Bykerk, Vivian P
Published in Annals of the rheumatic diseases (01.06.2016)
Published in Annals of the rheumatic diseases (01.06.2016)
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Journal Article
Long-term safety of rituximab in rheumatoid arthritis: 9.5-year follow-up of the global clinical trial programme with a focus on adverse events of interest in RA patients
van Vollenhoven, Ronald F, Emery, Paul, Bingham, Clifton O, Keystone, Edward C, Fleischmann, Roy M, Furst, Daniel E, Tyson, Nicola, Collinson, Neil, Lehane, Patricia B
Published in Annals of the rheumatic diseases (01.09.2013)
Published in Annals of the rheumatic diseases (01.09.2013)
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The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness
Siminovitch, Katherine A, Zhang, Jinyi, Zahir, Naima, Jiang, Qiuhong, Miliotis, Helen, Heyraud, Stephanie, Meng, Xianwang, Dong, Baoxia, Xie, Gang, Qiu, Frank, Hao, Zhenyue, McCulloch, Christopher A, Keystone, Edward C, Peterson, Alan C
Published in Nature genetics (01.09.2011)
Published in Nature genetics (01.09.2011)
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Discontinuation of tofacitinib and TNF inhibitors in patients with rheumatoid arthritis: analysis of pooled data from two registries in Canada
Movahedi, Mohammad, Choquette, Denis, Coupal, Louis, Cesta, Angela, Li, Xiuying, Keystone, Edward C, Bombardier, Claire, Investigators, OBRI
Published in BMJ open (06.03.2023)
Published in BMJ open (06.03.2023)
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Journal Article
Longterm safety of patients receiving rituximab in rheumatoid arthritis clinical trials
van Vollenhoven, Ronald F, Emery, Paul, Bingham, 3rd, Clifton O, Keystone, Edward C, Fleischmann, Roy, Furst, Daniel E, Macey, Katherine, Sweetser, Marianne, Kelman, Ariella, Rao, Ravi
Published in Journal of rheumatology (01.03.2010)
Published in Journal of rheumatology (01.03.2010)
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Health care costs of rheumatoid arthritis: A longitudinal population study
Tatangelo, Mark, Tomlinson, George, Paterson, J Michael, Keystone, Edward, Bansback, Nick, Bombardier, Claire
Published in PloS one (06.05.2021)
Published in PloS one (06.05.2021)
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Journal Article
Toward Defining Primary and Secondary Nonresponse in Rheumatoid Arthritis Patients Treated with Anti-TNF: Results from the BioTRAC and OBRI Registries
Keystone, Edward C, Rampakakis, Emmanouil, Movahedi, Mohammad, Cesta, Angela, Stutz, Melissa, Sampalis, John S, Nantel, Francois, Maslova, Karina, Bombardier, Claire
Published in Journal of rheumatology (01.04.2020)
Published in Journal of rheumatology (01.04.2020)
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