SER-109, an Investigational Microbiome Drug to Reduce Recurrence After Clostridioides difficile Infection: Lessons Learned From a Phase 2 Trial
McGovern, Barbara H, Ford, Christopher B, Henn, Matthew R, Pardi, Darrell S, Khanna, Sahil, Hohmann, Elizabeth L, O’Brien, Edward J, Desjardins, Christopher A, Bernardo, Patricia, Wortman, Jennifer R, Lombardo, Mary-Jane, Litcofsky, Kevin D, Winkler, Jonathan A, McChalicher, Christopher W J, Li, Sunny S, Tomlinson, Amelia D, Nandakumar, Madhumitha, Cook, David N, Pomerantz, Roger J, Auninš, John G, Trucksis, Michele
Published in Clinical infectious diseases (15.06.2021)
Published in Clinical infectious diseases (15.06.2021)
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Journal Article
SER-109, an Oral Microbiome Therapy for Recurrent Clostridioides difficile Infection
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Published in The New England journal of medicine (20.01.2022)
Published in The New England journal of medicine (20.01.2022)
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Journal Article
S177 The Impact of Age on Microbiome Diversity and Engraftment of Fecal Microbiota Spores, Live (FMS) in Patients With Recurrent Clostridioides difficile Infection
Gonzales-Luna, Anne J., Litcofsky, Kevin D., Straub, Timothy J., Hot, Dina, Hasson, Brooke, Sims, Matthew, Wortman, Jennifer R., Henn, Matthew R., McGovern, Barbara
Published in The American journal of gastroenterology (01.10.2023)
Published in The American journal of gastroenterology (01.10.2023)
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Journal Article
Impact of a Purified Microbiome Therapeutic on Abundance of Antimicrobial Resistance Genes in Patients With Recurrent Clostridioides difficile Infection
Straub, Timothy J, Lombardo, Mary-Jane, Bryant, Jessica A, Diao, Liyang, Lodise, Thomas P, Freedberg, Daniel E, Wortman, Jennifer R, Litcofsky, Kevin D, Hasson, Brooke R, McGovern, Barbara H, Ford, Christopher B, Henn, Matthew R
Published in Clinical infectious diseases (10.04.2024)
Published in Clinical infectious diseases (10.04.2024)
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Iterative plug-and-play methodology for constructing and modifying synthetic gene networks
Litcofsky, Kevin D, Afeyan, Raffi B, Krom, Russell J, Khalil, Ahmad S, Collins, James J
Published in Nature methods (01.11.2012)
Published in Nature methods (01.11.2012)
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NETWORK-BASED MICROBIAL COMPOSITIONS AND METHODS
DAVID N COOK, DAVID ARTHUR BERRY, MARY-JANE LOMBARDO MCKENZIE, JOHN GRANT AUNINS, MATTHEW R HENN, TOSHIRO K OHSUMI, KEVIN D LITCOFSKY, HAN JANG
Year of Publication 26.09.2019
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Year of Publication 26.09.2019
Patent
Su1606: ENGRAFTMENT OF INVESTIGATIONAL MICROBIOME THERAPEUTIC SER-109 IS DURABLE THROUGH 24 WEEKS IN A RANDOMIZED TRIAL (ECOSPOR III) FOR THE TREATMENT OF RECURRENT CLOSTRIDIOIDES DIFFICILE INFECTION
Desjardins, Christopher, Bryant, Jessica A., Walsh, Emily, Ford, Christopher B., Litcofsky, Kevin D., Wortman, Jennifer R., Henn, Matthew R.
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2022)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2022)
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110: IMPACT OF SER-109, AN INVESTIGATIONAL MICROBIOME THERAPEUTIC, ON STOOL FATTY ACID METABOLITES IN A PHASE 3 RANDOMIZED TRIAL (ECOSPOR III) FOR TREATMENT OF RECURRENT CLOSTRIDIOIDES DIFFICILE INFECTION (CDI)
Bryant, Jessica A., Vulic, Marin, Desjardins, Christopher, Ford, Christopher B., Litcofsky, Kevin D., Wortman, Jennifer R., Henn, Matthew R.
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2022)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2022)
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809 RAPID CONVERSION OF PRIMARY TO SECONDARY BILE ACIDS IN SUBJECTS WITH RECURRENT CLOSTRIDIOIDES DIFFICILE INFECTION (CDI) FOLLOWING SER-109, AN INVESTIGATIONAL MICROBIOME THERAPEUTIC
Bryant, Jessica A., Diao, Liyang, O'Brien, Edward J., Ford, Christopher B., Litcofsky, Kevin D., Wortman, Jennifer R., Henn, Matthew R.
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2021)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2021)
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Fr572 24-WEEK EFFICACY AND SAFETY DATA FROM ECOSPOR-III, A PHASE 3 DOUBLE-BLIND, PLACEBO-CONTROLLED RANDOMIZED TRIAL OF SER-109, AN INVESTIGATIONAL MICROBIOME THERAPEUTIC FOR TREATMENT OF RECURRENT CLOSTRIDIOIDES DIFFICILE INFECTION
Korman, Louis, Lashner, Bret, Kraft, Colleen, Sims, Matthew, Wang, Elaine E., Brady, Kelly, Ford, Christopher B., Lombardo, Mary-Jane, Litcofsky, Kevin D., Mahoney, Jennifer C., McChalicher, Christopher W., Winkler, Jonathan, Garant, Sarah, Mcgovern, Babara, McMullen, Erin, Henn, Matthew R., Trucksis, Michele, von Moltke, Lisa
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2021)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2021)
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Network-based microbial compositions and methods
Aunins, John Grant, Cook, David N, Ohsumi, Toshiro K, McKenzie, Mary-Jane Lombardo, Litcofsky, Kevin D, Henn, Matthew R, Zhang, Han, Berry, David Arthur
Year of Publication 06.06.2023
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Year of Publication 06.06.2023
Patent
NETWORK-BASED MICROBIAL COMPOSITIONS AND METHODS
OHSUMI, Toshiro K, HENN, Matthew R, MCKENZIE, Mary-Jane Lombardo, ZHANG, Han, AUNINS, John Grant, LITCOFSKY, Kevin D, COOK, David N, BERRY, David Arthur
Year of Publication 19.08.2021
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Year of Publication 19.08.2021
Patent
NETWORK-BASED MICROBIAL COMPOSITIONS AND METHODS
Berry, David, Aunins, John Grant, Cook, David N, Ohsumi, Toshiro K, McKenzie, Mary-Jane Lombardo, Litcofsky, Kevin D, Henn, Matthew R, Zhang, Han
Year of Publication 24.06.2021
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Year of Publication 24.06.2021
Patent
NETWORK-BASED MICROBIAL COMPOSITIONS AND METHODS
Berry, David, Aunins, John Grant, Cook, David N, Ohsumi, Toshiro K, McKenzie, Mary-Jane Lombardo, Litcofsky, Kevin D, Henn, Matthew R, Zhang, Han
Year of Publication 25.02.2021
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Year of Publication 25.02.2021
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Network-based microbial compositions and methods
Aunins, John Grant, Cook, David N, Ohsumi, Toshiro K, McKenzie, Mary-Jane Lombardo, Litcofsky, Kevin D, Henn, Matthew R, Zhang, Han, Berry, David Arthur
Year of Publication 05.01.2021
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Year of Publication 05.01.2021
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NETWORK-BASED MICROBIAL COMPOSITIONS AND METHODS
Berry, David, Aunins, John Grant, Cook, David N, Ohsumi, Toshiro K, McKenzie, Mary-Jane Lombardo, Litcofsky, Kevin D, Henn, Matthew R, Zhang, Han
Year of Publication 21.02.2019
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Year of Publication 21.02.2019
Patent
Network-Based Microbial Compositions and Methods
Aunins, John Grant, Cook, David N, Ohsumi, Toshiro K, McKenzie, Mary-Jane Lombardo, Litcofsky, Kevin D, Henn, Matthew R, Zhang, Han, Berry, David Arthur
Year of Publication 13.12.2018
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Year of Publication 13.12.2018
Patent
Network-based microbial compositions and methods
Berry, David, Aunins, John Grant, Cook, David N, Ohsumi, Toshiro K, McKenzie, Mary-Jane Lombardo, Litcofsky, Kevin D, Henn, Matthew R, Zhang, Han
Year of Publication 01.11.2018
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Year of Publication 01.11.2018
Patent
Network-based microbial compositions and methods
Berry, David, Aunins, John Grant, Cook, David N, Ohsumi, Toshiro K, McKenzie, Mary-Jane Lombardo, Litcofsky, Kevin D, Henn, Matthew R, Zhang, Han
Year of Publication 18.09.2018
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Year of Publication 18.09.2018
Patent
NETWORK-BASED MICROBIAL COMPOSITIONS AND METHODS
COOK, DAVID, N, LITCOFSKY, KEVIN, D, ZHANG, HAN, AUNINS, JOHN, GRANT, OHSUMI, TOSHIRO, K, HENN, MATTHEW, R, BERRY, DAVID, MCKENZIE, MARY-JANE, LOMBARDO
Year of Publication 14.09.2016
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Year of Publication 14.09.2016
Patent