Small-Angle Neutron Scattering Study of a Monoclonal Antibody Using Free-Energy Constraints
Clark, Nicholas J, Zhang, Hailiang, Krueger, Susan, Lee, Hyo Jin, Ketchem, Randal R, Kerwin, Bruce, Kanapuram, Sekhar R, Treuheit, Michael J, McAuley, Arnold, Curtis, Joseph E
Published in The journal of physical chemistry. B (14.11.2013)
Published in The journal of physical chemistry. B (14.11.2013)
Get full text
Journal Article
In Vivo Crystallization of Human IgG in the Endoplasmic Reticulum of Engineered Chinese Hamster Ovary (CHO) Cells
Hasegawa, Haruki, Wendling, John, He, Feng, Trilisky, Egor, Stevenson, Riki, Franey, Heather, Kinderman, Francis, Li, Gary, Piedmonte, Deirdre Murphy, Osslund, Timothy, Shen, Min, Ketchem, Randal R.
Published in The Journal of biological chemistry (03.06.2011)
Published in The Journal of biological chemistry (03.06.2011)
Get full text
Journal Article
A Central Nervous System-Restricted Isoform of the Interleukin-1 Receptor Accessory Protein Modulates Neuronal Responses to Interleukin-1
Smith, Dirk E., Lipsky, Brian P., Russell, Chris, Ketchem, Randal R., Kirchner, Jacqueline, Hensley, Kelly, Huang, Yangyang, Friedman, Wilma J., Boissonneault, Vincent, Plante, Marie-Michèle, Rivest, Serge, Sims, John E.
Published in Immunity (Cambridge, Mass.) (19.06.2009)
Published in Immunity (Cambridge, Mass.) (19.06.2009)
Get full text
Journal Article
High-Resolution Conformation of Gramicidin A in a Lipid Bilayer by Solid- State NMR
Ketchem, R. R., Hu, W., Cross, T. A.
Published in Science (American Association for the Advancement of Science) (10.09.1993)
Published in Science (American Association for the Advancement of Science) (10.09.1993)
Get full text
Journal Article
Anti-PCSK9 antibody pharmacokinetics and low-density lipoprotein-cholesterol pharmacodynamics in nonhuman primates are antigen affinity-dependent and exhibit limited sensitivity to neonatal Fc receptor-binding enhancement
Henne, Kirk R, Ason, Brandon, Howard, Monique, Wang, Wei, Sun, Jeonghoon, Higbee, Jared, Tang, Jie, Matsuda, Katherine C, Xu, Ren, Zhou, Lei, Chan, Joyce C Y, King, Chadwick, Piper, Derek E, Ketchem, Randal R, Michaels, Mark Leo, Jackson, Simon M, Retter, Marc W
Published in The Journal of pharmacology and experimental therapeutics (01.04.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2015)
Get full text
Journal Article
Four New Members Expand the Interleukin-1 Superfamily
Smith, Dirk E., Renshaw, Blair R., Ketchem, Randal R., Kubin, Marek, Garka, Kirsten E., Sims, John E.
Published in The Journal of biological chemistry (14.01.2000)
Published in The Journal of biological chemistry (14.01.2000)
Get full text
Journal Article
Disulfide Connectivity of Human Immunoglobulin G2 Structural Isoforms
Martinez, Theresa, Guo, Amy, Allen, Martin J, Han, Mei, Pace, Danielle, Jones, Jay, Gillespie, Ron, Ketchem, Randal R, Zhang, Yuling, Balland, Alain
Published in Biochemistry (Easton) (15.07.2008)
Published in Biochemistry (Easton) (15.07.2008)
Get full text
Journal Article
A Diversity of Antibody Epitopes Can Induce Signaling through the Erythropoietin Receptor
Lim, Ai Ching, Ketchem, Randal R, Borges, Luis, Carabeo, Teresa, Carter, Jane, Hoover, Joseph E, Hu, Zhonghua, Wittekind, Michael, Zhou, Hongxing, Mehlin, Christopher
Published in Biochemistry (Easton) (11.05.2010)
Published in Biochemistry (Easton) (11.05.2010)
Get full text
Journal Article
A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma
Smith, Dirk, Helgason, Hannes, Sulem, Patrick, Bjornsdottir, Unnur Steina, Lim, Ai Ching, Sveinbjornsson, Gardar, Hasegawa, Haruki, Brown, Michael, Ketchem, Randal R, Gavala, Monica, Garrett, Logan, Jonasdottir, Adalbjorg, Jonasdottir, Aslaug, Sigurdsson, Asgeir, Magnusson, Olafur T, Eyjolfsson, Gudmundur I, Olafsson, Isleifur, Onundarson, Pall Torfi, Sigurdardottir, Olof, Gislason, David, Gislason, Thorarinn, Ludviksson, Bjorn Runar, Ludviksdottir, Dora, Boezen, H Marike, Heinzmann, Andrea, Krueger, Marcus, Porsbjerg, Celeste, Ahluwalia, Tarunveer S, Waage, Johannes, Backer, Vibeke, Deichmann, Klaus A, Koppelman, Gerard H, Bønnelykke, Klaus, Bisgaard, Hans, Masson, Gisli, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F, Johnston, James A, Jonsdottir, Ingileif, Stefansson, Kari
Published in PLoS genetics (08.03.2017)
Published in PLoS genetics (08.03.2017)
Get full text
Journal Article
ADAM8 as a drug target in pancreatic cancer
Schlomann, Uwe, Koller, Garrit, Conrad, Catharina, Ferdous, Taheera, Golfi, Panagiota, Garcia, Adolfo Molejon, Höfling, Sabrina, Parsons, Maddy, Costa, Patricia, Soper, Robin, Bossard, Maud, Hagemann, Thorsten, Roshani, Rozita, Sewald, Norbert, Ketchem, Randal R., Moss, Marcia L., Rasmussen, Fred H., Miller, Miles A., Lauffenburger, Douglas A., Tuveson, David A., Nimsky, Christopher, Bartsch, Jörg W.
Published in Nature communications (28.01.2015)
Published in Nature communications (28.01.2015)
Get full text
Journal Article
Entanglement Model of Antibody Viscosity
Schmit, Jeremy D, He, Feng, Mishra, Shradha, Ketchem, Randal R, Woods, Christopher E, Kerwin, Bruce A
Published in The journal of physical chemistry. B (15.05.2014)
Published in The journal of physical chemistry. B (15.05.2014)
Get full text
Journal Article
A candidate antibody drug for prevention of malaria
Williams, Katherine L., Guerrero, Steve, Flores-Garcia, Yevel, Kim, Dongkyoon, Williamson, Kevin S., Siska, Christine, Smidt, Pauline, Jepson, Sofia Z., Li, Kan, Dennison, S. Moses, Mathis-Torres, Shamika, Chen, Xiaomu, Wille-Reece, Ulrike, MacGill, Randall S., Walker, Michael, Jongert, Erik, King, C. Richter, Ockenhouse, Christian, Glanville, Jacob, Moon, James E., Regules, Jason A., Tan, Yann Chong, Cavet, Guy, Lippow, Shaun M., Robinson, William H., Dutta, Sheetij, Tomaras, Georgia D., Zavala, Fidel, Ketchem, Randal R., Emerling, Daniel E.
Published in Nature medicine (2024)
Published in Nature medicine (2024)
Get full text
Journal Article
Biophysical Characterization of Structural Properties and Folding of Interleukin-1 Receptor Antagonist
Latypov, Ramil F., Harvey, Timothy S., Liu, Dingjiang, Bondarenko, Pavel V., Kohno, Tadahiko, Fachini, Roger A., Rosenfeld, Robert D., Ketchem, Randal R., Brems, David N., Raibekas, Andrei A.
Published in Journal of molecular biology (11.05.2007)
Published in Journal of molecular biology (11.05.2007)
Get full text
Journal Article
Framework Mutations of the 10-1074 bnAb Increase Conformational Stability, Manufacturability, and Stability While Preserving Full Neutralization Activity
Kerwin, Bruce A., Bennett, Chelsey, Brodsky, Yan, Clark, Rutilio, Floyd, J. Alaina, Gillespie, Alison, Mayer, Bryan T., McClure, Megan, Siska, Christine, Seaman, Michael S., Seaton, Kelly E., Shaver, Jeremy, Tomaras, Georgia D., Yates, Nicole L., Ketchem, Randal R.
Published in Journal of pharmaceutical sciences (01.01.2020)
Published in Journal of pharmaceutical sciences (01.01.2020)
Get full text
Journal Article
Native-State Solubility and Transfer Free Energy as Predictive Tools for Selecting Excipients to Include in Protein Formulation Development Studies
Banks, Douglas D., Latypov, Ramil F., Ketchem, Randal R., Woodard, Jon, Scavezze, Joanna L., Siska, Christine C., Razinkov, Vladimir I.
Published in Journal of pharmaceutical sciences (01.08.2012)
Published in Journal of pharmaceutical sciences (01.08.2012)
Get full text
Journal Article