HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis
Kessl, Jacques J., Kutluay, Sebla B., Townsend, Dana, Rebensburg, Stephanie, Slaughter, Alison, Larue, Ross C., Shkriabai, Nikoloz, Bakouche, Nordine, Fuchs, James R., Bieniasz, Paul D., Kvaratskhelia, Mamuka
Published in Cell (25.08.2016)
Published in Cell (25.08.2016)
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Journal Article
Allosteric inhibition of HIV-1 integrase activity
Engelman, Alan, Kessl, Jacques J, Kvaratskhelia, Mamuka
Published in Current opinion in chemical biology (01.06.2013)
Published in Current opinion in chemical biology (01.06.2013)
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Journal Article
A new class of multimerization selective inhibitors of HIV-1 integrase
Sharma, Amit, Slaughter, Alison, Jena, Nivedita, Feng, Lei, Kessl, Jacques J, Fadel, Hind J, Malani, Nirav, Male, Frances, Wu, Li, Poeschla, Eric, Bushman, Frederic D, Fuchs, James R, Kvaratskhelia, Mamuka
Published in PLoS pathogens (01.05.2014)
Published in PLoS pathogens (01.05.2014)
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Journal Article
Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation
Jurado, Kellie A., Wang, Hao, Slaughter, Alison, Feng, Lei, Kessl, Jacques J., Koh, Yasuhiro, Wang, Weifeng, Ballandras-Colas, Allison, Patel, Pratiq A., Fuchs, James R., Kvaratskhelia, Mamuka, Engelman, Alan
Published in Proceedings of the National Academy of Sciences - PNAS (21.05.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (21.05.2013)
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Journal Article
BET proteins promote efficient murine leukemia virus integration at transcription start sites
Sharma, Amit, Larue, Ross C., Plumb, Matthew R., Malani, Nirav, Male, Frances, Slaughter, Alison, Kessl, Jacques J., Shkriabai, Nikolozi, Coward, Elizabeth, Aiyer, Sriram S., Green, Patrick L., Wu, Li, Roth, Monica J., Bushman, Frederic D., Kvaratskhelia, Mamuka
Published in Proceedings of the National Academy of Sciences - PNAS (16.07.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (16.07.2013)
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Journal Article
Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors
Kessl, Jacques J., Jena, Nivedita, Koh, Yasuhiro, Taskent-Sezgin, Humeyra, Slaughter, Alison, Feng, Lei, de Silva, Suresh, Wu, Li, Le Grice, Stuart F.J., Engelman, Alan, Fuchs, James R., Kvaratskhelia, Mamuka
Published in The Journal of biological chemistry (11.05.2012)
Published in The Journal of biological chemistry (11.05.2012)
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Journal Article
The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors
Feng, Lei, Sharma, Amit, Slaughter, Alison, Jena, Nivedita, Koh, Yasuhiro, Shkriabai, Nikolozi, Larue, Ross C., Patel, Pratiq A., Mitsuya, Hiroaki, Kessl, Jacques J., Engelman, Alan, Fuchs, James R., Kvaratskhelia, Mamuka
Published in The Journal of biological chemistry (31.05.2013)
Published in The Journal of biological chemistry (31.05.2013)
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Journal Article
Dynamic Modulation of HIV-1 Integrase Structure and Function by Cellular Lens Epithelium-derived Growth Factor (LEDGF) Protein
McKee, Christopher J., Kessl, Jacques J., Shkriabai, Nikolozi, Dar, Mohd Jamal, Engelman, Alan, Kvaratskhelia, Mamuka
Published in The Journal of biological chemistry (14.11.2008)
Published in The Journal of biological chemistry (14.11.2008)
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Journal Article
Multi-Substituted Quinolines as HIV-1 Integrase Allosteric Inhibitors
Dinh, Long Phi, Sun, Jian, Glenn, Courtney D., Patel, Krunal, Pigza, Julie A., Donahue, Matthew G., Yet, Larry, Kessl, Jacques J.
Published in Viruses (01.07.2022)
Published in Viruses (01.07.2022)
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Journal Article
Indole-based allosteric inhibitors of HIV-1 integrase
Patel, Pratiq A., Kvaratskhelia, Nina, Mansour, Yara, Antwi, Janet, Feng, Lei, Koneru, Pratibha, Kobe, Mathew J., Jena, Nivedita, Shi, Guqin, Mohamed, Mosaad S., Li, Chenglong, Kessl, Jacques J., Fuchs, James R.
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
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Journal Article
A Critical Role of the C-terminal Segment for Allosteric Inhibitor-induced Aberrant Multimerization of HIV-1 Integrase
Shkriabai, Nikoloz, Dharmarajan, Venkatasubramanian, Slaughter, Alison, Kessl, Jacques J., Larue, Ross C., Feng, Lei, Fuchs, James R., Griffin, Patrick R., Kvaratskhelia, Mamuka
Published in The Journal of biological chemistry (19.09.2014)
Published in The Journal of biological chemistry (19.09.2014)
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Journal Article
FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75
Kessl, Jacques J., Li, Min, Ignatov, Michael, Shkriabai, Nikolozi, Eidahl, Jocelyn O., Feng, Lei, Musier-Forsyth, Karin, Craigie, Robert, Kvaratskhelia, Mamuka
Published in Nucleic acids research (01.11.2011)
Published in Nucleic acids research (01.11.2011)
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Journal Article
HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence
Zhao, Xue Zhi, Métifiot, Mathieu, Kiselev, Evgeny, Kessl, Jacques J, Maddali, Kasthuraiah, Marchand, Christophe, Kvaratskhelia, Mamuka, Pommier, Yves, Burke, Jr, Terrence R
Published in Molecules (Basel, Switzerland) (26.07.2018)
Published in Molecules (Basel, Switzerland) (26.07.2018)
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Journal Article
The Competitive Interplay between Allosteric HIV‑1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV‑1 Replication Adversely Affects Inhibitor Potency
Feng, Lei, Dharmarajan, Venkatasubramanian, Serrao, Erik, Hoyte, Ashley, Larue, Ross C, Slaughter, Alison, Sharma, Amit, Plumb, Matthew R, Kessl, Jacques J, Fuchs, James R, Bushman, Frederic D, Engelman, Alan N, Griffin, Patrick R, Kvaratskhelia, Mamuka
Published in ACS chemical biology (20.05.2016)
Published in ACS chemical biology (20.05.2016)
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Journal Article
Quinolines from the cyclocondensation of isatoic anhydride with ethyl acetoacetate: preparation of ethyl 4-hydroxy-2-methylquinoline-3-carboxylate and derivatives
Jentsch, Nicholas G, Hume, Jared D, Crull, Emily B, Beauti, Samer M, Pham, Amy H, Pigza, Julie A, Kessl, Jacques J, Donahue, Matthew G
Published in Beilstein journal of organic chemistry (28.09.2018)
Published in Beilstein journal of organic chemistry (28.09.2018)
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Journal Article
An Allosteric Mechanism for Inhibiting HIV-1 Integrase with a Small Molecule
Kessl, Jacques J, Eidahl, Jocelyn O, Shkriabai, Nikolozi, Zhao, Zhuojun, McKee, Christopher J, Hess, Sonja, Burke, Jr, Terrence R, Kvaratskhelia, Mamuka
Published in Molecular pharmacology (01.10.2009)
Published in Molecular pharmacology (01.10.2009)
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Journal Article
Molecular Basis for Atovaquone Binding to the Cytochrome bc1 Complex
Kessl, Jacques J., Lange, Benjamin B., Merbitz-Zahradnik, Torsten, Zwicker, Klaus, Hill, Philip, Meunier, Brigitte, Pálsdóttir, Hildur, Hunte, Carola, Meshnick, Steve, Trumpower, Bernard L.
Published in The Journal of biological chemistry (15.08.2003)
Published in The Journal of biological chemistry (15.08.2003)
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Journal Article
Subunit-specific Protein Footprinting Reveals Significant Structural Rearrangements and a Role for N-terminal Lys-14 of HIV-1 Integrase during Viral DNA Binding
Zhao, Zhuojun, McKee, Christopher J., Kessl, Jacques J., Santos, Webster L., Daigle, Janet E., Engelman, Alan, Verdine, Gregory, Kvaratskhelia, Mamuka
Published in The Journal of biological chemistry (29.02.2008)
Published in The Journal of biological chemistry (29.02.2008)
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Journal Article
Cytochrome b Mutations That Modify the Ubiquinol-binding Pocket of the Cytochrome bc1 Complex and Confer Anti-malarial Drug Resistance in Saccharomyces cerevisiae
Kessl, Jacques J., Ha, Kevin H., Merritt, Anne K., Lange, Benjamin B., Hill, Philip, Meunier, Brigitte, Meshnick, Steven R., Trumpower, Bernard L.
Published in The Journal of biological chemistry (29.04.2005)
Published in The Journal of biological chemistry (29.04.2005)
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