A New Class of Synthetic Type-B Polycyclic Polyprenylated Acylphloroglucinols (PPAP-B) Overcomes Venetoclax-Resistance in Acute Myeloid Leukemia (AML)
Kampa, Leonie Elisabeth, Bleisch, Anton, Peslalz, Philipp, Schittenhelm, Marcus Matthias, Plietker, Bernd, Kampa-Schittenhelm, Kerstin Maria
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
ASPP2 k, a Dominant-Negative Splicing Variant of the Apoptosis-Stimulating Protein of p53-2 (ASPP2), Modulates Treatment Response Towards BCL-Signaling Inhibitors in Acute Myeloid Leukemia
Schittenhelm, Marcus M., Tsintari, Vasileia, Fröhlich, Rebecca, Kampa-Schittenhelm, Kerstin Maria
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
Attenuation of the Apoptosis Stimulating Protein of TP53-1 (ASPP1) Is a Predictive Marker for Therapy Resistance and Overall Survival in Acute Myeloid Leukemia (AML)
Schittenhelm, Marcus M., Kaiser, Max, Tsintari, Vasileia, Blumenstock, Gunnar, Györffy, Balazs, Kampa-Schittenhelm, Kerstin Maria
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Overexpression of Oncogenic Inhibitory-ASPP (inhibitor of apoptosis stimulating protein of p53) Results in Therapy Resistance and Adverse Outcome in AML
Schittenhelm, Marcus Matthias, Bajrami Saipi, Mihada, Blumenstock, Gunnar, Valk, Peter JM, Györffy, Balazs, Kampa-Schittenhelm, Kerstin Maria
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Quizartinib (AC220) is a potent second generation class III tyrosine kinase inhibitor that displays a distinct inhibition profile against mutant-FLT3, -PDGFRA and -KIT isoforms
Kampa-Schittenhelm, Kerstin Maria, Heinrich, Michael Charles, Akmut, Figen, Döhner, Hartmut, Döhner, Konstanze, Schittenhelm, Marcus Matthias
Published in Molecular cancer (07.03.2013)
Published in Molecular cancer (07.03.2013)
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Oncogenic Splicing of the Apoptosis-Stimulating Protein of p53-2 (ASPP2) Is an Initiating Step in Leukemogenesis Facilitating Acquisition of Structural Genomic Mutations
Kampa-Schittenhelm, Kerstin Maria, Mau-Holzmann, Ulrike, Lopez, Charles, Schittenhelm, Marcus M.
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Journal Article
Dysregulation of the ASPP Protein Family (Apoptosis Stimulating Proteins of TP53) Is a Common Feature in High-Risk Acute Myeloid Leukemia (AML)
Kampa-Schittenhelm, Kerstin Maria, Kaiser, Max, Bajrami Saipi, Mihada, Walter, Bianca, Blumenstock, Gunnar, Kanz, Lothar, Schittenhelm, Marcus M
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Journal Article
Dronabinol has preferential antileukemic activity in acute lymphoblastic and myeloid leukemia with lymphoid differentiation patterns
Kampa-Schittenhelm, Kerstin Maria, Salitzky, Olaf, Akmut, Figen, Illing, Barbara, Kanz, Lothar, Salih, Helmut Rainer, Schittenhelm, Marcus Matthias
Published in BMC cancer (16.01.2016)
Published in BMC cancer (16.01.2016)
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Attenuation of Apoptosis-Stimulating Protein of p53-2 (ASPP2) Promotes IL-3-Independent Growth and Enhances Cytogenetic Abnormalities after Gamma-Irradiation in Mouse Hematopoietic Cells - Mimicking Early Leukemogenesis of Therapy-Associated Human AML
Kampa-Schittenhelm, Kerstin Maria, Mau-Holzmann, Ulrike, Kanz, Lothar, Lopez, Charles, Schittenhelm, Marcus M
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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Journal Article
Crenolanib is a type I tyrosine kinase inhibitor that inhibits mutant KIT D816 isoforms prevalent in systemic mastocytosis and core binding factor leukemia
Kampa-Schittenhelm, Kerstin Maria, Frey, Julia, Haeusser, Lara A, Illing, Barbara, Pavlovsky, Ashly A, Blumenstock, Gunnar, Schittenhelm, Marcus Matthias
Published in Oncotarget (10.10.2017)
Published in Oncotarget (10.10.2017)
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Journal Article
Cell cycle-dependent activity of the novel dual PI3K-MTORC1/2 inhibitor NVP-BGT226 in acute leukemia
Kampa-Schittenhelm, Kerstin Maria, Heinrich, Michael Charles, Akmut, Figen, Rasp, Katharina Henriette, Illing, Barbara, Döhner, Hartmut, Döhner, Konstanze, Schittenhelm, Marcus Matthias
Published in Molecular cancer (24.05.2013)
Published in Molecular cancer (24.05.2013)
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Journal Article
Epigenetic Upregulation of the O-Linked Beta-N-Acetylglucosamine Transferase (OGT) in Response to Dronabinol Results in Antileukemic Efficacy In Vivo
Kampa-Schittenhelm, Kerstin Maria, Buehring, Hans-Joerg, Bonin, Michael, Vogel, Wichard, Kanz, Lothar, Haverkamp, Thomas, Schittenhelm, Marcus M
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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Journal Article
Alternative splicing of the tumor suppressor ASPP2 results in a stress-inducible, oncogenic isoform prevalent in acute leukemia
Schittenhelm, Marcus Matthias, Walter, Bianca, Tsintari, Vasileia, Federmann, Birgit, Bajrami Saipi, Mihada, Akmut, Figen, Illing, Barbara, Mau-Holzmann, Ulrike, Fend, Falko, Lopez, Charles Darin, Kampa-Schittenhelm, Kerstin Maria
Published in EBioMedicine (01.04.2019)
Published in EBioMedicine (01.04.2019)
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Journal Article
Alternative splicing of the tumor suppressor ASPP2 results in a stress-inducible, oncogenic isoform prevalent in acute leukemiaResearch in context
Marcus Matthias Schittenhelm, Bianca Walter, Vasileia Tsintari, Birgit Federmann, Mihada Bajrami Saipi, Figen Akmut, Barbara Illing, Ulrike Mau-Holzmann, Falko Fend, Charles Darin Lopez, Kerstin Maria Kampa-Schittenhelm
Published in EBioMedicine (01.04.2019)
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Published in EBioMedicine (01.04.2019)
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