The molecular basis of JAK/STAT inhibition by SOCS1
Liau, Nicholas P. D., Laktyushin, Artem, Lucet, Isabelle S., Murphy, James M., Yao, Shenggen, Whitlock, Eden, Callaghan, Kimberley, Nicola, Nicos A., Kershaw, Nadia J., Babon, Jeffrey J.
Published in Nature communications (19.04.2018)
Published in Nature communications (19.04.2018)
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Suppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity
Babon, Jeffrey J., Kershaw, Nadia J., Murphy, James M., Varghese, Leila N., Laktyushin, Artem, Young, Samuel N., Lucet, Isabelle S., Norton, Raymond S., Nicola, Nicos A.
Published in Immunity (Cambridge, Mass.) (24.02.2012)
Published in Immunity (Cambridge, Mass.) (24.02.2012)
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A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity
Liang, Shuwei, Tran, Eric, Du, Xin, Dong, Jiajun, Sudholz, Harrison, Chen, Hao, Qu, Zihan, Huntington, Nicholas D., Babon, Jeffrey J., Kershaw, Nadia J., Zhang, Zhong-Yin, Baell, Jonathan B., Wiede, Florian, Tiganis, Tony
Published in Nature communications (27.07.2023)
Published in Nature communications (27.07.2023)
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SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition
Kershaw, Nadia J, Murphy, James M, Liau, Nicholas P D, Varghese, Leila N, Laktyushin, Artem, Whitlock, Eden L, Lucet, Isabelle S, Nicola, Nicos A, Babon, Jeffrey J
Published in Nature structural & molecular biology (01.04.2013)
Published in Nature structural & molecular biology (01.04.2013)
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Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern
Pfeffer, Inga, Brewitz, Lennart, Krojer, Tobias, Jensen, Sacha A., Kochan, Grazyna T., Kershaw, Nadia J., Hewitson, Kirsty S., McNeill, Luke A., Kramer, Holger, Münzel, Martin, Hopkinson, Richard J., Oppermann, Udo, Handford, Penny A., McDonough, Michael A., Schofield, Christopher J.
Published in Nature communications (28.10.2019)
Published in Nature communications (28.10.2019)
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Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK
Morris, Rhiannon, Zhang, Yaoyuan, Ellyard, Julia I., Vinuesa, Carola G., Murphy, James M., Laktyushin, Artem, Kershaw, Nadia J., Babon, Jeffrey J.
Published in Nature communications (20.10.2021)
Published in Nature communications (20.10.2021)
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The Role of LNK (SH2B3) in the Regulation of JAK-STAT Signalling in Haematopoiesis
Morris, Rhiannon, Butler, Liesl, Perkins, Andrew, Kershaw, Nadia J, Babon, Jeffrey J
Published in Pharmaceuticals (Basel, Switzerland) (24.12.2021)
Published in Pharmaceuticals (Basel, Switzerland) (24.12.2021)
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Regulation of Janus kinases by SOCS proteins
Kershaw, Nadia J, Murphy, James M, Lucet, Isabelle S, Nicola, Nicos A, Babon, Jeffrey J
Published in Biochemical Society transactions (01.08.2013)
Published in Biochemical Society transactions (01.08.2013)
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Cryo-EM structure of the extracellular domain of murine Thrombopoietin Receptor in complex with Thrombopoietin
Sarson-Lawrence, Kaiseal T. G., Hardy, Joshua M., Iaria, Josephine, Stockwell, Dina, Behrens, Kira, Saiyed, Tamanna, Tan, Cyrus, Jebeli, Leila, Scott, Nichollas E., Dite, Toby A., Nicola, Nicos A., Leis, Andrew P., Babon, Jeffrey J., Kershaw, Nadia J.
Published in Nature communications (07.02.2024)
Published in Nature communications (07.02.2024)
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Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands
Linossi, Edmond M., Li, Kunlun, Veggiani, Gianluca, Tan, Cyrus, Dehkhoda, Farhad, Hockings, Colin, Calleja, Dale J., Keating, Narelle, Feltham, Rebecca, Brooks, Andrew J., Li, Shawn S., Sidhu, Sachdev S., Babon, Jeffrey J., Kershaw, Nadia J., Nicholson, Sandra E.
Published in Nature communications (02.12.2021)
Published in Nature communications (02.12.2021)
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Author Correction: Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands
Linossi, Edmond M., Li, Kunlun, Veggiani, Gianluca, Tan, Cyrus, Dehkhoda, Farhad, Hockings, Colin, Calleja, Dale J., Keating, Narelle, Feltham, Rebecca, Brooks, Andrew J., Li, Shawn S., Sidhu, Sachdev S., Babon, Jeffrey J., Kershaw, Nadia J., Nicholson, Sandra E.
Published in Nature communications (01.12.2023)
Published in Nature communications (01.12.2023)
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Notch ligand delta-like1: X-ray crystal structure and binding affinity
Kershaw, Nadia J, Church, Nicole L, Griffin, Michael D W, Luo, Cindy S, Adams, Timothy E, Burgess, Antony W
Published in Biochemical journal (15.05.2015)
Published in Biochemical journal (15.05.2015)
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Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis
Srivastava, Monika, Duan, Guowen, Kershaw, Nadia J., Athanasopoulos, Vicki, Yeo, Janet H. C., Ose, Toyoyuki, Hu, Desheng, Brown, Simon H. J., Jergic, Slobodan, Patel, Hardip R., Pratama, Alvin, Richards, Sashika, Verma, Anil, Jones, E. Yvonne, Heissmeyer, Vigo, Preiss, Thomas, Dixon, Nicholas E., Chong, Mark M. W., Babon, Jeffrey J., Vinuesa, Carola G.
Published in Nature communications (20.02.2015)
Published in Nature communications (20.02.2015)
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SOCS2 regulation of growth hormone signaling requires a canonical interaction with phosphotyrosine
Li, Kunlun, Meza Guzman, Lizeth G, Whitehead, Lachlan, Leong, Evelyn, Kueh, Andrew, Alexander, Warren S, Kershaw, Nadia J, Babon, Jeffrey J, Doggett, Karen, Nicholson, Sandra E
Published in Bioscience reports (01.12.2022)
Published in Bioscience reports (01.12.2022)
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Crystal structure of the TRIM25 B30.2 (PRYSPRY) domain: a key component of antiviral signalling
D'Cruz, Akshay A, Kershaw, Nadia J, Chiang, Jessica J, Wang, May K, Nicola, Nicos A, Babon, Jeffrey J, Gack, Michaela U, Nicholson, Sandra E
Published in Biochemical journal (01.12.2013)
Published in Biochemical journal (01.12.2013)
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Context-restricted PD-(L)1 checkpoint agonism by CTLA4-Ig therapies inhibits T cell activity
Oxley, Ethan P., Kershaw, Nadia J., Louis, Cynthia, Goodall, Katharine J., Garwood, Maximilian M., Jee Ho, Skye Min, Voo, Veronica T.F., Park, Hae-Young, Iaria, Josephine, Wong, Lilian L.L., Lebenbaum, Ariel G., Wiranata, Stephanie, Pang, Ee Shan, Edwards, Emily S.J., D’Silva, Damian B., Hansen, Jacinta, van Zelm, Menno C., O’Keeffe, Meredith, Hogarth, P. Mark, Haynes, Nicole M., Huntington, Nicholas D., Wicks, Ian P., Dickins, Ross A.
Published in Cell reports (Cambridge) (22.10.2024)
Published in Cell reports (Cambridge) (22.10.2024)
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Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation
Scotti, John S., Leung, Ivanhoe K. H., Ge, Wei, Bentley, Michael A., Paps, Jordi, Kramer, Holger B., Lee, Joongoo, Aik, WeiShen, Choi, Hwanho, Paulsen, Steinar M., Bowman, Lesley A. H., Loik, Nikita D., Horita, Shoichiro, Ho, Chia-hua, Kershaw, Nadia J., Tang, Christoph M., Claridge, Timothy D. W., Preston, Gail M., McDonough, Michael A., Schofield, Christopher J.
Published in Proceedings of the National Academy of Sciences - PNAS (16.09.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (16.09.2014)
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JAK1 Takes a FERM Hold of Type II Cytokine Receptors
Babon, Jeffrey J., Liau, Nicholas P.D., Kershaw, Nadia J.
Published in Structure (London) (07.06.2016)
Published in Structure (London) (07.06.2016)
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