Human anti-macrophage migration inhibitory factor antibodies inhibit growth of human prostate cancer cells in vitro and in vivo
Hussain, Filza, Freissmuth, Michael, Völkel, Dirk, Thiele, Michael, Douillard, Patrice, Antoine, Gerhard, Thurner, Patrick, Ehrlich, Hartmut, Schwarz, Hans-Peter, Scheiflinger, Friedrich, Kerschbaumer, Randolf J
Published in Molecular cancer therapeutics (01.07.2013)
Published in Molecular cancer therapeutics (01.07.2013)
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Journal Article
Optimization of an Antibody Light Chain Framework Enhances Expression, Biophysical Properties and Pharmacokinetics
Douillard, Patrice, Freissmuth, Michael, Antoine, Gerhard, Thiele, Michael, Fleischanderl, Daniel, Matthiessen, Peter, Voelkel, Dirk, Kerschbaumer, Randolf J., Scheiflinger, Friedrich, Sabarth, Nicolas
Published in Antibodies (Basel) (06.09.2019)
Published in Antibodies (Basel) (06.09.2019)
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Journal Article
Preclinical Evaluation of ON203, A Novel Bioengineered mAb Targeting Oxidized Macrophage Migration Inhibitory Factor as an Anticancer Therapeutic
Rossmueller, Gregor, Mirkina, Irina, Maurer, Barbara, Hoeld, Verena, Mayer, Julia, Thiele, Michael, Kerschbaumer, Randolf J, Schinagl, Alexander
Published in Molecular cancer therapeutics (04.05.2023)
Published in Molecular cancer therapeutics (04.05.2023)
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Journal Article
Pretargeted Radioimmunotherapy with the Novel Anti-oxMIF/HSG Bispecific Antibody ON105 Results in Significant Tumor Regression in Murine Models of Cancer
Puchol Tarazona, Alejandro A, Schinagl, Alexander, Mirkina, Irina, Rossmueller, Gregor, Kerschbaumer, Randolf J, Bachmann, Friedmund, Thiele, Michael
Published in Molecular cancer therapeutics (04.09.2024)
Published in Molecular cancer therapeutics (04.09.2024)
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Journal Article
Role of the Cysteine 81 Residue of Macrophage Migration Inhibitory Factor as a Molecular Redox Switch
Schinagl, Alexander, Kerschbaumer, Randolf J, Sabarth, Nicolas, Douillard, Patrice, Scholz, Peter, Voelkel, Dirk, Hollerweger, Julia C, Goettig, Peter, Brandstetter, Hans, Scheiflinger, Friedrich, Thiele, Michael
Published in Biochemistry (Easton) (06.03.2018)
Published in Biochemistry (Easton) (06.03.2018)
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Journal Article
Oxidized macrophage migration inhibitory factor is a potential new tissue marker and drug target in cancer
Schinagl, Alexander, Thiele, Michael, Douillard, Patrice, Völkel, Dirk, Kenner, Lukas, Kazemi, Zahra, Freissmuth, Michael, Scheiflinger, Friedrich, Kerschbaumer, Randolf J
Published in Oncotarget (08.11.2016)
Published in Oncotarget (08.11.2016)
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Journal Article
Selective Targeting of a Disease-Related Conformational Isoform of Macrophage Migration Inhibitory Factor Ameliorates Inflammatory Conditions
Thiele, Michael, Kerschbaumer, Randolf J, Tam, Frederick W K, Völkel, Dirk, Douillard, Patrice, Schinagl, Alexander, Kühnel, Harald, Smith, Jennifer, McDaid, John P, Bhangal, Gurjeet, Yu, Mei-Ching, Pusey, Charles D, Cook, H Terence, Kovarik, Josef, Magelky, Erica, Bhan, Atul, Rieger, Manfred, Mudde, Geert C, Ehrlich, Hartmut, Jilma, Bernd, Tilg, Herbert, Moschen, Alexander, Terhorst, Cox, Scheiflinger, Friedrich
Published in The Journal of immunology (1950) (01.09.2015)
Published in The Journal of immunology (1950) (01.09.2015)
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Journal Article
Neutralization of Macrophage Migration Inhibitory Factor (MIF) by Fully Human Antibodies Correlates with Their Specificity for the β-Sheet Structure of MIF
Kerschbaumer, Randolf J., Rieger, Manfred, Völkel, Dirk, Le Roy, Didier, Roger, Thierry, Garbaraviciene, Jurate, Boehncke, Wolf-Henning, Müllberg, Jürgen, Hoet, Rene M., Wood, Clive R., Antoine, Gerhard, Thiele, Michael, Savidis-Dacho, Helga, Dockal, Michael, Ehrlich, Hartmut, Calandra, Thierry, Scheiflinger, Friedrich
Published in The Journal of biological chemistry (02.03.2012)
Published in The Journal of biological chemistry (02.03.2012)
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Journal Article
Pharmacokinetics, disease-modifying activity, and safety of an experimental therapeutic targeting an immunological isoform of macrophage migration inhibitory factor, in rat glomerulonephritis
Höllriegl, Werner, Bauer, Alexander, Baumgartner, Bernhard, Dietrich, Barbara, Douillard, Patrice, Kerschbaumer, Randolf J., Höbarth, Gerald, McKee, Jeffrey S., Schinagl, Alexander, Tam, Frederick W.K., Thiele, Michael, Weber, Alfred, Wolfsegger, Martin, Turecek, Marietta, Muchitsch, Eva-Maria, Scheiflinger, Friedrich, Glantschnig, Helmut
Published in European journal of pharmacology (05.02.2018)
Published in European journal of pharmacology (05.02.2018)
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Journal Article
An Antibody Specific for Coagulation Factor IX Enhances the Activity of the Intrinsic Factor X-activating Complex
Kerschbaumer, Randolf J., Riedrich, Klaudia, Kral, Martina, Varadi, Katalin, Dorner, Friedrich, Rosing, Jan, Scheiflinger, Friedrich
Published in The Journal of biological chemistry (24.09.2004)
Published in The Journal of biological chemistry (24.09.2004)
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Journal Article
Higher expression of fab antibody fragments in a CHO cell line at reduced temperature
Schatz, Simone M., Kerschbaumer, Randolf J., Gerstenbauer, Gabriele, Kral, Martina, Dorner, Friedrich, Scheiflinger, Friedrich
Published in Biotechnology and bioengineering (20.11.2003)
Published in Biotechnology and bioengineering (20.11.2003)
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Journal Article
Single-Chain Fv Fusion Proteins Suitable as Coating and Detecting Reagents in a Double Antibody Sandwich Enzyme-Linked Immunosorbent Assay
Kerschbaumer, Randolf J., Hirschl, Sonja, Kaufmann, Andrea, Ibl, Martin, Koenig, Renate, Himmler, Gottfried
Published in Analytical biochemistry (01.07.1997)
Published in Analytical biochemistry (01.07.1997)
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Journal Article
Fully recombinant enzyme-linked immunosorbent assays using genetically engineered single-chain antibody fusion proteins for detection of Citrus tristeza virus
TERRADA, Estela, KERSCHBAUMER, Randolf J, GIUNTA, Giuseppe, GALEFFI, Patrizia, HIMMLER, Gottfried, CAMBRA, Mariano
Published in Phytopathology (01.12.2000)
Published in Phytopathology (01.12.2000)
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Journal Article
Abstract 313: Novel bioengineered monoclonal antibodies targeting oxidized macrophage migration inhibitory factor as anti-cancer therapeutics and companion diagnostics
Schinagl, Alexander, Thiele, Michael, Mirkina, Irina, Rossmueller, Gregor, Tarazona, Alejandro A. Puchol, Kerschbaumer, Randolf J.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Abstract 4841: Oxidized macrophage migration inhibitory factor (oxMIF) expressed by tumor stroma and tumor cells, contributes to tumor growth
Schinagl, Alexander, Hagemann, Thorsten, Douillard, Patrice, Thiele, Michael, Voelkel, Dirk, Freissmuth, Michael, Scheiflinger, Friedrich, Kerschbaumer, Randolf J.
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Abstract A181: Oxidized macrophage migration inhibitory factor (oxMIF) is a previously unrecognized, disease-related isoform of MIF and a potential new drug target in cancer
Thiele, Michael, Douillard, Patrice, Voelkel, Dirk, Hagemann, Thorsten, Freissmuth, Michael, Ehrlich, Hartmut, Scheiflinger, Friedrich, Kerschbaumer, Randolf J.
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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Journal Article
Anti-Factor IX Antibodies Displaying FVIIIa-Like Activity
Kerschbaumer, Randolf J., Dockal, Michael, Jan, Rosing, Scheiflinger, Fritz
Published in Blood (16.11.2006)
Published in Blood (16.11.2006)
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Journal Article
OXMIF AS A DIAGNOSTIC MARKER
KERSCHBAUMER, Randolf, J, VOELKEL, Dirk, DOUILLARD, Patrice, SCHEIFLINGER, Friedrich, THIELE, Michael
Year of Publication 05.05.2021
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Year of Publication 05.05.2021
Patent
pSKAP/S: An Expression Vector for the Production of Single-Chain Fv Alkaline Phosphatase Fusion Proteins
Griep, Remko A., van Twisk, Charlotte, Kerschbaumer, Randolf J., Harper, Karen, Torrance, Lesley, Himmler, Gottfried, van der Wolf, Jan M., Schots, Arjen
Published in Protein expression and purification (01.06.1999)
Published in Protein expression and purification (01.06.1999)
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Journal Article