Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase
Aldred, Katie J., Blower, Tim R., Kerns, Robert J., Berger, James M., Osheroff, Neil
Published in Proceedings of the National Academy of Sciences - PNAS (16.02.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (16.02.2016)
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Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance
Aldred, Katie J, McPherson, Sylvia A, Turnbough, Jr, Charles L, Kerns, Robert J, Osheroff, Neil
Published in Nucleic acids research (01.04.2013)
Published in Nucleic acids research (01.04.2013)
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Overcoming Target-Mediated Quinolone Resistance in Topoisomerase IV by Introducing Metal-Ion-Independent Drug–Enzyme Interactions
Aldred, Katie J, Schwanz, Heidi A, Li, Gangqin, McPherson, Sylvia A, Turnbough, Charles L, Kerns, Robert J, Osheroff, Neil
Published in ACS chemical biology (20.12.2013)
Published in ACS chemical biology (20.12.2013)
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Bioenergetic effects of mitochondrial-targeted coenzyme Q analogs in endothelial cells
Fink, Brian D, Herlein, Judith A, Yorek, Mark A, Fenner, Amanda M, Kerns, Robert J, Sivitz, William I
Published in The Journal of pharmacology and experimental therapeutics (01.09.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2012)
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Fluoroquinolone and Quinazolinedione Activities against Wild-Type and Gyrase Mutant Strains of Mycobacterium smegmatis
MALIK, Muhammad, MARKS, Kevin R, MUSTAEV, Arkady, XILIN ZHAO, CHAVDA, Kalyan, KERNS, Robert J, DRLICA, Karl
Published in Antimicrobial Agents and Chemotherapy (01.05.2011)
Published in Antimicrobial Agents and Chemotherapy (01.05.2011)
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Novel Approach for Comparing the Abilities of Quinolones To Restrict the Emergence of Resistant Mutants during Quinolone Exposure
MALIK, Muhammad, HOATAM, Gerard, CHAVDA, Kalyan, KERNS, Robert J, DRLICA, Karl
Published in Antimicrobial Agents and Chemotherapy (01.01.2010)
Published in Antimicrobial Agents and Chemotherapy (01.01.2010)
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Effect of mitoquinone on liver metabolism and steatosis in obese and diabetic rats
Fink, Brian D., Yu, Liping, Coppey, Lawrence, Obrosov, Alexander, Shevalye, Hanna, Kerns, Robert J., Yorek, Mark A., Sivitz, William I.
Published in Pharmacology research & perspectives (01.02.2021)
Published in Pharmacology research & perspectives (01.02.2021)
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Quinolone-Mediated Bacterial Death
DRIICA, Karl, MALIK, Muhammad, KERNS, Robert J, XILIN ZHAO
Published in Antimicrobial agents and chemotherapy (01.02.2008)
Published in Antimicrobial agents and chemotherapy (01.02.2008)
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A Novel Triphenylphosphonium Carrier to Target Mitochondria without Uncoupling Oxidative Phosphorylation
Kulkarni, Chaitanya A, Fink, Brian D, Gibbs, Bettine E, Chheda, Pratik R, Wu, Meng, Sivitz, William I, Kerns, Robert J
Published in Journal of medicinal chemistry (14.01.2021)
Published in Journal of medicinal chemistry (14.01.2021)
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Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding
Mustaev, Arkady, Malik, Muhammad, Zhao, Xilin, Kurepina, Natalia, Luan, Gan, Oppegard, Lisa M, Hiasa, Hiroshi, Marks, Kevin R, Kerns, Robert J, Berger, James M, Drlica, Karl
Published in The Journal of biological chemistry (02.05.2014)
Published in The Journal of biological chemistry (02.05.2014)
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Promising antimalarials targeting apicoplast DNA polymerase from Plasmodium falciparum
Chheda, Pratik R., Nieto, Nicholas, Kaur, Supreet, Beck, John M., Beck, Josh R., Honzatko, Richard, Kerns, Robert J., Nelson, Scott W.
Published in European journal of medicinal chemistry (05.12.2022)
Published in European journal of medicinal chemistry (05.12.2022)
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