A new class of synthetic retinoid antibiotics effective against bacterial persisters
Kim, Wooseong, Zhu, Wenpeng, Hendricks, Gabriel Lambert, Van Tyne, Daria, Steele, Andrew D., Keohane, Colleen E., Fricke, Nico, Conery, Annie L., Shen, Steven, Pan, Wen, Lee, Kiho, Rajamuthiah, Rajmohan, Fuchs, Beth Burgwyn, Vlahovska, Petia M., Wuest, William M., Gilmore, Michael S., Gao, Huajian, Ausubel, Frederick M., Mylonakis, Eleftherios
Published in Nature (London) (05.04.2018)
Published in Nature (London) (05.04.2018)
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Promysalin Elicits Species-Selective Inhibition of Pseudomonas aeruginosa by Targeting Succinate Dehydrogenase
Keohane, Colleen E, Steele, Andrew D, Fetzer, Christian, Khowsathit, Jittasak, Van Tyne, Daria, Moynié, Lucile, Gilmore, Michael S, Karanicolas, John, Sieber, Stephan A, Wuest, William M
Published in Journal of the American Chemical Society (07.02.2018)
Published in Journal of the American Chemical Society (07.02.2018)
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Biological Evaluation of the Antibacterial Retinoid CD437 in Cutibacterium acnes Infection
Huang, Xiao-Wen, Pan, Wen, Zhong, Mei-Zhen, Chhonker, Yashpal Singh, Steele, Andrew D, Keohane, Colleen E, Mishra, Biswajit, Felix Raj Lucas, Lewis Oscar, Murry, Daryl J, Ausubel, Frederick M, Wuest, William M, Li, Chang-Xing, Mylonakis, Eleftherios
Published in Antimicrobial agents and chemotherapy (18.04.2023)
Published in Antimicrobial agents and chemotherapy (18.04.2023)
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Journal Article
Total Synthesis and Biological Investigation of (−)-Promysalin
Steele, Andrew D, Knouse, Kyle W, Keohane, Colleen E, Wuest, William M
Published in Journal of the American Chemical Society (17.06.2015)
Published in Journal of the American Chemical Society (17.06.2015)
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Diverted Total Synthesis of Promysalin Analogs Demonstrates That an Iron-Binding Motif Is Responsible for Its Narrow-Spectrum Antibacterial Activity
Steele, Andrew D, Keohane, Colleen E, Knouse, Kyle W, Rossiter, Sean E, Williams, Sierra J, Wuest, William M
Published in Journal of the American Chemical Society (11.05.2016)
Published in Journal of the American Chemical Society (11.05.2016)
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Correction to “Target-Based Design of Promysalin Analogs Identifies a New Putative Binding Cleft in Succinate Dehydrogenase”
Post, Savannah J., Keohane, Colleen E., Rossiter, Lauren M., Kaplan, Anna R., Khowsathit, Jittasak, Matuska, Katie, Karanicolas, John, Wuest, William M.
Published in ACS infectious diseases (08.07.2022)
Published in ACS infectious diseases (08.07.2022)
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Target-Based Design of Promysalin Analogues Identifies a New Putative Binding Cleft in Succinate Dehydrogenase
Post, Savannah J, Keohane, Colleen E, Rossiter, Lauren M, Kaplan, Anna R, Khowsathit, Jittasak, Matuska, Katie, Karanicolas, John, Wuest, William M
Published in ACS infectious diseases (12.06.2020)
Published in ACS infectious diseases (12.06.2020)
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Transcriptomic Profiling Suggests That Promysalin Alters the Metabolic Flux, Motility, and Iron Regulation in Pseudomonas putida KT2440
Giglio, Krista M, Keohane, Colleen E, Stodghill, Paul V, Steele, Andrew D, Fetzer, Christian, Sieber, Stephan A, Filiatrault, Melanie J, Wuest, William M
Published in ACS infectious diseases (10.08.2018)
Published in ACS infectious diseases (10.08.2018)
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N‑Heterocyclic 3‑Pyridyl Carboxamide Inhibitors of DHODH for the Treatment of Acute Myelogenous Leukemia
Cisar, Justin S., Pietsch, Christine, DeRatt, Lindsey G., Jacoby, Edgar, Kazmi, Faraz, Keohane, Colleen, Legenski, Katie, Matico, Rosalie, Shaffer, Paul, Simonnet, Yvan, Tanner, Alexandra, Wang, Chao-Yuan, Wang, Weixue, Attar, Ricardo, Edwards, James P., Kuduk, Scott D.
Published in Journal of medicinal chemistry (25.08.2022)
Published in Journal of medicinal chemistry (25.08.2022)
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ChemInform Abstract: Total Synthesis and Biological Investigation of (-)-Promysalin
Steele, Andrew D., Knouse, Kyle W., Keohane, Colleen E., Wuest, William M.
Published in ChemInform (01.12.2015)
Published in ChemInform (01.12.2015)
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Year of Publication 24.09.2021
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Year of Publication 24.09.2021
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Year of Publication 27.12.2023
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Year of Publication 27.12.2023
Patent
DIHYDROOROTATE DEHYDROGENASE INHIBITORS
Simonnet, Yvan Rene Ferdinand, Cisar, Justin, Keohane, Colleen Elizabeth, Kuduk, Scott, Jacoby, Edgar, Wang, Chao-yuan
Year of Publication 24.03.2022
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Year of Publication 24.03.2022
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Year of Publication 17.11.2021
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Year of Publication 17.11.2021
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