A Non–D2-Receptor-Binding Drug for the Treatment of Schizophrenia
Koblan, Kenneth S, Kent, Justine, Hopkins, Seth C, Krystal, John H, Cheng, Hailong, Goldman, Robert, Loebel, Antony
Published in The New England journal of medicine (16.04.2020)
Published in The New England journal of medicine (16.04.2020)
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Effect of TAAR1/5-HT1A agonist SEP-363856 on REM sleep in humans
Hopkins, Seth C., Dedic, Nina, Koblan, Kenneth S.
Published in Translational psychiatry (20.04.2021)
Published in Translational psychiatry (20.04.2021)
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TAAR1 agonists improve glycemic control, reduce body weight and modulate neurocircuits governing energy balance and feeding
Dedic, Nina, Wang, Lien, Hajos-Korcsok, Eva, Hecksher-Sørensen, Jacob, Roostalu, Urmas, Vickers, Steven P., Wu, Serena, Anacker, Christoph, Synan, Colleen, Jones, Philip G., Milanovic, Snezana, Hopkins, Seth C., Bristow, Linda J., Koblan, Kenneth S.
Published in Molecular metabolism (Germany) (01.02.2024)
Published in Molecular metabolism (Germany) (01.02.2024)
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Comparative Bioequivalence of Tablet and Capsule Formulations of Ulotaront and the Effect of Food on the Pharmacokinetics of the Tablet Form in Humans
Chen, Yu-Luan, Tsukada, Hironobu, Milanovic, Snezana, Shi, Lei, Li, Yan, Mao, Yongcai, Koblan, Kenneth S., Galluppi, Gerald R.
Published in Neurology and therapy (01.06.2023)
Published in Neurology and therapy (01.06.2023)
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Pharmacological Characterization of MK-0974 [N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of Migraine
Salvatore, Christopher A, Hershey, James C, Corcoran, Halea A, Fay, John F, Johnston, Victor K, Moore, Eric L, Mosser, Scott D, Burgey, Christopher S, Paone, Daniel V, Shaw, Anthony W, Graham, Samuel L, Vacca, Joseph P, Williams, Theresa M, Koblan, Kenneth S, Kane, Stefanie A
Published in The Journal of pharmacology and experimental therapeutics (01.02.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2008)
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Potent, Orally Bioavailable Calcitonin Gene-Related Peptide Receptor Antagonists for the Treatment of Migraine: Discovery of N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974)
Paone, Daniel V, Shaw, Anthony W, Nguyen, Diem N, Burgey, Christopher S, Deng, James Z, Kane, Stefanie A, Koblan, Kenneth S, Salvatore, Christopher A, Mosser, Scott D, Johnston, Victor K, Wong, Bradley K, Miller-Stein, Cynthia M, Hershey, James C, Graham, Samuel L, Vacca, Joseph P, Williams, Theresa M
Published in Journal of medicinal chemistry (15.11.2007)
Published in Journal of medicinal chemistry (15.11.2007)
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Effects of ulotaront on brain circuits of reward, working memory, and emotion processing in healthy volunteers with high or low schizotypy
Perini, Francesca, Nazimek, Jadwiga Maria, Mckie, Shane, Capitão, Liliana P., Scaife, Jessica, Pal, Deepa, Browning, Michael, Dawson, Gerard R., Nishikawa, Hiroyuki, Campbell, Una, Hopkins, Seth C., Loebel, Antony, Elliott, Rebecca, Harmer, Catherine J., Deakin, Bill, Koblan, Kenneth S.
Published in NPJ schizophrenia (07.08.2023)
Published in NPJ schizophrenia (07.08.2023)
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Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure
Winrow, Christopher J., Tanis, Keith Q., Reiss, Duane R., Rigby, Alison M., Uslaner, Jason M., Uebele, Victor N., Doran, Scott M., Fox, Steven V., Garson, Susan L., Gotter, Anthony L., Levine, David M., Roecker, Anthony J., Coleman, Paul J., Koblan, Kenneth S., Renger, John J.
Published in Neuropharmacology (2010)
Published in Neuropharmacology (2010)
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Challenges in the clinical development of non-D2 compounds for schizophrenia
Hopkins, Seth C., Lew, Robert, Zeni, Courtney, Koblan, Kenneth S.
Published in Current medical research and opinion (04.03.2023)
Published in Current medical research and opinion (04.03.2023)
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Receptor Activity-modifying Protein 1 Determines the Species Selectivity of Non-peptide CGRP Receptor Antagonists
Mallee, John J, Salvatore, Christopher A, LeBourdelles, Beatrice, Oliver, Kevin R, Longmore, Jenny, Koblan, Kenneth S, Kane, Stefanie A
Published in The Journal of biological chemistry (19.04.2002)
Published in The Journal of biological chemistry (19.04.2002)
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SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D2 Receptor Mechanism of Action
Dedic, Nina, Jones, Philip G, Hopkins, Seth C, Lew, Robert, Shao, Liming, Campbell, John E, Spear, Kerry L, Large, Thomas H, Campbell, Una C, Hanania, Taleen, Leahy, Emer, Koblan, Kenneth S
Published in The Journal of pharmacology and experimental therapeutics (01.10.2019)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2019)
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LRRTM3 Promotes Processing of Amyloid-Precursor Protein by BACE1 and Is a Positional Candidate Gene for Late-Onset Alzheimer's Disease
Majercak, John, Ray, William J., Espeseth, Amy, Simon, Adam, Shi, Xiao-Ping, Wolffe, Carrie, Getty, Krista, Marine, Shane, Stec, Erica, Ferrer, Marc, Strulovici, Berta, Bartz, Steven, Gates, Adam, Xu, Min, Huang, Qian, Ma, Lei, Shughrue, Paul, Burchard, Julja, Colussi, Dennis, Pietrak, Beth, Kahana, Jason, Beher, Dirk, Rosahl, Thomas, Shearman, Mark, Hazuda, Daria, Sachs, Alan B., Koblan, Kenneth S., Seabrook, Guy R., Stone, David J.
Published in Proceedings of the National Academy of Sciences - PNAS (21.11.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (21.11.2006)
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SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D 2 Receptor Mechanism of Action
Dedic, Nina, Jones, Philip G, Hopkins, Seth C, Lew, Robert, Shao, Liming, Campbell, John E, Spear, Kerry L, Large, Thomas H, Campbell, Una C, Hanania, Taleen, Leahy, Emer, Koblan, Kenneth S
Published in The Journal of pharmacology and experimental therapeutics (01.10.2019)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2019)
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Discovery of a Potent, CNS‐Penetrant Orexin Receptor Antagonist Based on an N,N‐Disubstituted‐1,4‐diazepane Scaffold that Promotes Sleep in Rats
Whitman, David B., Cox, Christopher D., Breslin, Michael J., Brashear, Karen M., Schreier, John D., Bogusky, Michael J., Bednar, Rodney A., Lemaire, Wei, Bruno, Joseph G., Hartman, George D., Reiss , Duane R., Harrell, C. Meacham, Kraus, Richard L., Li, Yuxing, Garson, Susan L., Doran, Scott M., Prueksaritanont, Thomayant, Li, Chunze, Winrow, Christopher J., Koblan, Kenneth S., Renger, John J., Coleman, Paul J.
Published in ChemMedChem (06.07.2009)
Published in ChemMedChem (06.07.2009)
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A Randomized, Double-blind, Placebo-controlled Proof-of-Concept Trial to Evaluate the Efficacy and Safety of Non-racemic Amisulpride (SEP-4199) for the Treatment of Bipolar I Depression
Loebel, Antony, Koblan, Kenneth S., Tsai, Joyce, Deng, Ling, Fava, Maurizio, Kent, Justine, Hopkins, Seth C.
Published in Journal of affective disorders (01.01.2022)
Published in Journal of affective disorders (01.01.2022)
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Discovery of Nonracemic Amisulpride to Maximize Benefit/Risk of 5‐HT7 and D2 Receptor Antagonism for the Treatment of Mood Disorders
Hopkins, Seth C., Wilkinson, Scott, Corriveau, Taryn J., Nishikawa, Hiroyuki, Nakamichi, Keiko, Loebel, Antony, Koblan, Kenneth S.
Published in Clinical pharmacology and therapeutics (01.09.2021)
Published in Clinical pharmacology and therapeutics (01.09.2021)
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TAAR1 and 5-HT1B receptor agonists attenuate autism-like irritability and aggression in rats prenatally exposed to valproic acid
Wang, Lien, Clark, Erin A., Hanratty, Lynsey, Koblan, Kenneth S., Foley, Andrew, Dedic, Nina, Bristow, Linda J.
Published in Pharmacology, biochemistry and behavior (01.12.2024)
Published in Pharmacology, biochemistry and behavior (01.12.2024)
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Functional and pharmacological properties of canine ERG potassium channels
Wang, Jixin, Della Penna, Kimberly, Wang, Hao, Karczewski, Jerzy, Connolly, Thomas M, Koblan, Kenneth S, Bennett, Paul B, Salata, Joseph J
Published in American journal of physiology. Heart and circulatory physiology (01.01.2003)
Published in American journal of physiology. Heart and circulatory physiology (01.01.2003)
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In Vitro ADME and Preclinical Pharmacokinetics of Ulotaront, a TAAR1/5-HT1A Receptor Agonist for the Treatment of Schizophrenia
Xiao, Guangqing, Chen, Yu-Luan, Dedic, Nina, Xie, Linghong, Koblan, Kenneth S., Galluppi, Gerald R.
Published in Pharmaceutical research (01.05.2022)
Published in Pharmaceutical research (01.05.2022)
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