Caprolactams as potent CGRP receptor antagonists for the treatment of migraine
Shaw, Anthony W., Paone, Daniel V., Nguyen, Diem N., Stump, Craig A., Burgey, Christopher S., Mosser, Scott D., Salvatore, Christopher A., Rutledge, Ruth Z., Kane, Stefanie A., Koblan, Kenneth S., Graham, Samuel L., Vacca, Joeseph P., Williams, Theresa M.
Published in Bioorganic & medicinal chemistry letters (01.09.2007)
Published in Bioorganic & medicinal chemistry letters (01.09.2007)
Get full text
Journal Article
3-Aminopyrrolidinone Farnesyltransferase Inhibitors: Design of Macrocyclic Compounds with Improved Pharmacokinetics and Excellent Cell Potency
Bell, Ian M, Gallicchio, Steven N, Abrams, Marc, Beese, Lorena S, Beshore, Douglas C, Bhimnathwala, Hema, Bogusky, Michael J, Buser, Carolyn A, Culberson, J. Christopher, Davide, Joseph, Ellis-Hutchings, Michelle, Fernandes, Christine, Gibbs, Jackson B, Graham, Samuel L, Hamilton, Kelly A, Hartman, George D, Heimbrook, David C, Homnick, Carl F, Huber, Hans E, Huff, Joel R, Kassahun, Kelem, Koblan, Kenneth S, Kohl, Nancy E, Lobell, Robert B, Lynch, Joseph J, Robinson, Ronald, Rodrigues, A. David, Taylor, Jeffrey S, Walsh, Eileen S, Williams, Theresa M, Zartman, C. Blair
Published in Journal of medicinal chemistry (06.06.2002)
Published in Journal of medicinal chemistry (06.06.2002)
Get full text
Journal Article
Calcitonin gene-related peptide (CGRP) receptor antagonists: Investigations of a pyridinone template
Nguyen, Diem N., Paone, Daniel V., Shaw, Anthony W., Burgey, Christopher S., Mosser, Scott D., Johnston, Victor, Salvatore, Christopher A., Leonard, Yvonne M., Miller-Stein, Cynthia M., Kane, Stefanie A., Koblan, Kenneth S., Vacca, Joseph P., Graham, Samuel L., Williams, Theresa M.
Published in Bioorganic & medicinal chemistry (15.01.2008)
Published in Bioorganic & medicinal chemistry (15.01.2008)
Get full text
Journal Article
NR2B-Selective N-Methyl-d-aspartate Antagonists: Synthesis and Evaluation of 5-Substituted Benzimidazoles
McCauley, John A., Theberge, Cory R., Romano, Joseph J., Billings, Susan B., Anderson, Kenneth D., Claremon, David A., Freidinger, Roger M., Bednar, Rodney A., Mosser, Scott D., Gaul, Stanley L., Connolly, Thomas M., Condra, Cindra L., Xia, Menghang, Cunningham, Michael E., Bednar, Bohumil, Stump, Gary L., Lynch, Joseph J., Macaulay, Alison, Wafford, Keith A., Koblan, Kenneth S., Liverton, Nigel J.
Published in Journal of medicinal chemistry (08.04.2004)
Published in Journal of medicinal chemistry (08.04.2004)
Get full text
Journal Article
Estimating heterogeneity of treatment effect in psychiatric clinical trials
Siegel, Joshua S, Zhong, Jinglin, Tomioka, Sasagu, Ogirala, Ajay, Faraone, Stephen V, Szabo, Steven T, Koblan, Kenneth S, Hopkins, Seth C
Published in medRxiv : the preprint server for health sciences (23.04.2024)
Published in medRxiv : the preprint server for health sciences (23.04.2024)
Get more information
Journal Article
Proline bis-amides as potent dual orexin receptor antagonists
Bergman, Jeffrey M., Roecker, Anthony J., Mercer, Swati P., Bednar, Rodney A., Reiss, Duane R., Ransom, Richard W., Meacham Harrell, C., Pettibone, Douglas J., Lemaire, Wei, Murphy, Kathy L., Li, Chunze, Prueksaritanont, Thomayant, Winrow, Christopher J., Renger, John J., Koblan, Kenneth S., Hartman, George D., Coleman, Paul J.
Published in Bioorganic & medicinal chemistry (15.02.2008)
Published in Bioorganic & medicinal chemistry (15.02.2008)
Get full text
Journal Article
A Farnesyltransferase Inhibitor Induces Tumor Regression in Transgenic Mice Harboring Multiple Oncogenic Mutations by Mediating Alterations in Both Cell Cycle Control and Apoptosis
Barrington, Rebecca E., Subler, Mark A., Rands, Elaine, Omer, Charles A., Miller, Patricia J., Hundley, Jeffrey E., Koester, Steven K., Troyer, Dean A., Bearss, David J., Conner, Michael W., Gibbs, Jackson B., Hamilton, Kelly, Koblan, Kenneth S., Mosser, Scott D., O'Neill, Timothy J., Schaber, Michael D., Senderak, Edith T., Windle, Jolene J., Oliff, Allen, Kohl, Nancy E.
Published in Molecular and Cellular Biology (01.01.1998)
Published in Molecular and Cellular Biology (01.01.1998)
Get full text
Journal Article
Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl :protein transferase inhibitor
OMER, C. A, ZUNXUAN CHEN, DAVIDE, J. P, ELLIS, M. S, GIBBS, J. B, GREENBERG, I, HAMILTON, K, KOBLAN, K. S, KRAL, A. M, DONGMING LIU, LOBELL, R. B, MILLER, P. J, DIEHL, R. E, MOSSER, S. D, O'NEILL, T. J, RANDS, E, SCHABER, M. D, SENDERAK, E. T, OLIFF, A, KOHL, N. E, CONNER, M. W, CHEN, H. Y, TRUMBAUER, M. E, GOPAL-TRUTER, S, SEEBURGER, G, BHIMNATHWALA, H, ABRAMS, M. T
Published in Cancer research (Chicago, Ill.) (15.05.2000)
Get full text
Published in Cancer research (Chicago, Ill.) (15.05.2000)
Journal Article
T-type calcium channels regulate cortical plasticity in-vivo. [corrected]
Uebele, Victor N, Nuss, Cindy E, Santarelli, Vincent P, Garson, Susan L, Kraus, Richard L, Barrow, James C, Stauffer, Shaun R, Koblan, Kenneth S, Renger, John J, Aton, Sara, Seibt, Julie, Dumoulin, Michelle, Jha, Sushil K, Coleman, Tammi, Frank, Marcos G
Published in Neuroreport (18.02.2009)
Published in Neuroreport (18.02.2009)
Get more information
Journal Article
Conformational Restriction of Flexible Ligands Guided by the Transferred NOE Experiment: Potent Macrocyclic Inhibitors of Farnesyltransferase
Dinsmore, Christopher J, Bogusky, Michael J, Culberson, J. Christopher, Bergman, Jeffrey M, Homnick, Carl F, Zartman, C. Blair, Mosser, Scott D, Schaber, Michael D, Robinson, Ronald G, Koblan, Kenneth S, Huber, Hans E, Graham, Samuel L, Hartman, George D, Huff, Joel R, Williams, Theresa M
Published in Journal of the American Chemical Society (07.03.2001)
Published in Journal of the American Chemical Society (07.03.2001)
Get full text
Journal Article
Characterisation of the effects of a non-peptide CGRP receptor antagonist in SK-N-MC cells and isolated human cerebral arteries
Edvinsson, Lars, Sams, Anette, Jansen-Olesen, Inger, Tajti, Janos, Kane, Stefanie A, Rutledge, Ruth Z, Koblan, Kenneth S, Hill, Raymond G, Longmore, Jenny
Published in European journal of pharmacology (09.03.2001)
Published in European journal of pharmacology (09.03.2001)
Get full text
Journal Article
Imidazole-containing diarylether and diarylsulfone inhibitors of farnesyl-protein transferase
Dinsmore, Christopher J., Williams, Theresa M., O'Neill, Timothy J., Liu, Dongming, Rands, Elaine, Culberson, J.Christopher, Lobell, Robert B., Koblan, Kenneth S., Kohl, Nancy E., Gibbs, Jackson B., Oliff, Allen I., Graham, Samuel L., Hartman, George D.
Published in Bioorganic & medicinal chemistry letters (06.12.1999)
Published in Bioorganic & medicinal chemistry letters (06.12.1999)
Get full text
Journal Article
Design, Synthesis, and Evaluation of a Novel 4-Aminomethyl-4-fluoropiperidine as a T-Type Ca2+ Channel Antagonist
Shipe, William D, Barrow, James C, Yang, Zhi-Qiang, Lindsley, Craig W, Yang, F. Vivien, Schlegel, Kelly-Ann S, Shu, Youheng, Rittle, Kenneth E, Bock, Mark G, Hartman, George D, Tang, Cuyue, Ballard, Jeanine E, Kuo, Yuhsin, Adarayan, Emily D, Prueksaritanont, Thomayant, Zrada, Matthew M, Uebele, Victor N, Nuss, Cindy E, Connolly, Thomas M, Doran, Scott M, Fox, Steven V, Kraus, Richard L, Marino, Michael J, Graufelds, Valerie Kuzmick, Vargas, Hugo M, Bunting, Patricia B, Hasbun-Manning, Martha, Evans, Rose M, Koblan, Kenneth S, Renger, John J
Published in Journal of medicinal chemistry (10.07.2008)
Published in Journal of medicinal chemistry (10.07.2008)
Get full text
Journal Article
In Vitro ADME and Preclinical Pharmacokinetics of Ulotaront, a TAAR1/5-HT.sub.1A Receptor Agonist for the Treatment of Schizophrenia
Xiao, Guangqing, Chen, Yu-Luan, Dedic, Nina, Xie, Linghong, Koblan, Kenneth S, Galluppi, Gerald R
Published in Pharmaceutical research (01.05.2022)
Published in Pharmaceutical research (01.05.2022)
Get full text
Journal Article
In vitro characterization of novel NR2B selective NMDA receptor antagonists
Kiss, Laszlo, Cheng, Gong, Bednar, Bohumil, Bednar, Rodney A., Bennett, Paul B., Kane, Stefanie A., McIntyre, Charles J., McCauley, John A., Koblan, Kenneth S.
Published in Neurochemistry international (01.05.2005)
Published in Neurochemistry international (01.05.2005)
Get full text
Journal Article
Farnesyltransferase inhibitors versus Ras inhibitors
Gibbs, Jackson B, Graham, Samuel L, Hartman, George D, Koblan, Kenneth S, Kohl, Nancy E, Omer, Charles A, Oliff, Allen
Published in Current opinion in chemical biology (01.08.1997)
Published in Current opinion in chemical biology (01.08.1997)
Get full text
Journal Article
Kinetic characterization of novel NR2B antagonists using fluorescence detection of calcium flux
Bednar, Bohumil, Cunningham, Michael E, Kiss, Laszlo, Cheng, Gong, McCauley, John A, Liverton, Nigel J, Koblan, Kenneth S
Published in Journal of neuroscience methods (30.08.2004)
Published in Journal of neuroscience methods (30.08.2004)
Get full text
Journal Article