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HER2 and HLA-A02 dual CAR-T cells utilize LOH in a NOT logic gate to address on-target off-tumor toxicity
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Paracrine Expression of a Native Soluble Vascular Endothelial Growth Factor Receptor Inhibits Tumor Growth, Metastasis, and Mortality Rate
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Kinetic Mechanism of AKT/PKB Enzyme Family
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Preclinical Evaluation of AMG 900, a Novel Potent and Highly Selective Pan-Aurora Kinase Inhibitor with Activity in Taxane-Resistant Tumor Cell Lines
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AMG 900, a small-molecule inhibitor of aurora kinases, potentiates the activity of microtubule-targeting agents in human metastatic breast cancer models
Bush, Tammy L, Payton, Marc, Heller, Scott, Chung, Grace, Hanestad, Kelly, Rottman, James B, Loberg, Robert, Friberg, Gregory, Kendall, Richard L, Saffran, Douglas, Radinsky, Robert
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Discovery of a Potent, Selective, and Orally Bioavailable Pyridinyl-Pyrimidine Phthalazine Aurora Kinase Inhibitor
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Published in Science (American Association for the Advancement of Science) (07.05.1999)
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Synthesis and Initial SAR Studies of 3,6-Disubstituted Pyrazolo[1,5- a]pyrimidines: A New Class of KDR Kinase Inhibitors
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Published in Bioorganic & medicinal chemistry letters (07.10.2002)
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Optimization of a pyrazolo[1,5- a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics
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Eukaryotic Methionyl Aminopeptidases: Two Classes of Cobalt-Dependent Enzymes
Arfin, Stuart M., Kendall, Richard L., Hall, Linda, Weaver, Larry H., Stewart, Albert E., Matthews, Brian W., Bradshaw, Ralph A.
Published in Proceedings of the National Academy of Sciences - PNAS (15.08.1995)
Published in Proceedings of the National Academy of Sciences - PNAS (15.08.1995)
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Vascular Endothelial Growth Factor Receptor KDR Tyrosine Kinase Activity Is Increased by Autophosphorylation of Two Activation Loop Tyrosine Residues
Kendall, R L, Rutledge, R Z, Mao, X, Tebben, A J, Hungate, R W, Thomas, K A
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The discovery of N-(1,3-thiazol-2-yl)pyridin-2-amines as potent inhibitors of KDR kinase
Bilodeau, Mark T., Rodman, Leonard D., McGaughey, Georgia B., Coll, Kathleen E., Koester, Timothy J., Hoffman, William F., Hungate, Randall W., Kendall, Richard L., McFall, Rosemary C., Rickert, Keith W., Rutledge, Ruth Z., Thomas, Kenneth A.
Published in Bioorganic & medicinal chemistry letters (07.06.2004)
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Design and synthesis of 1,5-diarylbenzimidazoles as inhibitors of the VEGF-receptor KDR
Bilodeau, Mark T., Cunningham, April M., Koester, Timothy J., Ciecko, Patrice A., Coll, Kathleen E., Huckle, William R., Hungate, Randall W., Kendall, Richard L., McFall, Rosemary C., Mao, Xianzhi, Rutledge, Ruth Z., Thomas, Kenneth A.
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Discovery and evaluation of 3-(5-thien-3-ylpyridin-3-yl)-1H-indoles as a novel class of KDR kinase inhibitors
Fraley, Mark E, Arrington, Kenneth L, Hambaugh, Scott R, Hoffman, William F, Cunningham, April M, Young, Mary Beth, Hungate, Randall W, Tebben, Andrew J, Rutledge, Ruth Z, Kendall, Richard L, Huckle, William R, McFall, Rosemary C, Coll, Kathleen E, Thomas, Kenneth A
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Abstract 5797: Next generation antibody drug conjugates: Multi-payload conjugates targeting multiple mechanisms of cell killing
Kendall, Richard L., Lobba, Marco, Johri, Saurabh, Symister, Chanez, Trinter, Devin, Nguyen, Maxwell, Gutierrez, Daniel, Brady, Samantha, Lau, Andrew, Francis, Matthew B.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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AMG 900, a Potent and Highly Selective Aurora Kinase Inhibitor Shows Promising Preclinical Activity Against Acute Myeloid Leukemia Cell Lines In Vitro and In Vivo
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Kendall, R.L., Wang, G., Disalvo, J., Thomas, K.A.
Published in Biochemical and biophysical research communications (30.05.1994)
Published in Biochemical and biophysical research communications (30.05.1994)
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