Neurotrophin Signaling via TrkB and TrkC Receptors Promotes the Growth of Brain Tumor-initiating Cells
Lawn, Samuel, Krishna, Niveditha, Pisklakova, Alexandra, Qu, Xiaotao, Fenstermacher, David A., Fournier, Michelle, Vrionis, Frank D., Tran, Nam, Chan, Jennifer A., Kenchappa, Rajappa S., Forsyth, Peter A.
Published in The Journal of biological chemistry (06.02.2015)
Published in The Journal of biological chemistry (06.02.2015)
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Enhancing Brain Retention of a KIF11 Inhibitor Significantly Improves its Efficacy in a Mouse Model of Glioblastoma
Gampa, Gautham, Kenchappa, Rajappa S, Mohammad, Afroz S, Parrish, Karen E, Kim, Minjee, Crish, James F, Luu, Amanda, West, Rita, Hinojosa, Alfredo Quinones, Sarkaria, Jann N, Rosenfeld, Steven S, Elmquist, William F
Published in Scientific reports (16.04.2020)
Published in Scientific reports (16.04.2020)
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M011L-deficient oncolytic myxoma virus induces apoptosis in brain tumor-initiating cells and enhances survival in a novel immunocompetent mouse model of glioblastoma
Pisklakova, Alexandra, McKenzie, Brienne, Zemp, Franz, Lun, Xueqing, Kenchappa, Rajappa S, Etame, Arnold B, Rahman, Masmudur M, Reilly, Karlyne, Pilon-Thomas, Shari, McFadden, Grant, Kurz, Ebba, Forsyth, Peter A
Published in Neuro-oncology (Charlottesville, Va.) (01.08.2016)
Published in Neuro-oncology (Charlottesville, Va.) (01.08.2016)
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The 1p36 Tumor Suppressor KIF 1Bβ Is Required for Calcineurin Activation, Controlling Mitochondrial Fission and Apoptosis
Li, Shuijie, Fell, Stuart M., Surova, Olga, Smedler, Erik, Wallis, Karin, Chen, Zhi Xiong, Hellman, Ulf, Johnsen, John Inge, Martinsson, Tommy, Kenchappa, Rajappa S., Uhlén, Per, Kogner, Per, Schlisio, Susanne
Published in Developmental cell (25.01.2016)
Published in Developmental cell (25.01.2016)
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Activation of the p75 Neurotrophin Receptor through Conformational Rearrangement of Disulphide-Linked Receptor Dimers
Vilar, Marçal, Charalampopoulos, Ioannis, Kenchappa, Rajappa S., Simi, Anastasia, Karaca, Esra, Reversi, Alessandra, Choi, Soyoung, Bothwell, Mark, Mingarro, Ismael, Friedman, Wilma J., Schiavo, Giampietro, Bastiaens, Philippe I.H., Verveer, Peter J., Carter, Bruce D., Ibáñez, Carlos F.
Published in Neuron (Cambridge, Mass.) (16.04.2009)
Published in Neuron (Cambridge, Mass.) (16.04.2009)
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Ligand-Dependent Cleavage of the P75 Neurotrophin Receptor Is Necessary for NRIF Nuclear Translocation and Apoptosis in Sympathetic Neurons
Kenchappa, Rajappa S., Zampieri, Niccolò, Chao, Moses V., Barker, Philip A., Teng, Henry K., Hempstead, Barbara L., Carter, Bruce D.
Published in Neuron (Cambridge, Mass.) (20.04.2006)
Published in Neuron (Cambridge, Mass.) (20.04.2006)
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Journal Article
Myosin 10 Regulates Invasion, Mitosis, and Metabolic Signaling in Glioblastoma
Kenchappa, Rajappa S., Mistriotis, Panagiotis, Wisniewski, Emily, Bhattacharya, Santanu, Kulkarni, Tanmay, West, Rita, Luu, Amanda, Conlon, Meghan, Heimsath, Ernest, Crish, James F., Picariello, Hannah S., Dovas, Athanassios, Zarco, Natanael, Lara-Velazquez, Montserrat, Quiñones-Hinojosa, Alfredo, Hammer, John A., Mukhopadhyay, Debrabrata, Cheney, Richard E., Konstantopoulos, Konstantinos, Canoll, Peter, Rosenfeld, Steven S.
Published in iScience (18.12.2020)
Published in iScience (18.12.2020)
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Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility
Astuti, Dewi, Ricketts, Christopher J, Chowdhury, Rasheduzzaman, McDonough, Michael A, Gentle, Dean, Kirby, Gail, Schlisio, Susanne, Kenchappa, Rajappa S, Carter, Bruce D, Kaelin, William G, Ratcliffe, Peter J, Schofield, Christopher J, Latif, Farida, Maher, Eamonn R
Published in Endocrine-related cancer (01.02.2011)
Published in Endocrine-related cancer (01.02.2011)
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Journal Article
Myosin IIA suppresses glioblastoma development in a mechanically sensitive manner
Picariello, Hannah S., Kenchappa, Rajappa S., Rai, Vandana, Crish, James F., Dovas, Athanassios, Pogoda, Katarzyna, McMahon, Mariah, Bell, Emily S., Chandrasekharan, Unnikrishnan, Luu, Amanda, West, Rita, Lammerding, Jan, Canoll, Peter, Odde, David J., Janmey, Paul A., Egelhoff, Thomas, Rosenfeld, Steven S.
Published in Proceedings of the National Academy of Sciences - PNAS (30.07.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (30.07.2019)
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Journal Article
p75 Neurotrophin Receptor-mediated Apoptosis in Sympathetic Neurons Involves a Biphasic Activation of JNK and Up-regulation of Tumor Necrosis Factor-α-converting Enzyme/ADAM17
Kenchappa, Rajappa S., Tep, Chhavy, Korade, Zeljka, Urra, Soledad, Bronfman, Francisca C., Yoon, Sung Ok, Carter, Bruce D.
Published in The Journal of biological chemistry (25.06.2010)
Published in The Journal of biological chemistry (25.06.2010)
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Journal Article
BIRC3 is a novel driver of therapeutic resistance in Glioblastoma
Wang, Dapeng, Berglund, Anders, Kenchappa, Rajappa S, Forsyth, Peter A, Mulé, James J, Etame, Arnold B
Published in Scientific reports (18.02.2016)
Published in Scientific reports (18.02.2016)
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Journal Article
The kinesin KIF1Bβ acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor
Schlisio, Susanne, Kenchappa, Rajappa S., Vredeveld, Liesbeth C.W., George, Rani E., Stewart, Rodney, Greulich, Heidi, Shahriari, Kristina, Nguyen, Nguyen V., Pigny, Pascal, Dahia, Patricia L., Pomeroy, Scott L., Maris, John M., Look, A. Thomas, Meyerson, Matthew, Peeper, Daniel S., Carter, Bruce D., Kaelin, William G.
Published in Genes & development (01.04.2008)
Published in Genes & development (01.04.2008)
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Journal Article
Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma
Kenchappa, Rajappa S., Dovas, Athanassios, Argenziano, Michael G., Meyer, Christian T., Stopfer, Lauren E., Banu, Matei A., Pereira, Brianna, Griffith, Jessica, Mohammad, Afroz, Talele, Surabhi, Haddock, Ashley, Zarco, Natanael, Elmquist, William, White, Forest, Quaranta, Vito, Sims, Peter, Canoll, Peter, Rosenfeld, Steven S.
Published in Cell reports (Cambridge) (21.06.2022)
Published in Cell reports (Cambridge) (21.06.2022)
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Journal Article
BIRC3 is a biomarker of mesenchymal habitat of glioblastoma, and a mediator of survival adaptation in hypoxia-driven glioblastoma habitats
Wang, Dapeng, Berglund, Anders E, Kenchappa, Rajappa S, MacAulay, Robert J, Mulé, James J, Etame, Arnold B
Published in Scientific reports (24.08.2017)
Published in Scientific reports (24.08.2017)
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Journal Article
p75 Neurotrophin Receptor Cleavage by α- and γ-Secretases Is Required for Neurotrophin-mediated Proliferation of Brain Tumor-initiating Cells
Forsyth, Peter A., Krishna, Niveditha, Lawn, Samuel, Valadez, J. Gerardo, Qu, Xiaotao, Fenstermacher, David A., Fournier, Michelle, Potthast, Lisa, Chinnaiyan, Prakash, Gibney, Geoffrey T., Zeinieh, Michele, Barker, Philip A., Carter, Bruce D., Cooper, Michael K., Kenchappa, Rajappa S.
Published in The Journal of biological chemistry (21.03.2014)
Published in The Journal of biological chemistry (21.03.2014)
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Journal Article
Protein kinase Cι and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities
Kenchappa, Rajappa S., Liu, Yi, Argenziano, Michael G., Banu, Matei A., Mladek, Ann C., West, Rita, Luu, Amanda, Quiñones-Hinojosa, Alfredo, Hambardzumyan, Dolores, Justilien, Verline, Leitges, Michael, Sarkaria, Jann N., Sims, Peter A., Canoll, Peter, Murray, Nicole R., Fields, Alan P., Rosenfeld, Steven S.
Published in Cell reports (Cambridge) (23.11.2021)
Published in Cell reports (Cambridge) (23.11.2021)
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In vitro screen of a small molecule inhibitor drug library identifies multiple compounds that synergize with oncolytic myxoma virus against human brain tumor-initiating cells
McKenzie, Brienne A, Zemp, Franz J, Pisklakova, Alexandra, Narendran, Aru, McFadden, Grant, Lun, Xueqing, Kenchappa, Rajappa S, Kurz, Ebba U, Forsyth, Peter A
Published in Neuro-oncology (Charlottesville, Va.) (01.08.2015)
Published in Neuro-oncology (Charlottesville, Va.) (01.08.2015)
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Journal Article
Neuroblast differentiation during development and in neuroblastoma requires KIF1Bβ-mediated transport of TRKA
Fell, Stuart M, Li, Shuijie, Wallis, Karin, Kock, Anna, Surova, Olga, Rraklli, Vilma, Höfig, Carolin S, Li, Wenyu, Mittag, Jens, Henriksson, Marie Arsenian, Kenchappa, Rajappa S, Holmberg, Johan, Kogner, Per, Schlisio, Susanne
Published in Genes & development (15.05.2017)
Published in Genes & development (15.05.2017)
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