Mechanism of proton transfer in class A β-lactamase catalysis and inhibition by avibactam
Pemberton, Orville A., Noor, Radwan E., M.V., Vasantha Kumar, Sanishvili, Ruslan, Kemp, M. Trent, Kearns, Fiona L., Woodcock, H. Lee, Gelis, Ioannis, Chen, Yu
Published in Proceedings of the National Academy of Sciences - PNAS (17.03.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (17.03.2020)
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Journal Article
Staphylococcus aureus FtsZ and PBP4 bind to the conformationally dynamic N-terminal domain of GpsB
Sacco, Michael D, Hammond, Lauren R, Noor, Radwan E, Bhattacharya, Dipanwita, McKnight, Lily J, Madsen, Jesper J, Zhang, Xiujun, Butler, Shane G, Kemp, M Trent, Jaskolka-Brown, Aiden C, Khan, Sebastian J, Gelis, Ioannis, Eswara, Prahathees, Chen, Yu
Published in eLife (19.04.2024)
Published in eLife (19.04.2024)
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Influence of the α-Methoxy Group on the Reaction of Temocillin with Pseudomonas aeruginosa PBP3 and CTX-M-14 β-Lactamase
Sacco, Michael D, Kroeck, Kyle G, Kemp, M Trent, Zhang, Xiujun, Andrews, Logan D, Chen, Yu
Published in Antimicrobial agents and chemotherapy (20.12.2019)
Published in Antimicrobial agents and chemotherapy (20.12.2019)
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Journal Article
Low barrier hydrogen bonds in protein structure and function
Kemp, M. Trent, Lewandowski, Eric M., Chen, Yu
Published in Biochimica et biophysica acta. Proteins and proteomics (01.01.2021)
Published in Biochimica et biophysica acta. Proteins and proteomics (01.01.2021)
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Journal Article
Modeling Boronic Acid Based Fluorescent Saccharide Sensors: Computational Investigation of d‑Fructose Binding to Dimethylaminomethylphenylboronic Acid
Kearns, Fiona L, Robart, Carrie, Kemp, M. Trent, Vankayala, Sai Lakshmana, Chapin, Brette M, Anslyn, Eric V, Woodcock, H. Lee, Larkin, Joseph D
Published in Journal of chemical information and modeling (28.05.2019)
Published in Journal of chemical information and modeling (28.05.2019)
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Structure-Based Identification of Novel Ligands Targeting Multiple Sites within a Chemokine–G-Protein-Coupled-Receptor Interface
Smith, Emmanuel W, Nevins, Amanda M, Qiao, Zhen, Liu, Yan, Getschman, Anthony E, Vankayala, Sai L, Kemp, M. Trent, Peterson, Francis C, Li, Rongshi, Volkman, Brian F, Chen, Yu
Published in Journal of medicinal chemistry (12.05.2016)
Published in Journal of medicinal chemistry (12.05.2016)
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An empirical study of amide-heteroarene pi-stacking interactions using reversible inhibitors of a bacterial serine hydrolase
DeFrees, Kyle, Kemp, M. Trent, ElHilali-Pollard, Xochina, Zhang, Xiujun, Mohamed, Ahmed, Chen, Yu, Renslo, Adam R.
Published in ORGANIC CHEMISTRY FRONTIERS (07.06.2019)
Published in ORGANIC CHEMISTRY FRONTIERS (07.06.2019)
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Synthesis, characterization, and cellular localization of a fluorescent probe of the antimalarial 8-aminoquinoline primaquine
McQueen, Adonis, Blake, Lynn D., Azhari, Ala, Kemp, M. Trent, McGaha, Tommy W., Namelikonda, Niranjan, Larsen, Randy W., Manetsch, Roman, Kyle, Dennis E.
Published in Bioorganic & medicinal chemistry letters (15.10.2017)
Published in Bioorganic & medicinal chemistry letters (15.10.2017)
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Journal Article
The role of a conserved Asp-Asp pair in the structure, function, and inhibition of CTX-M Class A β-lactamase
Kemp, M. Trent, Nichols, Derek A, Zhang, Xiujun, Defrees, Kyle, Na, Insung, Renslo, Adam R., Chen, Yu
Published in FEBS letters (07.11.2021)
Published in FEBS letters (07.11.2021)
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Photoacoustic calorimetry study of ligand photorelease from the Ru(II)bis(2,2′-bipyridine)(6,6′-dimethyl-2,2′-bipyridine) complex in aqueous solution
Word, Tarah A., Whittington, Christi L., Karolak, Aleksandra, Kemp, M. Trent, Woodcock, H. Lee, van der Vaart, Arjan, Larsen, Randy W.
Published in Chemical physics letters (05.01.2015)
Published in Chemical physics letters (05.01.2015)
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Journal Article
Ru(II)Bis(2,2′ Bipyridine)L Complexes as Photorelease Agents for Bioactive Molecules: Photothermal Studies of Ligand Release
Larsen, Randy W., Karolak, Aleksandra, Word, Tarah A., Kemp, M. Trent, Whittington, Christi L., Woodcock, H. Lee, van der Vaart, Arjan
Published in Biophysical journal (28.01.2014)
Published in Biophysical journal (28.01.2014)
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The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition
Sacco, Michael D, Hu, Yanmei, Gongora, Maura V, Meilleur, Flora, Kemp, M Trent, Zhang, Xiujun, Wang, Jun, Chen, Yu
Published in bioRxiv (27.01.2022)
Published in bioRxiv (27.01.2022)
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Paper
Staphylococcus aureus FtsZ and PBP4 bind to the conformationally dynamic N-terminal domain of GpsB
Sacco, Michael D, Hammond, Lauren R, Noor, Radwan E, Bhattacharya, Dipanwita, Madsen, Jesper J, Zhang, Xiujun, Butler, Shane G, Kemp, M Trent, Jaskolka-Brown, Aiden C, Khan, Sebastian J, Gelis, Ioannis, Eswara, Prahathees J, Chen, Yu
Published in bioRxiv (25.10.2022)
Published in bioRxiv (25.10.2022)
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